Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 10, 2009, Pages 3317-3327

  Wydysh, Edward A ^a   Medghalchi, Susan M ^a   Vadlamudi, Aravinda ^a   Townsendd, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLOROPHENYLSULFONAMIDO)BENZOIC ACID; 2 (NONYLSULFONAMIDE)BENZOIC ACID; 2 (NONYLSULFONAMIDO)BENZOIC ACID; 2 (NONYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 2 (PENTYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 2 (PHENYLMETHYLSULFONAMIDO)BENZOIC ACID; 2 (PHENYLSULFONAMIDO)BENZOIC ACID; 3 (2 PHENYLETHYLSULFONAMIDO)BENZOIC ACID; 3 (4 CHLOROPHENYLSULFONAMIDO)BENZOIC ACID; 3 (NONYLSULFONAMIDO)BENZOIC ACID; 3 (NONYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 3 (NONYLSULFONAMIDOMETHYL)BENZOIC ACID; 3 (PENTYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 3 (PENTYLSULFONAMIDOMETHYL)BENZOIC ACID; 3 (PHENYLMETHYLSULFONAMIDO)BENZOIC ACID; 3 (PHENYLSULFONAMIDO)BENZOIC ACID; 4 (2 PHENYLMETHYLSULFONAMIDO)BENZOIC ACID; 4 (4 CHLOROPHENYLSULFONAMIDO)BENZOIC ACID; 4 (NONYLSULFONAMIDO)BENZOIC ACID; 4 (NONYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 4 (NONYLSULFONAMIDOMETHYL)BENZOIC ACID; 4 (PENTYLSULFONAMIDO)BENZYLPHOSPHONIC ACID; 4 (PENTYLSULFONAMIDOMETHYL)BENZOIC ACID; 4 (PHENYLMETHYLSULFONAMIDO)BENZOIC ACID; 4 (PHENYLSULFONAMIDO)BENZOIC ACID; BENZOIC ACID; ENZYME INHIBITOR; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

ACYLATION; ANIMALS; BENZOIC ACIDS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GLYCERIDES; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; GLYCEROPHOSPHATES; MICE; MITOCHONDRIA; OBESITY; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66249135257     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900251a     Document Type: Article

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