메뉴 건너뛰기




Volumn 84, Issue 6, 2012, Pages 737-745

Insulin resistance in the brain: An old-age or new-age problem?

Author keywords

Dementia; Diabetes; Insulin resistance

Indexed keywords

INSULIN; INSULIN RECEPTOR; METFORMIN; SOMATOMEDIN C;

EID: 84864921644     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.05.007     Document Type: Note
Times cited : (61)

References (100)
  • 1
    • 0036973393 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging
    • C. MacKnight, K. Rockwood, E. Awalt, and I. McDowell Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging Dement Geriatr Cogn Disord 14 2002 77 83
    • (2002) Dement Geriatr Cogn Disord , vol.14 , pp. 77-83
    • MacKnight, C.1    Rockwood, K.2    Awalt, E.3    McDowell, I.4
  • 3
    • 28444491100 scopus 로고    scopus 로고
    • Cognitive decline and dementia in diabetes - Systematic overview of prospective observational studies
    • T. Cukierman, H.C. Gerstein, and J.D. Williamson Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies Diabetologia 48 2005 2460 2469
    • (2005) Diabetologia , vol.48 , pp. 2460-2469
    • Cukierman, T.1    Gerstein, H.C.2    Williamson, J.D.3
  • 6
    • 20544462061 scopus 로고    scopus 로고
    • Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study
    • R.A. Whitmer, E.P. Gunderson, E. Barrett-Connor, C.P.J. Quesenberry, and K. Yaffe Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study BMJ 330 2005 1360
    • (2005) BMJ , vol.330 , pp. 1360
    • Whitmer, R.A.1    Gunderson, E.P.2    Barrett-Connor, E.3    Quesenberry, C.P.J.4    Yaffe, K.5
  • 7
    • 80555157642 scopus 로고    scopus 로고
    • Glucose tolerance status and risk of dementia in the community: The Hisayama Study
    • T. Ohara, Y. Doi, T. Ninomiya, Y. Hirakawa, J. Hata, and T. Iwaki Glucose tolerance status and risk of dementia in the community: the Hisayama Study Neurology 77 2011 1126 1134
    • (2011) Neurology , vol.77 , pp. 1126-1134
    • Ohara, T.1    Doi, Y.2    Ninomiya, T.3    Hirakawa, Y.4    Hata, J.5    Iwaki, T.6
  • 8
  • 9
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • G.I. Shulman Cellular mechanisms of insulin resistance J Clin Invest 106 2000 171 176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 11
    • 0030000582 scopus 로고    scopus 로고
    • Insulin sensitivity and endothelial function: A physiological relationship with implications for pathophysiology of cardiovascular disease
    • J.R. Petrie, S. Ueda, D.J. Webb, H.L. Elliott, and J.M.C. Connell Insulin sensitivity and endothelial function: a physiological relationship with implications for pathophysiology of cardiovascular disease Circulation 93 1996 1331 1333
    • (1996) Circulation , vol.93 , pp. 1331-1333
    • Petrie, J.R.1    Ueda, S.2    Webb, D.J.3    Elliott, H.L.4    Connell, J.M.C.5
  • 12
    • 62149138077 scopus 로고    scopus 로고
    • Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo
    • M. Rajkhowa, S. Brett, D.J. Cuthbertson, C. Lipina, A.J. Ruiz-Alcaraz, and G.E. Thomas Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo Biochem J 418 2009 665 671
    • (2009) Biochem J , vol.418 , pp. 665-671
    • Rajkhowa, M.1    Brett, S.2    Cuthbertson, D.J.3    Lipina, C.4    Ruiz-Alcaraz, A.J.5    Thomas, G.E.6
  • 13
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • M.F. White IRS proteins and the common path to diabetes Am J Physiol Endocrinol Metab 283 2002 E413 E422
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1
  • 14
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • K. Morino, K.F. Petersen, S. Dufour, D. Befroy, J. Frattini, and N. Shatzkes Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents J Clin Invest 115 2005 3587 3593
    • (2005) J Clin Invest , vol.115 , pp. 3587-3593
    • Morino, K.1    Petersen, K.F.2    Dufour, S.3    Befroy, D.4    Frattini, J.5    Shatzkes, N.6
  • 15
    • 0034455274 scopus 로고    scopus 로고
    • The insulin signaling system - A common link in the pathogenesis of type 2 diabetes
    • D.J. Withers, and White M. Perspective The insulin signaling system - a common link in the pathogenesis of type 2 diabetes Endocrinology 141 2000 1917 1921
    • (2000) Endocrinology , vol.141 , pp. 1917-1921
    • Withers, D.J.1    Perspective, W.M.2
  • 18
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by PKB
    • G. Rena, S. Guo, S.C. Cichy, T.G. Unterman, and P. Cohen Phosphorylation of the transcription factor forkhead family member FKHR by PKB J Biol Chem 274 1999 17179 17183
    • (1999) J Biol Chem , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 19
    • 0035038729 scopus 로고    scopus 로고
    • Inhibition of GSK3 selectively reduces G6Pase and PEPCK gene expression
    • P.A. Lochhead, M.P. Coghlan, S.Q.J. Rice, and C. Sutherland Inhibition of GSK3 selectively reduces G6Pase and PEPCK gene expression Diabetes 50 2001 937 947
    • (2001) Diabetes , vol.50 , pp. 937-947
    • Lochhead, P.A.1    Coghlan, M.P.2    Rice, S.Q.J.3    Sutherland, C.4
  • 21
    • 0037677096 scopus 로고    scopus 로고
    • Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
    • H. Sano, S. Kane, E. Sano, C.P. Miinea, J.M. Asara, and W.S. Lane Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation J Biol Chem 278 2003 14599 14602
    • (2003) J Biol Chem , vol.278 , pp. 14599-14602
    • Sano, H.1    Kane, S.2    Sano, E.3    Miinea, C.P.4    Asara, J.M.5    Lane, W.S.6
  • 23
    • 0030664286 scopus 로고    scopus 로고
    • Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin
    • W.A. Banks, J.B. Jaspan, W. Huang, and A.J. Kastin Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin Peptides 18 1997 1423 1429
    • (1997) Peptides , vol.18 , pp. 1423-1429
    • Banks, W.A.1    Jaspan, J.B.2    Huang, W.3    Kastin, A.J.4
  • 24
    • 0031426348 scopus 로고    scopus 로고
    • Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin
    • W.A. Banks, J.B. Jaspan, and A.J. Kastin Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin Peptides 18 1997 1577 1584
    • (1997) Peptides , vol.18 , pp. 1577-1584
    • Banks, W.A.1    Jaspan, J.B.2    Kastin, A.J.3
  • 25
    • 33845468713 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer disease: Pathophysiologic mechanisms and therapeutic implications
    • S. Craft Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications Alzheimer Dis Assoc Disord 20 2006 298 301
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , pp. 298-301
    • Craft, S.1
  • 27
    • 0026049397 scopus 로고
    • Development of glutamate neurotoxicity in cortical cultures: Induction of vulnerability by insulin
    • M. Schafer, and S.L. Erdo Development of glutamate neurotoxicity in cortical cultures: induction of vulnerability by insulin Brain Res Dev Brain Res 62 1991 293 296
    • (1991) Brain Res Dev Brain Res , vol.62 , pp. 293-296
    • Schafer, M.1    Erdo, S.L.2
  • 28
    • 0033521130 scopus 로고    scopus 로고
    • Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
    • W. Zhao, H. Chen, H. Xu, E. Moore, N. Meiri, and M.J. Quon Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats J Biol Chem 274 1999 34893 34902
    • (1999) J Biol Chem , vol.274 , pp. 34893-34902
    • Zhao, W.1    Chen, H.2    Xu, H.3    Moore, E.4    Meiri, N.5    Quon, M.J.6
  • 29
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • J.W. Unger, J.N. Livingston, and A.M. Moss Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects Prog Neurobiol 36 1991 343 362
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 30
    • 84858145166 scopus 로고    scopus 로고
    • Insulin promotes neuronal survival via the alternatively spliced protein kinase CdeltaII isoform
    • A. Apostolatos, S. Song, S. Acosta, M. Peart, J.E. Watson, and P. Bickford Insulin promotes neuronal survival via the alternatively spliced protein kinase CdeltaII isoform J Biol Chem 287 2012 9299 9310
    • (2012) J Biol Chem , vol.287 , pp. 9299-9310
    • Apostolatos, A.1    Song, S.2    Acosta, S.3    Peart, M.4    Watson, J.E.5    Bickford, P.6
  • 31
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype
    • M.A. Reger, G.S. Watson, W.H. Frey 2nd, L.D. Baker, B. Cholerton, and M.L. Keeling Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype Neurobiol Aging 27 2006 451 458
    • (2006) Neurobiol Aging , vol.27 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey II, W.H.3    Baker, L.D.4    Cholerton, B.5    Keeling, M.L.6
  • 33
    • 0038177803 scopus 로고    scopus 로고
    • Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: Interactions with apolipoprotein e genotype
    • S. Craft, S. Asthana, D.G. Cook, L.D. Baker, M. Cherrier, and K. Purganan Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype Psychoneuroendocrinology 28 2003 809 822
    • (2003) Psychoneuroendocrinology , vol.28 , pp. 809-822
    • Craft, S.1    Asthana, S.2    Cook, D.G.3    Baker, L.D.4    Cherrier, M.5    Purganan, K.6
  • 35
    • 0037452760 scopus 로고    scopus 로고
    • Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    • A. Convit, O.T. Wolf, C. Tarshish, and M.J. de Leon Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly Proc Natl Acad Sci U S A 100 2003 2019 2022
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2019-2022
    • Convit, A.1    Wolf, O.T.2    Tarshish, C.3    De Leon, M.J.4
  • 37
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease pathogenesis: Potential mechanisms and implications for treatment
    • S. Craft Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment Curr Alzheimer Res 4 2007 147 152
    • (2007) Curr Alzheimer Res , vol.4 , pp. 147-152
    • Craft, S.1
  • 38
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
    • E.J. Rivera, A. Goldin, N. Fulmer, R. Tavares, J.R. Wands, and S.M. de la Monte Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine J Alzheimers Dis 8 2005 247 268
    • (2005) J Alzheimers Dis , vol.8 , pp. 247-268
    • Rivera, E.J.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.R.5    De La Monte, S.M.6
  • 39
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - Is this type 3 diabetes
    • E. Steen, B.M. Terry, E.J. Rivera, J.L. Cannon, T.R. Neely, and R. Tavares Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes J Alzheimers Dis 7 2005 63 80
    • (2005) J Alzheimers Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3    Cannon, J.L.4    Neely, T.R.5    Tavares, R.6
  • 40
    • 0036895563 scopus 로고    scopus 로고
    • The role of insulin in human brain glucose metabolism: An 18fluoro-deoxyglucose positron emission tomography study
    • E.M. Bingham, D. Hopkins, D. Smith, A. Pernet, W. Hallett, and L. Reed The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study Diabetes 51 2002 3384 3390
    • (2002) Diabetes , vol.51 , pp. 3384-3390
    • Bingham, E.M.1    Hopkins, D.2    Smith, D.3    Pernet, A.4    Hallett, W.5    Reed, L.6
  • 41
    • 0027321678 scopus 로고
    • Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system
    • A.M. Brant, T.J. Jess, G. Milligan, C.M. Brown, and G.W. Gould Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system Biochem Biophys Res Commun 192 1993 1297 1302
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 1297-1302
    • Brant, A.M.1    Jess, T.J.2    Milligan, G.3    Brown, C.M.4    Gould, G.W.5
  • 43
    • 0032863618 scopus 로고    scopus 로고
    • Effects of posttraining administration of insulin on retention of a habituation response in mice: Participation of a central cholinergic mechanism
    • S.R. Kopf, and C.M. Baratti Effects of posttraining administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism Neurobiol Learn Mem 71 1999 50 61
    • (1999) Neurobiol Learn Mem , vol.71 , pp. 50-61
    • Kopf, S.R.1    Baratti, C.M.2
  • 44
    • 0027400795 scopus 로고
    • Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus
    • D.P. Figlewicz, P. Szot, P.A. Israel, C. Payne, and D.M. Dorsa Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus Brain Res 602 1993 161 164
    • (1993) Brain Res , vol.602 , pp. 161-164
    • Figlewicz, D.P.1    Szot, P.2    Israel, P.A.3    Payne, C.4    Dorsa, D.M.5
  • 45
    • 0035853124 scopus 로고    scopus 로고
    • Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis
    • V.A. Skeberdis, J. Lan, X. Zheng, R.S. Zukin, and M.V. Bennett Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis Proc Natl Acad Sci U S A 98 2001 3561 3566
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3561-3566
    • Skeberdis, V.A.1    Lan, J.2    Zheng, X.3    Zukin, R.S.4    Bennett, M.V.5
  • 46
  • 48
    • 17844391064 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
    • S.J. Fisher, J.C. Bruning, S. Lannon, and C.R. Kahn Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia Diabetes 54 2005 1447 1451
    • (2005) Diabetes , vol.54 , pp. 1447-1451
    • Fisher, S.J.1    Bruning, J.C.2    Lannon, S.3    Kahn, C.R.4
  • 49
    • 77956367937 scopus 로고    scopus 로고
    • Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia
    • K.A. Diggs-Andrews, X. Zhang, Z. Song, D. Daphna-Iken, V.H. Routh, and S.J. Fisher Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia Diabetes 59 2010 2271 2280
    • (2010) Diabetes , vol.59 , pp. 2271-2280
    • Diggs-Andrews, K.A.1    Zhang, X.2    Song, Z.3    Daphna-Iken, D.4    Routh, V.H.5    Fisher, S.J.6
  • 50
    • 79955394878 scopus 로고    scopus 로고
    • Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors
    • M. Sanchez-Alavez, O. Osborn, I.V. Tabarean, K.H. Holmberg, J. Eberwine, and C.R. Kahn Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors J Biol Chem 286 2011 14983 14990
    • (2011) J Biol Chem , vol.286 , pp. 14983-14990
    • Sanchez-Alavez, M.1    Osborn, O.2    Tabarean, I.V.3    Holmberg, K.H.4    Eberwine, J.5    Kahn, C.R.6
  • 53
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • S. Obici, Z. Feng, G. Karkanias, D.G. Baskin, and L. Rossetti Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats Nat Neurosci 5 2002 566 572
    • (2002) Nat Neurosci , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 54
    • 80055011903 scopus 로고    scopus 로고
    • Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain
    • S.A. Paranjape, O. Chan, W. Zhu, A.M. Horblitt, C.A. Grillo, and S. Wilson Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain Am J Physiol Endocrinol Metab 301 2011 E978 E983
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Paranjape, S.A.1    Chan, O.2    Zhu, W.3    Horblitt, A.M.4    Grillo, C.A.5    Wilson, S.6
  • 56
    • 79959652223 scopus 로고    scopus 로고
    • High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
    • T. Klockener, S. Hess, B.F. Belgardt, L. Paeger, L.A. Verhagen, and A. Husch High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons Nat Neurosci 14 2011 911 918
    • (2011) Nat Neurosci , vol.14 , pp. 911-918
    • Klockener, T.1    Hess, S.2    Belgardt, B.F.3    Paeger, L.4    Verhagen, L.A.5    Husch, A.6
  • 57
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • A.C. Konner, R. Janoschek, L. Plum, S.D. Jordan, E. Rother, and X. Ma Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production Cell Metab 5 2007 438 449
    • (2007) Cell Metab , vol.5 , pp. 438-449
    • Konner, A.C.1    Janoschek, R.2    Plum, L.3    Jordan, S.D.4    Rother, E.5    Ma, X.6
  • 58
    • 79958026765 scopus 로고    scopus 로고
    • Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis
    • A.C. Konner, S. Hess, S. Tovar, A. Mesaros, C. Sanchez-Lasheras, and N. Evers Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis Cell Metab 13 2011 720 728
    • (2011) Cell Metab , vol.13 , pp. 720-728
    • Konner, A.C.1    Hess, S.2    Tovar, S.3    Mesaros, A.4    Sanchez-Lasheras, C.5    Evers, N.6
  • 59
    • 4644286910 scopus 로고    scopus 로고
    • Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    • L. Ho, W. Qin, P.N. Pompl, Z. Xiang, J.X. Wang, and Z. Zhao Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease FASEB J 18 2004 902 908
    • (2004) FASEB J , vol.18 , pp. 902-908
    • Ho, L.1    Qin, W.2    Pompl, P.N.3    Xiang, Z.4    Wang, J.X.5    Zhao, Z.6
  • 60
    • 77954955083 scopus 로고    scopus 로고
    • High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
    • C. Julien, C. Tremblay, A. Phivilay, L. Berthiaume, V. Emond, and P. Julien High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model Neurobiol Aging 31 2010 1516 1531
    • (2010) Neurobiol Aging , vol.31 , pp. 1516-1531
    • Julien, C.1    Tremblay, C.2    Phivilay, A.3    Berthiaume, L.4    Emond, V.5    Julien, P.6
  • 61
    • 77951028451 scopus 로고    scopus 로고
    • Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
    • S. Takeda, N. Sato, K. Uchio-Yamada, K. Sawada, T. Kunieda, and D. Takeuchi Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes Proc Natl Acad Sci U S A 107 2010 7036 7041
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7036-7041
    • Takeda, S.1    Sato, N.2    Uchio-Yamada, K.3    Sawada, K.4    Kunieda, T.5    Takeuchi, D.6
  • 62
    • 84864931749 scopus 로고    scopus 로고
    • Insulin receptor signaling mediates APP processing and beta-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
    • [Epub ahead of print]
    • O. Stohr, K. Schilbach, L. Moll, M.M. Hettich, S. Freude, and F.T. Wunderlich Insulin receptor signaling mediates APP processing and beta-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease Age (Dordrecht) 2011 [Epub ahead of print]
    • (2011) Age (Dordrecht)
    • Stohr, O.1    Schilbach, K.2    Moll, L.3    Hettich, M.M.4    Freude, S.5    Wunderlich, F.T.6
  • 63
    • 70349672704 scopus 로고    scopus 로고
    • Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
    • S. Freude, M.M. Hettich, C. Schumann, O. Stohr, L. Koch, and C. Kohler Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease FASEB J 23 2009 3315 3324
    • (2009) FASEB J , vol.23 , pp. 3315-3324
    • Freude, S.1    Hettich, M.M.2    Schumann, C.3    Stohr, O.4    Koch, L.5    Kohler, C.6
  • 64
    • 78149325368 scopus 로고    scopus 로고
    • High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task
    • A.D. McNeilly, R. Williamson, C. Sutherland, D.J. Balfour, and C.A. Stewart High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task Behav Brain Res 217 2011 134 141
    • (2011) Behav Brain Res , vol.217 , pp. 134-141
    • McNeilly, A.D.1    Williamson, R.2    Sutherland, C.3    Balfour, D.J.4    Stewart, C.A.5
  • 65
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • A. Belfiore, F. Frasca, G. Pandini, L. Sciacca, and R. Vigneri Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease Endocr Rev 30 2009 586 623
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 66
    • 84856113332 scopus 로고    scopus 로고
    • A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
    • A. Fafalios, J. Ma, X. Tan, J. Stoops, J. Luo, and M.C. Defrances A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism Nat Med 17 2011 1577 1584
    • (2011) Nat Med , vol.17 , pp. 1577-1584
    • Fafalios, A.1    Ma, J.2    Tan, X.3    Stoops, J.4    Luo, J.5    Defrances, M.C.6
  • 67
    • 70350335299 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor i and cognitive function: Neuromodulation throughout the lifespan
    • A. Aleman, and I. Torres-Aleman Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespan Prog Neurobiol 89 2009 256 265
    • (2009) Prog Neurobiol , vol.89 , pp. 256-265
    • Aleman, A.1    Torres-Aleman, I.2
  • 68
    • 33745269576 scopus 로고    scopus 로고
    • Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice
    • J. Svensson, M. Diez, J. Engel, C. Wass, A. Tivesten, and J.O. Jansson Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice J Endocrinol 189 2006 617 627
    • (2006) J Endocrinol , vol.189 , pp. 617-627
    • Svensson, J.1    Diez, M.2    Engel, J.3    Wass, C.4    Tivesten, A.5    Jansson, J.O.6
  • 69
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • Y. Liu, F. Liu, I. Grundke-Iqbal, K. Iqbal, and C.X. Gong Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes J Pathol 225 2011 54 62
    • (2011) J Pathol , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 70
    • 34548453703 scopus 로고    scopus 로고
    • Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells
    • L. Logie, A.J. Ruiz-Alcaraz, M. Keane, Y.L. Woods, J. Bain, and R. Marquez Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells Diabetes 56 2007 2218 2227
    • (2007) Diabetes , vol.56 , pp. 2218-2227
    • Logie, L.1    Ruiz-Alcaraz, A.J.2    Keane, M.3    Woods, Y.L.4    Bain, J.5    Marquez, R.6
  • 71
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • M. Townsend, T. Mehta, and D.J. Selkoe Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway J Biol Chem 282 2007 33305 33312
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 72
    • 60549084867 scopus 로고    scopus 로고
    • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
    • F.G. De Felice, M.N. Vieira, T.R. Bomfim, H. Decker, P.T. Velasco, and M.P. Lambert Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers Proc Natl Acad Sci U S A 106 2009 1971 1976
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1971-1976
    • De Felice, F.G.1    Vieira, M.N.2    Bomfim, T.R.3    Decker, H.4    Velasco, P.T.5    Lambert, M.P.6
  • 73
    • 0342424195 scopus 로고    scopus 로고
    • In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis
    • B. Diaz, J. Serna, F. De Pablo, and E.J. de la Rosa In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis Development 127 2000 1641 1649
    • (2000) Development , vol.127 , pp. 1641-1649
    • Diaz, B.1    Serna, J.2    De Pablo, F.3    De La Rosa, E.J.4
  • 75
    • 0000398342 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
    • W.Q. Qiu, D.M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, and M.B. Podlisny Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation J Biol Chem 273 1998 32730 32738
    • (1998) J Biol Chem , vol.273 , pp. 32730-32738
    • Qiu, W.Q.1    Walsh, D.M.2    Ye, Z.3    Vekrellis, K.4    Zhang, J.5    Podlisny, M.B.6
  • 76
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    • W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, and M.P. Frosch Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proc Natl Acad Sci U S A 100 2003 4162 4167
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3    Lindsley, L.4    Eckman, E.A.5    Frosch, M.P.6
  • 77
    • 70949100259 scopus 로고    scopus 로고
    • Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease
    • D.P. Hanger, A. Seereeram, and W. Noble Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease Expert Rev Neurother 9 2009 1647 1666
    • (2009) Expert Rev Neurother , vol.9 , pp. 1647-1666
    • Hanger, D.P.1    Seereeram, A.2    Noble, W.3
  • 78
    • 77958597709 scopus 로고    scopus 로고
    • Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain
    • M.P. Soutar, W.Y. Kim, R. Williamson, M. Peggie, C.J. Hastie, and H. McLauchlan Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain J Neurochem 115 2010 974 983
    • (2010) J Neurochem , vol.115 , pp. 974-983
    • Soutar, M.P.1    Kim, W.Y.2    Williamson, R.3    Peggie, M.4    Hastie, C.J.5    McLauchlan, H.6
  • 80
    • 33747083535 scopus 로고    scopus 로고
    • Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics
    • A.M. Abbatecola, M.R. Rizzo, M. Barbieri, R. Grella, A. Arciello, and M.T. Laieta Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics Neurology 67 2006 235 240
    • (2006) Neurology , vol.67 , pp. 235-240
    • Abbatecola, A.M.1    Rizzo, M.R.2    Barbieri, M.3    Grella, R.4    Arciello, A.5    Laieta, M.T.6
  • 81
    • 0031025854 scopus 로고    scopus 로고
    • Is type II diabetes associated with an increased risk of cognitive dysfunction. A critical review of published studies
    • M.W. Strachan, I.J. Deary, F.M. Ewing, and B.M. Frier Is type II diabetes associated with an increased risk of cognitive dysfunction. A critical review of published studies Diabetes Care 20 1997 438 445
    • (1997) Diabetes Care , vol.20 , pp. 438-445
    • Strachan, M.W.1    Deary, I.J.2    Ewing, F.M.3    Frier, B.M.4
  • 82
    • 4644233538 scopus 로고    scopus 로고
    • Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes
    • A.J. Sommerfield, I.J. Deary, and B.M. Frier Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes Diabetes Care 27 2004 2335 2340
    • (2004) Diabetes Care , vol.27 , pp. 2335-2340
    • Sommerfield, A.J.1    Deary, I.J.2    Frier, B.M.3
  • 83
    • 80054748660 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): A randomised open-label substudy
    • L.J. Launer, M.E. Miller, J.D. Williamson, R.M. Lazar, H.C. Gerstein, and A.M. Murray Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy Lancet Neurol 10 2011 969 977
    • (2011) Lancet Neurol , vol.10 , pp. 969-977
    • Launer, L.J.1    Miller, M.E.2    Williamson, J.D.3    Lazar, R.M.4    Gerstein, H.C.5    Murray, A.M.6
  • 84
    • 79960880118 scopus 로고    scopus 로고
    • Assessing the contribution of inflammation in models of Alzheimer's disease
    • H. Johnston, H. Boutin, and S.M. Allan Assessing the contribution of inflammation in models of Alzheimer's disease Biochem Soc Trans 39 2011 886 890
    • (2011) Biochem Soc Trans , vol.39 , pp. 886-890
    • Johnston, H.1    Boutin, H.2    Allan, S.M.3
  • 85
    • 34547380204 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder
    • J. Rogers, D. Mastroeni, B. Leonard, J. Joyce, and A. Grover Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder Int Rev Neurobiol 82 2007 235 246
    • (2007) Int Rev Neurobiol , vol.82 , pp. 235-246
    • Rogers, J.1    Mastroeni, D.2    Leonard, B.3    Joyce, J.4    Grover, A.5
  • 86
    • 77249153620 scopus 로고    scopus 로고
    • Cognitive impairment following high fat diet consumption is associated with brain inflammation
    • P.J. Pistell, C.D. Morrison, S. Gupta, A.G. Knight, J.N. Keller, and D.K. Ingram Cognitive impairment following high fat diet consumption is associated with brain inflammation J Neuroimmunol 219 2010 25 32
    • (2010) J Neuroimmunol , vol.219 , pp. 25-32
    • Pistell, P.J.1    Morrison, C.D.2    Gupta, S.3    Knight, A.G.4    Keller, J.N.5    Ingram, D.K.6
  • 87
    • 26444553356 scopus 로고    scopus 로고
    • Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    • M.A. Fishel, G.S. Watson, T.J. Montine, Q. Wang, P.S. Green, and J.J. Kulstad Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults Arch Neurol 62 2005 1539 1544
    • (2005) Arch Neurol , vol.62 , pp. 1539-1544
    • Fishel, M.A.1    Watson, G.S.2    Montine, T.J.3    Wang, Q.4    Green, P.S.5    Kulstad, J.J.6
  • 88
    • 64249121164 scopus 로고    scopus 로고
    • A look inside the diabetic brain: Contributors to diabetes-induced brain aging
    • S.A. Wrighten, G.G. Piroli, C.A. Grillo, and L.P. Reagan A look inside the diabetic brain: contributors to diabetes-induced brain aging Biochim Biophys Acta 1792 2009 444 453
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 444-453
    • Wrighten, S.A.1    Piroli, G.G.2    Grillo, C.A.3    Reagan, L.P.4
  • 89
    • 13744249406 scopus 로고    scopus 로고
    • PPARgamma-mediated insulin sensitization: The importance of fat versus muscle
    • U. Kintscher, and R.E. Law PPARgamma-mediated insulin sensitization: the importance of fat versus muscle Am J Physiol Endocrinol Metab 288 2005 E287 E291
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Kintscher, U.1    Law, R.E.2
  • 90
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • C.K. Combs, D.E. Johnson, J.C. Karlo, S.B. Cannady, and G.E. Landreth Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists J Neurosci 20 2000 558 567
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 91
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • P. Delerive, J.C. Fruchart, and B. Staels Peroxisome proliferator- activated receptors in inflammation control J Endocrinol 169 2001 453 459
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 92
    • 9644268167 scopus 로고    scopus 로고
    • Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease
    • W.A. Pedersen, and E.R. Flynn Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease Neurobiol Dis 17 2004 500 506
    • (2004) Neurobiol Dis , vol.17 , pp. 500-506
    • Pedersen, W.A.1    Flynn, E.R.2
  • 93
    • 33644592598 scopus 로고    scopus 로고
    • Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study
    • G.S. Watson, B.A. Cholerton, M.A. Reger, L.D. Baker, S.R. Plymate, and S. Asthana Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study Am J Geriatr Psychiatry 13 2005 950 958
    • (2005) Am J Geriatr Psychiatry , vol.13 , pp. 950-958
    • Watson, G.S.1    Cholerton, B.A.2    Reger, M.A.3    Baker, L.D.4    Plymate, S.R.5    Asthana, S.6
  • 94
    • 79959974461 scopus 로고    scopus 로고
    • Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: Two phase 3 studies
    • C. Harrington, S. Sawchak, C. Chiang, J. Davies, C. Donovan, and A.M. Saunders Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies Curr Alzheimer Res 8 2011 592 606
    • (2011) Curr Alzheimer Res , vol.8 , pp. 592-606
    • Harrington, C.1    Sawchak, S.2    Chiang, C.3    Davies, J.4    Donovan, C.5    Saunders, A.M.6
  • 95
  • 96
    • 62649115914 scopus 로고    scopus 로고
    • Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
    • Y. Chen, K. Zhou, R. Wang, Y. Liu, Y.D. Kwak, and T. Ma Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription Proc Natl Acad Sci U S A 106 2009 3907 3912
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3907-3912
    • Chen, Y.1    Zhou, K.2    Wang, R.3    Liu, Y.4    Kwak, Y.D.5    Ma, T.6
  • 97
    • 79956277464 scopus 로고    scopus 로고
    • Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    • C.C. Hsu, M.L. Wahlqvist, M.S. Lee, and H.N. Tsai Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin J Alzheimers Dis 24 2011 485 493
    • (2011) J Alzheimers Dis , vol.24 , pp. 485-493
    • Hsu, C.C.1    Wahlqvist, M.L.2    Lee, M.S.3    Tsai, H.N.4
  • 98
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • P.L. McClean, V. Parthsarathy, E. Faivre, and C. Holscher The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease J Neurosci 31 2011 6587 6594
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 99
    • 84859726053 scopus 로고    scopus 로고
    • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Abeta oligomers
    • T.R. Bomfim, L. Forny-Germano, L.B. Sathler, J. Brito-Moreira, J.C. Houzel, and H. Decker An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Abeta oligomers J Clin Invest 122 2012 1339 1353
    • (2012) J Clin Invest , vol.122 , pp. 1339-1353
    • Bomfim, T.R.1    Forny-Germano, L.2    Sathler, L.B.3    Brito-Moreira, J.4    Houzel, J.C.5    Decker, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.