Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

Drug Metabolism and Disposition

Volumn 30, Issue 9, 2002, Pages 1005-1012

  Ilett, Kenneth F ^a   Ethell, Brian T ^b   Maggs, James L ^a   Davis, Timothy M E ^c   Batty, Kevin T ^d   Burchell, Brian ^e   Binh, Tran Quang ^f   Thu, Le Thi Anh ^g   Hung, Nguyen Canh ^h   Pirmohamed, Munir ^a   Kevin Park, B ^b   Edwards, Geoffrey ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Western Australian Centre for Pathology and Medical Research   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e CHO RAY HOSPITAL   (Viet Nam)

^f Bao Loc Hospital   (Viet Nam)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

^h LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DIHYDROARTEMISININ BETA GLUCURONIDE; ARTESUNATE; CAPTOPRIL; CEFOXITIN; CIMETIDINE; CYTOCHROME P450; DEXAMETHASONE; DIHYDROARTEMISININ; DOBUTAMINE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; HYDROCORTISONE; IPRATROPIUM BROMIDE; PARACETAMOL; PHENYTOIN; RANITIDINE; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DIHYDROQUINGHAOSU; RECOMBINANT PROTEIN; SESQUITERPENE;

ADULT; ARTICLE; CATALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CYTOSOL; LIVER MICROSOME; MALARIA FALCIPARUM; MALE; MASS SPECTROMETRY; METABOLIC REGULATION; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOCHEMISTRY; SULFATION; URINALYSIS; VIET NAM; IN VITRO STUDY; METABOLISM; URINE;

ADULT; ANTIMALARIALS; ARTEMISININS; FEMALE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMAN; IN VITRO; MALARIA, FALCIPARUM; MALE; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SESQUITERPENES; SUPPORT, NON-U.S. GOV'T; HUMANS;

ARTESUNATE;

EID: 0036707622     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.9.1005     Document Type: Article

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