N-3 hydroxylation of pyrimidine-2,4-diones yields dual inhibitors of HIV reverse transcriptase and integrase

ACS Medicinal Chemistry Letters

Volumn 2, Issue 1, 2011, Pages 63-67

  Tang, Jing ^a   Maddali, Kasthuraiah ^b   Dreis, Christine D ^a   Sham, Yuk Y ^a   Vince, Robert ^a   Pommier, Yves ^b   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

dual inhibitor; HIV; integrase; rational design; reverse transcriptase

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 1 [5 (4 FLUOROBENZYL) 2 FURYL] 3 (1,2,4 TRIAZOL 3 YL) 1,3 PROPANEDIONE; ELVITEGRAVIR; EMIVIRINE; INTEGRASE; INTEGRASE INHIBITOR; N (4 FLUOROBENZYL) 8 HYDROXY 5 (TETRAHYDRO 2H 1,2 THIAZIN 2 YL) 1,6 NAPHTHYRIDINE 7 CARBOXAMIDE S,S DIOXIDE; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TNK 651; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG STRUCTURE; HUMAN; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 78651481692     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1002162     Document Type: Article

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