Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

Journal of Thrombosis and Haemostasis

Volumn 1, Issue 5, 2003, Pages 1079-1088

  Hubbard, G P ^a   Stevens, J M ^a   Cicmil, M ^a   Sage, T ^a   Jordan, P A ^a   Williams, C M ^a   Lovegrove, J A ^a   Gibbins, J M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Collagen; GPVI; Platelets; Quercetin

Indexed keywords

EID: 2442543550     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1046/j.1538-7836.2003.00212.x     Document Type: Article

References (33)

1. Takahashi H, Hanano M, Moroi M, Shibata A. Platelet membrane glycoprotein-VI (GPVI) is necessary for collagen-induced aggregation and adhesion and anti-GP-VI antibody induces platelet-aggregation- an evidence obtained from a patient with systemic lupus-erythematosus. Thromb Haemost 1995; 73: 1197.
2. Nieuwenhuis HK, Akkerman JWN, Houdijk WPM, Sixma JJ. Humanblood platelets showing no response to collagen fail to express surface glycoprotein-Ia. Nature 1985; 318: 470-2.
3. Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagenstimulated platelets. J Biol Chem 1996; 271: 18095-9.
4. Poole A, Gibbins JM, Turner M, van Vugt MJ, van de Winkel JGJ, Saito T, Tybulewicz VLJ,Watson SP. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 1997; 16: 2333-41.
5. Gibbins JM, Briddon S, Shutes A, van Vugt MJ, deWinkel JGJ, Saito T, Watson SP. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem 1998; 273: 34437-43.
6. Watson SP, Asazuma N, Atkinson B, Berlanga O, Best D, Bobe R, Jarvis G, Marshall S, Snell D, Stafford M, Tulasne D, Wilde J, Wonerow P, Frampton J. The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen. Thromb Haemost 2001; 86: 276-88.
7. Dsouza D, Wu KK, Hellums JD, Phillips MD. Platelet activation and arterial thrombosis. Lancet 1994; 344: 991-5.
8. Serebruany VL, Lowry DR, Fuzailov SY, Levine DJ, O'Connor CM, Gurbel PA. Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction. J Thromb Thrombolysis 2000; 9: 229-34.
9. Cerbone AM, Cirillo F, Coppola A, Rise P, Stragliotto E, Galli C, Giordano M, Tremoli E, Di Minno G. Persistent impairment of platelet aggregation following cessation of a short-course dietary supplementation of moderate amounts of n-3 fatty acid ethyl esters. Thromb Haemost 1999; 82: 128-33.
10. Calzada C, Bruckdorfer KR, RiceEvans CA. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997; 128: 97-105.
11. Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem 1992; 40: 2379-83.
12. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart-disease-the Zutphen Elderly Study. Lancet 1993; 342: 1007-11.
13. O'Reilly JD, Sanders TAB, Wiseman H. Flavonoids protect against oxidative damage to LDL in vitro: use in selection of a flavonoid rich diet and relevance to LDL oxidation resistance ex vivo? Free Radic Res 2000; 33: 419-26.
14. Zhao XY, Gu ZL, Attele AS, Yuan CS. Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture. J Ethnopharmacol 1999; 67: 279-85.
15. Beretz A, Cazenave JP, Anton R. Inhibition of aggregation and secretion of human-platelets by quercetin and other flavonoids-structure activity relationships. Agents Actions 1982; 12: 382-7.
16. Landolfi R, Mower RL, Steiner M. Modification of platelet-function and arachidonic-acid metabolism by bioflavonoids-structure activity relations. Biochem Pharmacol 1984; 33: 1525-30.
17. Tzeng SH, Ko WC, Ko FN, Teng CM. Inhibition of platelet-aggregation by some flavonoids. Thromb Res 1991; 64: 91-100.
18. Cicmil M, Thomas JM, Sage T, Barry FA, Leduc M, Bon C, Gibbins JM. Collagen, convulxin and thrombin stimulate aggregationindependent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. J Biol Chem 2000; 275: 27339-47.
19. Cicmil M, Thomas JM, Leduc M, Bon C, Gibbins JM. PECAM-1 signalling inhibits the activation of human platelets. Blood 2002; 99: 137-44.
20. Yanaga F, Poole A, Asselin J, Blake R, Schieven G, Clark EA, Law C-L, Watson SP. Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fcg-IIA receptor. Biochem J 1995; 311: 471-8.
21. Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. Association of phosphatidylinositol kinase-activity with polyoma middle-T competent for transformation. Nature 1985; 315: 239-42.
22. Smith JB, Selak MA, Dangelmaier C, Daniei JL. Cytosolic calcium as a 2nd messenger for collagen-induced platelet responses. Biochem J 1992; 288: 925-9.
23. Gibbins JM, Okuma M, Farndale R, Barnes M,Watson SP. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma- chain. FEBS Lett 1997; 413: 255-9.
24. Pasquet JM, Gross B, Quek L, Asazuma N, Zhang WG, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE,Watson SP. LAT is required for tyrosine phosphorylation of phospholipase C gamma 2 and platelet activation by the collagen receptor GPVI. Mol Cell Biol 1999; 19: 8326-34.
25. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105.
26. Briddon SJ, Watson SP. Evidence for the involvement of p59 (fyn) and p53/56 (lyn) in collagen receptor signalling in human platelets. Biochem J 1999; 338: 203-9.
27. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood 2000; 96: 4246-53.
28. Keevil JG, Osman HE, Reed JD, Folts JD. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr 2000; 130: 53-6.
29. You KM, Jong HG, Kim HP. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch Pharm Res 1999; 22: 18-24.
30. LiuW, Liang NC. Inhibitory effect of disodium qurecetin-7 40-disulfate on aggregation of pig platelets induced by thrombin and its mechanism. Acta Pharmacol Sin 2000; 21: 737-41.
31. Hollman PCH, Bijsman M, van Gameren Y, Cnossen EPJ, de Vries JHM, Katan MB. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 1999; 31: 569-73.
32. Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, Payrastre B. Flavonoids and the inhibition of PKC and PI 3-kinase. General Pharmacol 1999; 32: 279-86.
33. Pignatelli P, Pulcinelli FM, Lenti L, Gazzaniga PP, Violi F. Hydrogen peroxide is involved in collagen-induced platelet activation. Blood 1998; 91: 484-90.