A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations

European Journal of Pharmacology

Volumn 627, Issue 1-3, 2010, Pages 85-91

  Lee, Hyun Sub ^a   Kim, Sung Dae ^b   Lee, Whi Min ^b   Endale, Mehari ^b   Kamruzzaman, S M ^b   Oh, Won Jun ^b   Cho, Jae Youl ^c   Kim, Sang Keun ^d   Cho, Hyun Jeong ^e   Park, Hwa Jin ^a   Rhee, Man Hee ^b  

^a Inje University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Kangwon National University   (South Korea)

^d Chungnam National University   (South Korea)

^e Konyang University   (South Korea)

Author keywords

BAY 11 7082; cAMP; MAP kinase; Platelet; TXA2; VASP

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; COLLAGEN; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOBUTYLMETHYLXANTHINE; JANUS KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PADGEM PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THROMBIN; THROMBOXANE B2; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL SECRETION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; INHIBITION KINETICS; MALE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PLATELETS; CALCIUM; CELL ADHESION MOLECULES; COLLAGEN; CYCLIC AMP; CYCLIC GMP; GENE EXPRESSION REGULATION; INTRACELLULAR SPACE; MALE; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 8; NF-KAPPA B; NITRILES; P-SELECTIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; THROMBIN; THROMBOXANE A2;

EID: 73449084397     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.005     Document Type: Article

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