Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3587-3595

  Wang, Zhengqiang ^a   Vince, Robert ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Dual inhibitors; HIV; Integrase; Reverse transcriptase

Indexed keywords

1 [2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 5 YL]ETHANONE; 1 [2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 7 YL]ETHANONE; 1 [3 BROMO 2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 5 YL]ETHANONE; 1 [3 BROMO 2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 7 YL]ETHANONE; 1 [3 CHLORO 2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 5 YL]ETHANONE; 1 [3 CHLORO 2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 7 YL]ETHANONE; 4 [2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 5 YL] 2 HYDROXY 4 OXOBUT 2 ENOIC ACID; 5 ACYL 1H INDOLE 2 CARBOXYLIC ACID; 5 ACYL 3 BROMO 1H INDOLE 2 CARBOXYLIC ACID; 5 ACYL 3 CHLORO 1H INDOLE 2 CARBOXYLIC ACID; 7 ACYL 1H INDOLE 2 CARBOXYLIC ACID; 7 ACYL 3 BROMO 1H INDOLE 2 CARBOXYLIC ACID; 7 ACYL 3 CHLORO 1H INDOLE 2 CARBOXYLIC ACID; DELAVIRDINE; DIKETOACID; ETHYL 2 [2 (4 ACETYLPHENYL)HYDRAZONO]PROPANOATE; ETHYL 3 BROMO 1H INDOLE 2 CARBOXYLATE; ETHYL 3 CHLORO 1H INDOLE 2 CARBOXYLATE; ETHYL 4 [3 BROMO 2 [4 [3 (ISOPROPYLAMINO)PYRIDIN 2 YL]PIPERAZINE 1 CARBONYL] 1H INDOL 5 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 5 ACYL 1H INDOLE 2 CARBOXYLATE; ETHYL 5 ACYL 3 BROMO 1H INDOLE 2 CARBOXYLATE; ETHYL 5 ACYL 3 CHLORO 1H INDOLE 2 CARBOXYLATE; ETHYL 7 ACYL 3 1H INDOLE 2 CARBOXYLATE; ETHYL 7 ACYL 3 BROMO 1H INDOLE 2 CARBOXYLATE; ETHYL 7 ACYL 3 CHLORO 1H INDOLE 2 CARBOXYLATE; INTEGRASE INHIBITOR; OXOACID; RNA DIRECTED DNA POLYMERASE INHIBITOR; TNK 651; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DRUG SYNTHESIS; ENZYMATIC ASSAY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN;

DELAVIRDINE; DRUG DESIGN; HIV; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; KETO ACIDS; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 41649107669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.007     Document Type: Article

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