Improving the solubility and bioavailability of dihydroartemisinin by solid dispersions and inclusion complexes

Archives of Pharmacal Research

Volumn 34, Issue 5, 2011, Pages 757-765

  Ansari, Muhammad Tayyab ^a   Batty, Kevin T ^b   Iqbal, Ijaz ^a   Sunderland, Vivian Bruce ^b  

^a BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^b CURTIN UNIVERSITY   (Australia)

Author keywords

Bioavailability; Dihydroartemisinin; Hydroxypropyl cyclodextrin; Pharmacokinetics; Polyvinylpyrrolidone; Solubility

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; DIHYDROARTEMISININ; POLYMER; POVIDONE; WATER;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SOLUBILITY; ENTHALPY; IN VIVO STUDY; MELTING POINT; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHASE TRANSITION; SOLID DISPERSION; THERMOGRAPHY; X RAY DIFFRACTION;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG COMPOUNDING; HALF-LIFE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METABOLIC CLEARANCE RATE; MICE; MOLECULAR WEIGHT; PHASE TRANSITION; POVIDONE; RANDOM ALLOCATION; SOLUBILITY; SUSPENSIONS; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 79960239502     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0509-1     Document Type: Article

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