Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation

British Journal of Pharmacology

Volumn 167, Issue 1, 2012, Pages 109-127

  Endale, M ^a   Lee, W M ^a   Kamruzzaman, S M ^a   Kim, S D ^a   Park, J Y ^a   Park, M H ^b   Park, T Y ^b   Park, H J ^c   Cho, J Y ^d   Rhee, M H ^a  

^a Kyungpook National University   (South Korea)

^b Ambo Institute   (South Korea)

^c Inje University   (South Korea)

^d Sungkyunkwan University   (South Korea)

Author keywords

ginsenoside Rp1; GPVI; PI3K; platelet; thrombus; tyrosine phosphorylation

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CALCIUM ION; COLLAGEN; CYCLIC AMP; DIHYDROGINSENOSIDE RG 3; FIBRINOGEN RECEPTOR; GINSENOSIDE; GINSENOSIDE RG 3; GINSENOSIDE RP 1; GLYCOPROTEIN VI; LAT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE SYK; THROMBIN; THROMBOXANE; TYROSINE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT THROMBUS; ARTICLE; BLEEDING; BLOOD CLOTTING TIME; CALCIUM MOBILIZATION; CELL GRANULE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOGENESIS; THROMBUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD COAGULATION; CALCIUM; CELL ADHESION MOLECULES; COLLAGEN; CYCLIC AMP; CYCLIC GMP; GINSENOSIDES; MALE; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; P-SELECTIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS; THROMBOXANE A2; TYROSINE;

EID: 84864697231     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01967.x     Document Type: Article

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