Pig heart fumarase contains two distinct substrate-binding sites differing in affinity

Journal of Biological Chemistry

Volumn 273, Issue 48, 1999, Pages 31661-31669

  Beeckmans, Sonia ^a   Van Driessche, Edilbert ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; FUMARATE HYDRATASE; FUMARIC ACID; MALIC ACID; METHIONINE; OXALOACETIC ACID; TYROSINE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; SWINE; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; FUMARATE HYDRATASE; FUMARATES; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; MALATES; MODELS, MOLECULAR; MOLECULAR WEIGHT; MYOCARDIUM; PROTEIN DENATURATION; SPECTROPHOTOMETRY; SWINE; UREA;

ANIMALIA; EUKARYOTA; SUS SCROFA;

EID: 0033610885     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.48.31661     Document Type: Article

References (10)

1. Hill, R. L., and Teipel, J. W. (1971) The Enzymes (Boyer, P. D., ed) 3rd Ed., Vol. 5, pp. 539-571, Academic Press, New York
2. Suzuki, T., Sato, M., Yoshida, T., and Tuboi, S. (1989) J. Biol. Chem. 264, 2581-2586
3. Suzuki, T., Yoshida, T., and Tuboi, S. (1992) Eur. J. Biochem. 207, 767-772
4. Wu, M., and Tzagoloff, A. (1987) J. Biol. Chem. 262, 12275-12282
5. Weaver, T. M., Levitt, D. G., Donnelly, M. I., Wilkens Stevens, P. P., and Banaszak, L. J. (1995) Nat. Struct. Biol. 2, 654-662
6. Weaver, T., and Banaszak, L. (1996) Biochemistry 35, 13955-13965
7. Weaver, T., Lees, M., and Banaszak, L. (1997) Protein Sci. 6, 834-842
8. Porter, D. J. T., and Bright, H. J. (1980) J. Biol. Chem. 253, 4772-4780
9. Blanchard, J. S., and Cleland, W. W. (1980) Biochemistry 19, 4506-4513
10. Hansen, J. N., Dinovo, E. C., and Boyer, P. D. (1969) J. Biol. Chem. 244, 6270-6279