Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression

Diabetes

Volumn 50, Issue 5, 2001, Pages 937-946

  Lochhead, Pamela A ^a   Coghlan, Matthew ^b   Rice, Simon Q J ^b   Sutherland, Calum ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; ENZYME INHIBITOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; LIVER; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035038729     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.937     Document Type: Article

References (68)

1. The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM
2. Molecular physiology and genetics of NIDDM: Importance of metabolic staging
3. A molecular basis for insulin resistance
4. The IRS-signalling system: A network of docking proteins that mediate insulin action
5. The role of PI 3-kinase in insulin action
6. PKB kinases that mediate PI 3,4,5-trisphosphate-dependent activation of PKB
7. Intracellular signalling: PDK1 - A kinase at the hub of things
8. Kinase phosphorylation: Keeping it all in the family
9. Inhibition of GSK-3 by insulin mediated by protein kinase B
10. Inactivation of glycogen synthase kinase-3β by phosphorylation: New kinase connections in insulin and growth factor signalling
11. The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro
12. Selective small molecule inhibitors of GSK-3 modulate glycogen metabolism and gene transcription
13. Regulation of gene transcription by insulin and the search for diabetogenes (Chapter 23)
14. Regulation of gene expression by insulin
15. PEPCK gene as a model of inhibitory effects of insulin on gene transcription
16. New connections in the regulation of PEPCK gene expression by insulin
17. Glucose-6-phosphatase structure, regulation, and function: An update
18. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone, and cAMP
19. Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin
20. Transgenic mice overexpressing PEPCK develop NIDDM
21. Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive PEPCK gene
22. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
23. Regulation of gene expression by insulin
24. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states
25. Regulation of PEPCK gene expression
26. Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase gene expression by insulin
27. Insulin regulation of PEPCK gene expression does not require activation of the Ras/MAP kinase signaling pathway
28. Activation of the Ras-MAP kinase-RSK pathway is not required for the repression of PEPCK gene transcription by insulin
29. Central role for PI 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin
30. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
31. Regulation of PEPCK gene expression by insulin: Use of the stable transfection approach to locate an insulin responsive sequence
32. 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase
33. A simplified system for generating recombinant adenoviruses
34. Specificity and mechanism of action of some commonly used protein kinase inhibitors
35. Regulation of the phosphoenolpyruvate carboxykinase gene by insulin
36. Lithium inhibits hepatic gluconeogenesis and PEPCK gene expression
37. In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain
38. Demonstration of inhibition of cAMP accumulation in brain by very low concentrations of lithium in the presence of alpha-adrenoceptor blockade
39. Neural and developmental actions of lithium: A unifying hypothesis
40. Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activity by GSK-3
41. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
42. A secondary phopshorylation of CREB at Ser-129 is required for the cAMP-mediated control of gene expression: A role for GSK-3 in the control of gene expression
43. GSK-3 is an insulin-regulated C/EBPα kinase
44. Nuclear export of NFATc enhanced by GSK-3
45. Down-regulation of b-catenin by human axin and its association with the APC tumor suppressor, b-catenin and GSK-3b
46. Negative regulation of jun/AP-1: Conserved function of GSK-3 and shaggy
47. GSK-3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells
48. A tripartite array of transcription factor binding sites mediates cAMP induction of PEPCK gene transcription and its inhibition by insulin
49. Insulin suppresses transactivation by C/EBPβ: Signaling to p300/CBP by protein kinase B disrupts interaction with the major activation domain of C/EBPβ
50. A multicomponent IRS mediates a strong repression of mouse G-6-Pase gene transcription by insulin
51. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: Transcription factor FKHR binds the insulin response sequence
52. HNF-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse G-6-Pase gene transcription
53. Inhibitors of signaling identify differential control processes responsible for selective effects of insulin on the expression of PEPCK and gene 33 in rat H4 hepatoma cells
54. Dominant negative forms of Akt and atypical PKCl do not prevent insulin inhibition of PEPCK gene transcription
55. Activation of PKB/Akt is sufficient to repress the glucocorticoid and cAMP induction of PEPCK gene
56. Assessment of the roles of MAPK, PI 3-kinase, PKB, and PKC in insulin inhibition of cAMP-induced PEPCK gene transcription
57. Phosphorylation of Set 256 by PKB disrupts transactivation by FKHR and mediates effects of insulin on IGFBP-1 promoter activity through a conserved insulin response sequence
58. The effect of phorbol esters and diacylglycerols on expression of the PEPCK (GTP) gene in rat hepatoma H4IIE cells
59. Differential regulation of glycogen synthase kinase-3β by protein kinase C isotopes
60. Inactivation of GSK-3 by EGF is mediated by MAP kinase/p90 RSK signalling pathway in NIH/3T3 cells
61. Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3-cells
62. Phosphorylation of the transcription factor forkhead family member FKHR by PKB
63. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway
64. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
65. Direct control of the forkhead transcription factor AFX by protein kinase B
66. Negative regulation of the forkhead transcription factor FKHR by Akt
67. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
68. Phosphorylation of IRS-1 by glycogen synthase kinase-3 impairs insulin action