Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation

Thrombosis and Haemostasis

Volumn 92, Issue 6, 2004, Pages 1387-1393

  Kuliopulos, Athan ^a   Mohanlal, Ramon ^b   Covic, Lidija ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

Aspirin; p38 MAPK; Platelet function

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSALICYLIC ACID; APYRASE; ARACHIDONIC ACID; COLLAGEN; FC RECEPTOR; HEPARIN; INTEGRIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; RISTOCETIN; THROMBIN; THROMBIN RECEPTOR; THROMBOXANE; THROMBOXANE A2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; VON WILLEBRAND FACTOR; VX 702;

ADULT; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APYRASE; ASPIRIN; BLOOD PLATELETS; CALCIUM; CHROMATOGRAPHY, GEL; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEPARIN; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROTEIN ISOFORMS; TIME FACTORS;

EID: 10444220932     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH04-03-0187     Document Type: Article

References (25)

1. Lee JC, Laydon JT, McDonnell PC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-46.
2. Han J, Lee JD, Bibbs L, et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265: 808-11.
3. Rouse J, Cohen P, Trigon S, et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994; 78: 1027-37.
4. Jiang Y, Chen C, Li Z, Guo, et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem 1996; 271: 17920-6.
5. Jiang Y, Gram H, Zhao M, et al. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem 1997; 272: 30122-8.
6. Young PR, McLaughlin MM, Kumar S, et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. 1997; 272: 12116-21.
7. Lee JC, Kumar S, Griswold DE, et al. Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology 2000; 47: 185-201.
8. Kumar S, McDonnell PC, Gum RJ, et al. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997; 235: 533-8.
9. Wilson KP, Fitzgibbon MJ, Caron PR, et al. Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem 1996; 271: 27696-700.
10. Wang Z, Harkins, Ulevitch PC, Han RJ, et al. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A. 1997; 94: 2327-32.
11. Borsch-Haubold AG, Ghomashchi F, Pasquet S, et al. Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. Eur J Biochem 1999; 265: 195-203.
12. Kramer RM, Roberts EF, Strifter BA, et al. Thrombin induces activation of p38 MAP kinase in human platelets. J Biol Chem 1995; 270: 27395-8.
13. Kramer RM, Roberts EF, Um SL, et al. p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets. J Biol Chem 1996; 271: 27723-9.
14. Dangelmaier C, Jin J, Daniel JL, et al. The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets. Eur J Biochem 2000; 267: 2283-9.
15. Saklatvala J, Rawlinson L, Waller RJ, et al. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J Biol Chem 1996; 271: 6586-9.
16. Covic L, Gresser AL, Kuliopulos A. Biphasic Kinetics of Activation and Signaling for PAR1 and PAR4 Thrombin Receptors in Platelets. Biochemistry 2000; 39: 5458-67.
17. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
18. Song S, Freedman, J, Mody, M, and Lazarus, AH. p38 MAPK is activated but not necessary in porcine von Willebrand factor-dependent platelet activation. Br J Haematol 1999; 107: 532-38.
19. Vu T-KH, DT Hung, Wheaton VI, et al. Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Action. Cell 1991; 64: 1057-68.
20. Xu W-F, Andersen H, Whitmore TE, et al. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998; 95: 6642-6.
21. Kahn ML, Zheng Y-W, Huang W, et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-4.
22. Covic L, Singh C, Smith H, et al. Role of the PAR4 Thrombin Receptor in Stabilizing Platelet-Platelet Aggregates as revealed by a Patient with Hermansky-Pudlak Syndrome. Thromb Haemost 2002; 87: 722-7.
23. Lee DS, Bhatt DL, Moliterno DJ, et al. The combination of enoxaparin, glycoprotein IIb/IIIa inhibitors and an early invasive approach among acute coronary syndrome patients. J Invasive Cardiol 2004; 16: 46-51.
24. Jin J, Quinton TM, Zhang J, et al. Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. Blood 2002; 99:193-8.
25. Andre P, Delaney SM, LaRocca T, et al. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 2003; 112: 398-406.