In silico prediction of antimalarial drug target candidates

International Journal for Parasitology: Drugs and Drug Resistance

Volumn 2, Issue , 2012, Pages 191-199

  Ludin, Philipp ^a,b   Woodcroft, Ben ^c   Ralph, Stuart A ^c   Mäser, Pascal ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Drug target; Gene essentiality; Phylogenomics; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; CALPAIN; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE 7; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DIHYDROPTEROATE SYNTHASE; DNA TOPOISOMERASE; EXONUCLEASE; FUMARATE HYDRATASE; G PROTEIN COUPLED RECEPTOR; GLUTAMATE DEHYDROGENASE; ION CHANNEL; LYSINE DECARBOXYLASE; MANNOSE PHOSPHATE ISOMERASE; NUDIX HYDROLASE; ORNITHINE OXOACID AMINOTRANSFERASE; PEPTIDES AND PROTEINS; PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); PHOSPHOENOLPYRUVATE CARBOXYLASE; PROTEIN DNAJ; PROTEOME; RNA HELICASE; RNA METHYLTRANSFERASE; SACCHAROMYCES CEREVISIAE PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; THIOREDOXIN; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TRIACYLGLYCEROL LIPASE; UNINDEXED DRUG;

ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; COMPUTER MODEL; DEBARYOMYCES HANSENII; DRUG TARGETING; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; KLUYVEROMYCES LACTIS; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENOMICS; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; PLASMODIUM YOELII; PRIORITY JOURNAL; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; YARROWIA LIPOLYTICA;

EID: 84864516366     PISSN: 22113207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2012.07.002     Document Type: Article

References (101)

1. Abdi A., Eschenlauer S., Reininger L., Doerig C. SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum. Cell. Mol. Life Sci. 2010, 67:3355-3369.
2. Adhikari S., Manthena P.V., Kota K.K., Karmahapatra S.K., Roy G., Saxena R., Uren A., Roy R. A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease. Mol. Cell. Biochem. 2012, 362:195-201.
3. Aguero F., Al-Lazikani B., Aslett M., Berriman M., Buckner F.S., Campbell R.K., Carmona S., Carruthers I.M., Chan A.W., Chen F., Crowther G.J., Doyle M.A., Hertz-Fowler C., Hopkins A.L., McAllister G., Nwaka S., Overington J.P., Pain A., Paolini G.V., Pieper U., Ralph S.A., Riechers A., Roos D.S., Sali A., Shanmugam D., Suzuki T., Van Voorhis W.C., Verlinde C.L. Genomic-scale prioritization of drug targets: the TDR Targets database. Nat. Rev. Drug Discov. 2008, 7:900-907.
4. Al-Lazikani, B., Gaulton, A., Paolini, G., Lanfear, J., Overington, J., Hopkins, A.L. (2007). The molecular basis of predicting druggability. In: Bioinformatics - From Genomes to Therapies. In: The Holy Grail: Molecular Function, vol. 3, Wiley, T.L. Weinheim, pp. 1315-1334.
5. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 1990, 215:403-410.
6. Aparicio I.M., Marin-Menendez A., Bell A., Engel P.C. Susceptibility of Plasmodium falciparum to glutamate dehydrogenase inhibitors-a possible new antimalarial target. Mol. Biochem. Parasitol. 2010, 172:152-155.
7. Armstrong C.M., Goldberg D.E. An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat. Methods 2007, 4:1007-1009.
8. Aurrecoechea C., Brestelli J., Brunk B.P., Dommer J., Fischer S., Gajria B., Gao X., Gingle A., Grant G., Harb O.S., Heiges M., Innamorato F., Iodice J., Kissinger J.C., Kraemer E., Li W., Miller J.A., Nayak V., Pennington C., Pinney D.F., Roos D.S., Ross C., Stoeckert C.J., Treatman C., Wang H. PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res. 2009, 37:D539-543.
9. Bapat A., Glass L.S., Luo M., Fishel M.L., Long E.C., Georgiadis M.M., Kelley M.R. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J. Pharmacol. Exp. Ther. 2010, 334:988-998.
10. Baum J., Papenfuss A.T., Mair G.R., Janse C.J., Vlachou D., Waters A.P., Cowman A.F., Crabb B.S., de Koning-Ward T.F. Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res. 2009, 37:3788-3798.
11. Beeckmans S., Van Driessche E. Pig heart fumarase contains two distinct substrate-binding sites differing in affinity. J. Biol. Chem. 1998, 273:31661-31669.
12. Branson K.M., Mertens H.D., Swarbrick J.D., Fletcher J.I., Kedzierski L., Gayler K.R., Gooley P.R., Smith B.J. Discovery of inhibitors of lupin diadenosine 5',5‴-P(1), P(4)-tetraphosphate hydrolase by virtual screening. Biochemistry 2009, 48:7614-7620.
13. Bulusu V., Jayaraman V., Balaram H. Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum. J. Biol. Chem. 2011, 286:9236-9245.
14. Charman S.A., Arbe-Barnes S., Bathurst I.C., Brun R., Campbell M., Charman W.N., Chiu F.C., Chollet J., Craft J.C., Creek D.J., Dong Y., Matile H., Maurer M., Morizzi J., Nguyen T., Papastogiannidis P., Scheurer C., Shackleford D.M., Sriraghavan K., Stingelin L., Tang Y., Urwyler H., Wang X., White K.L., Wittlin S., Zhou L., Vennerstrom J.L. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl. Acad. Sci. USA 2011, 108:4400-4405.
15. Chen H., Li Y., Tollefsbol T.O. Strategies targeting telomerase inhibition. Mol. Biotechnol. 2009, 41:194-199.
16. Coleman R.A. Hepatic sn-glycerol-3-phosphate acyltransferases: effect of monoacylglycerol analogs on mitochondrial and microsomal activities. Biochim. Biophys. Acta 1988, 963:367-374.
17. Coppi A., Tewari R., Bishop J.R., Bennett B.L., Lawrence R., Esko J.D., Billker O., Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe 2007, 2:316-327.
18. Crowther G.J., Shanmugam D., Carmona S.J., Doyle M.A., Hertz-Fowler C., Berriman M., Nwaka S., Ralph S.A., Roos D.S., Van Voorhis W.C., Aguero F. Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl. Trop. Dis. 2010, 4:e804.
19. Deng J., Deng L., Su S., Zhang M., Lin X., Wei L., Minai A.A., Hassett D.J., Lu L.J. Investigating the predictability of essential genes across distantly related organisms using an integrative approach. Nucleic Acids Res. 2010, 39:795-807.
20. Doyle M.A., Gasser R.B., Woodcroft B.J., Hall R.S., Ralph S.A. Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes. BMC Genomics 2010, 11:222.
21. Engel S.R., Balakrishnan R., Binkley G., Christie K.R., Costanzo M.C., Dwight S.S., Fisk D.G., Hirschman J.E., Hitz B.C., Hong E.L., Krieger C.J., Livstone M.S., Miyasato S.R., Nash R., Oughtred R., Park J., Skrzypek M.S., Weng S., Wong E.D., Dolinski K., Botstein D., Cherry J.M. Saccharomyces Genome Database provides mutant phenotype data. Nucleic Acids Res. 2010, 38:D433-436.
22. Fatumo S., Plaimas K., Mallm J.P., Schramm G., Adebiyi E., Oswald M., Eils R., Konig R. Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico. Infect. Genet. Evol. 2009, 9:351-358.
23. Fitzpatrick D.A., Logue M.E., Stajich J.E., Butler G. A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis. BMC Evol. Biol. 2006, 6:99.
24. Flint D.H. Initial kinetic and mechanistic characterization of Escherichia coli fumarase A. Arch. Biochem. Biophys. 1994, 311:509-516.
25. Foret J., de Courcy B., Gresh N., Piquemal J.P., Salmon L. Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases. Bioorg. Med. Chem. 2009, 17:7100-7107.
26. Frenal K., Polonais V., Marq J.B., Stratmann R., Limenitakis J., Soldati-Favre D. Functional dissection of the apicomplexan glideosome molecular architecture. Cell Host Microbe 2010, 8:343-357.
27. Gafan C., Wilson J., Berger L.C., Berger B.J. Characterization of the ornithine aminotransferase from Plasmodium falciparum. Mol. Biochem. Parasitol. 2001, 118:1-10.
28. Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K., Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419:498-511.
29. Gaulton A., Bellis L.J., Bento A.P., Chambers J., Davies M., Hersey A., Light Y., McGlinchey S., Michalovich D., Al-Lazikani B., Overington J.P. ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2012, 40:D1100-1107.
30. Guranowski A., Starzynska E., McLennan A.G., Baraniak J., Stec W.J. Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. Biochem. J. 2003, 373:635-640.
31. Guranowski A., Starzynska E., Pietrowska-Borek M., Rejman D., Blackburn G.M. Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases. FEBS J. 2009, 276:1546-1553.
32. Haltiwanger B.M., Karpinich N.O., Taraschi T.F. Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum. Biochem. J. 2000, 345(Pt 1):85-89.
33. Hannay K., Marcotte E.M., Vogel C. Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. BMC Genomics 2008, 9:609.
34. Hayward R.E. Plasmodium falciparum phosphoenolpyruvate carboxykinase is developmentally regulated in gametocytes. Mol. Biochem. Parasitol. 2000, 107:227-240.
35. Holman A.G., Davis P.J., Foster J.M., Carlow C.K., Kumar S. Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi. BMC Microbiol. 2009, 9:243.
36. Hopkins A.L., Groom C.R. The druggable genome. Nat. Rev. Drug Discov. 2002, 1:727-730.
37. Hopkins A.L., Bickerton G.R., Carruthers I.M., Boyer S.K., Rubin H., Overington J.P. Rapid analysis of pharmacology for infectious diseases. Curr. Top. Med. Chem. 2011, 11:1292-1300.
38. Huthmacher C., Hoppe A., Bulik S., Holzhutter H.G. Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. BMC Syst. Biol. 2010, 4:120.
39. Janse C.J., Kroeze H., van Wigcheren A., Mededovic S., Fonager J., Franke-Fayard B., Waters A.P., Khan S.M. A genotype and phenotype database of genetically modified malaria-parasites. Trends Parasitol. 2011, 27:31-39.
40. Jenkins C.L. Effects of the phosphoenolpyruvate carboxylase inhibitor 3,3-dichloro-2-(dihydroxyphosphinoylmethyl)propenoate on photosynthesis: C(4) selectivity and studies on C(4) photosynthesis. Plant Physiol. 1989, 89:1231-1237.
41. Joubert F., Harrison C.M., Koegelenberg R.J., Odendaal C.J., de Beer T.A. Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria. Malar. J. 2009, 8:178.
42. Joyce A.R., Palsson B.O. Predicting gene essentiality using genome-scale in silico models. Methods Mol. Biol. 2008, 416:433-457.
43. Kato N., Sakata T., Breton G., Le Roch K.G., Nagle A., Andersen C., Bursulaya B., Henson K., Johnson J., Kumar K.A., Marr F., Mason D., McNamara C., Plouffe D., Ramachandran V., Spooner M., Tuntland T., Zhou Y., Peters E.C., Chatterjee A., Schultz P.G., Ward G.E., Gray N., Harper J., Winzeler E.A. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat. Chem. Biol. 2008, 4:347-356.
44. Kobayashi T., Takematsu H., Yamaji T., Hiramoto S., Kozutsumi Y. Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast. J. Biol. Chem. 2005, 280:18087-18094.
45. Le Roch K.G., Zhou Y., Blair P.L., Grainger M., Moch J.K., Haynes J.D., De La Vega P., Holder A.A., Batalov S., Carucci D.J., Winzeler E.A. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 2003, 301:1503-1508.
46. Leber W., Skippen A., Fivelman Q.L., Bowyer P.W., Cockcroft S., Baker D.A. A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum. Int. J. Parasitol. 2009, 39:645-653.
47. Levillain O., Diaz J.J., Reymond I., Soulet D. Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase. Pflugers Arch. 2000, 440:761-769.
48. Li M., Allen A., Smith T.J. High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors. Biochemistry 2007, 46:15089-15102.
49. Li M., Smith C.J., Walker M.T., Smith T.J. Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. J. Biol. Chem. 2009, 284:22988-23000.
50. Lim D.C., Cooke B.M., Doerig C., Saeij J.P. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int. J. Parasitol. 2012, 42:21-32.
51. Llinas M., DeRisi J.L. Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis. Curr. Opin. Microbiol. 2004, 7:382-387.
52. Madhusudana Rao.I., Swamy P.M., Das V.S.R. Herbricide (sic) inhibited phosphoenolpyruvate carboxylase in leaves of six nonsucculent scrub species. Z. Pflanzenphysiol 1980, 99:69-74.
53. Magarinos M.P., Carmona S.J., Crowther G.J., Ralph S.A., Roos D.S., Shanmugam D., Van Voorhis W.C., Aguero F. TDR Targets: a chemogenomics resource for neglected diseases. Nucleic Acids Res. 2012, 40:D1118-1127.
54. Magrane, M., Consortium, U., 2011. UniProt Knowledgebase: A Hub of Integrated Protein Data. Database, Oxford, bar009.
55. Martinsen E.S., Perkins S.L., Schall J.J. A three-genome phylogeny of malaria parasites (Plasmodium and closely related genera): evolution of life-history traits and host switches. Mol. Phylogenet. Evol. 2008, 47:261-273.
56. Mastrolorenzo A., Scozzafava A., Supuran C.T. Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives. J. Enzym. Inhib. 2000, 15:517-531.
57. McDaniel H.G., Siu P.M. Purification and characterization of phosphoenolpyruvate carboxylase from Plasmodium berghei. J. Bacteriol. 1972, 109:385-390.
58. Mulder N.J., Kersey P., Pruess M., Apweiler R. In silico characterization of proteins: UniProt, InterPro and Integr8. Mol. Biotechnol. 2008, 38:165-177.
59. Muller I.B., Hyde J.E. Antimalarial drugs: modes of action and mechanisms of parasite resistance. Future Microbiol. 2010, 5:1857-1873.
60. Needleman S.B., Wunsch C.D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 1970, 48:443-453.
61. Ojo K.K., Larson E.T., Keyloun K.R., Castaneda L.J., Derocher A.E., Inampudi K.K., Kim J.E., Arakaki T.L., Murphy R.C., Zhang L., Napuli A.J., Maly D.J., Verlinde C.L., Buckner F.S., Parsons M., Hol W.G., Merritt E.A., Van Voorhis W.C. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat. Struct. Mol. Biol. 2010, 17:602-607.
62. Onyango D.O., Naguleswaran A., Delaplane S., Reed A., Kelley M.R., Georgiadis M.M., Sullivan W.J. Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii. DNA Repair (Amst.) 2011, 10:466-475.
63. Ostlund G., Schmitt T., Forslund K., Kostler T., Messina D.N., Roopra S., Frings O., Sonnhammer E.L. InParanoid 7: new algorithms and tools for eukaryotic orthology analysis. Nucleic Acids Res. 2010, 38:D196-203.
64. Pairoba C.F., Colombo S.L., Andreo C.S. Flavonoids as inhibitors of NADP-malic enzyme and PEP carboxylase from C4 plants. Biosci. Biotechnol. Biochem. 1996, 60:779-783.
65. Payne D.J., Holmes D.J., Rosenberg M. Delivering novel targets and antibiotics from genomics. Curr. Opin. Investig. Drugs 2001, 2:1028-1034.
66. Plata G., Hsiao T.L., Olszewski K.L., Llinas M., Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol. Syst. Biol. 2010, 6:408.
67. Rice P., Longden I., Bleasby A. EMBOSS: the European molecular biology open software suite. Trends Genet. 2000, 16:276-277.
68. Riguet E., Desire J., Boden O., Ludwig V., Gobel M., Bailly C., Decout J.L. Neamine dimers targeting the HIV-1 TAR RNA. Bioorg. Med. Chem. Lett. 2005, 15:4651-4655.
69. Rodriguez-Acosta A., de Dominguez N., Aguilar I., Giron M.E. Detection of glutamate dehydrogenase enzyme activity in Plasmodium falciparum infection. Indian J. Med. Res. 1999, 109:152-156.
70. Rohrich R.C., Englert N., Troschke K., Reichenberg A., Hintz M., Seeber F., Balconi E., Aliverti A., Zanetti G., Kohler U., Pfeiffer M., Beck E., Jomaa H., Wiesner J. Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. FEBS Lett. 2005, 579:6433-6438.
71. Rottmann M., McNamara C., Yeung B.K., Lee M.C., Zou B., Russell B., Seitz P., Plouffe D.M., Dharia N.V., Tan J., Cohen S.B., Spencer K.R., Gonzalez-Paez G.E., Lakshminarayana S.B., Goh A., Suwanarusk R., Jegla T., Schmitt E.K., Beck H.P., Brun R., Nosten F., Renia L., Dartois V., Keller T.H., Fidock D.A., Winzeler E.A., Diagana T.T. Spiroindolones, a potent compound class for the treatment of malaria. Science 2010, 329:1175-1180.
72. Sa J.M., Chong J.L., Wellems T.E. Malaria drug resistance: new observations and developments. Essays Biochem. 2011, 51:137-160.
73. Salvati L., Mattu M., Tiberi F., Polticelli F., Ascenzi P. Inhibition of Saccharomyces cerevisiae phosphomannose isomerase by the NO-donor S-nitroso-acetyl-penicillamine. J. Enzym. Inhib. 2001, 16:287-292.
74. Santiago T.C., Zufferey R., Mehra R.S., Coleman R.A., Mamoun C.B. The Plasmodium falciparum PfGatp is an endoplasmic reticulum membrane protein important for the initial step of malarial glycerolipid synthesis. J. Biol. Chem. 2004, 279:9222-9232.
75. Satchell J.F., Malby R.L., Luo C.S., Adisa A., Alpyurek A.E., Klonis N., Smith B.J., Tilley L., Colman P.M. Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Acta Crystallogr. D: Biol. Crystallogr. 2005, 61:1213-1221.
76. Scheer M., Grote A., Chang A., Schomburg I., Munaretto C., Rother M., Sohngen C., Stelzer M., Thiele J., Schomburg D. BRENDA, the enzyme information system in 2011. Nucleic Acids Res. 2011, 39:D670-676.
77. Schindelman G., Fernandes J.S., Bastiani C.A., Yook K., Sternberg P.W. Worm Phenotype Ontology: integrating phenotype data within and beyond the C. elegans community. BMC Bioinform. 2011, 12:32.
78. Sriwilaijareon N., Petmitr S., Mutirangura A., Ponglikitmongkol M., Wilairat P. Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol. Int. 2002, 51:99-103.
79. Storm J., Perner J., Aparicio I., Patzewitz E.M., Olszewski K., Llinas M., Engel P.C., Muller S. Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malar. J. 2011, 10:193.
80. Stranska J., Kopecny D., Tylichova M., Snegaroff J., Sebela M. Ornithine delta-aminotransferase: an enzyme implicated in salt tolerance in higher plants. Plant Signal. Behav. 2008, 3:929-935.
81. Strecker H.J. Purification and properties of rat liver ornithine delta-transaminase. J. Biol. Chem. 1965, 240:1225-1230.
82. Takatsuka Y., Onoda M., Sugiyama T., Muramoto K., Tomita T., Kamio Y. Novel characteristics of Selenomonas ruminantium lysine decarboxylase capable of decarboxylating both l-lysine and l-ornithine. Biosci. Biotechnol. Biochem. 1999, 63:1063-1069.
83. Teixeira C., Gomes J.R., Gomes P. Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malaria. Curr. Med. Chem. 2011, 18:1555-1572.
84. Tell G., Fantini D., Quadrifoglio F. Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment. Cell. Mol. Life Sci. 2010, 67:3589-3608.
85. Tewari R., Straschil U., Bateman A., Bohme U., Cherevach I., Gong P., Pain A., Billker O. The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host Microbe 2010, 8:377-387.
86. Triglia T., Wang P., Sims P.F.G., Hyde J., Cowman A. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 1998, 17:3807-3815.
87. van Dooren G.G., Su V., D'Ombrain M.C., McFadden G.I. Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme. J. Biol. Chem. 2002, 277:23612-23619.
88. Vinayak S., Sharma Y.D. Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme. Oligonucleotides 2007, 17:189-200.
89. Wang G., Shang L., Burgett A.W., Harran P.G., Wang X. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc. Natl. Acad. Sci. USA 2007, 104:2068-2073.
90. Wang P., Wang Q., Aspinall T.V., Sims P.F., Hyde J.E. Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. Mol. Microbiol. 2004, 51:1425-1438.
91. Wang P., Wang Q., Yang Y., Coward J.K., Nzila A., Sims P.F., Hyde J.E. Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. Mol. Biochem. Parasitol. 2010, 172:41-51.
92. Waterhouse R.M., Zdobnov E.M., Kriventseva E.V. Correlating traits of gene retention, sequence divergence, duplicability and essentiality in vertebrates, arthropods, and fungi. Genome Biol. Evol. 2010, 3:75-86.
93. Wells T.N., Scully P., Paravicini G., Proudfoot A.E., Payton M.A. Mechanism of irreversible inactivation of phosphomannose isomerases by silver ions and flamazine. Biochemistry 1995, 34:7896-7903.
94. Wills E.A., Roberts I.S., Del Poeta M., Rivera J., Casadevall A., Cox G.M., Perfect J.R. Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. Mol. Microbiol. 2001, 40:610-620.
95. Winzeler E.A., Shoemaker D.D., Astromoff A., Liang H., Anderson K., Andre B., Bangham R., Benito R., Boeke J.D., Bussey H., Chu A.M., Connelly C., Davis K., Dietrich F., Dow S.W., El Bakkoury M., Foury F., Friend S.H., Gentalen E., Giaever G., Hegemann J.H., Jones T., Laub M., Liao H., Liebundguth N., Lockhart D.J., Lucau-Danila A., Lussier M., M'Rabet N., Menard P., Mittmann M., Pai C., Rebischung C., Revuelta J.L., Riles L., Roberts C.J., Ross-MacDonald P., Scherens B., Snyder M., Sookhai-Mahadeo S., Storms R.K., Veronneau S., Voet M., Volckaert G., Ward T.R., Wysocki R., Yen G.S., Yu K., Zimmermann K., Philippsen P., Johnston M., Davis R.W. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999, 285:901-906.
96. Wydysh E.A., Medghalchi S.M., Vadlamudi A., Townsend C.A. Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors. J. Med. Chem. 2009, 52:3317-3327.
97. Yamamoto S., Imamura T., Kusaba K., Shinoda S. Purification and some properties of inducible lysine decarboxylase from Vibrio parahaemolyticus. Chem. Pharm. Bull. (Tokyo) 1991, 39:3067-3070.
98. Yamashita, S., Numa, S., 1981. Glycerophosphate acyltransferase from rat liver. Methods Enzymol. 71 (Pt C), pp. 550-554.
99. Yeh I., Hanekamp T., Tsoka S., Karp P.D., Altman R.B. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004, 14:917-924.
100. Zawahir Z., Dayam R., Deng J., Pereira C., Neamati N. Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors. J. Med. Chem. 2009, 52:20-32.
101. Zhang K., Rathod P.K. Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science 2002, 296:545-547.