Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

Molecular and Biochemical Parasitology

Volumn 172, Issue 1, 2010, Pages 41-51

  Wang, Ping ^a   Wang, Qi ^a   Yang, Yonghong ^b,d   Coward, James K ^b   Nzila, Alexis ^c   Sims, Paul F G ^a   Hyde, John E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

^c KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^d CARESTREAM HEALTH INC   (United States)

Author keywords

Antifolate inhibitor studies; Biphasic kinetics; Folate metabolism; Methotrexate; Phosphinate analogues of folate; Substrate specificity

Indexed keywords

7,8 DIHYDROFOLIC ACID; ADENOSINE TRIPHOSPHATE; DIHYDROFOLATE SYNTHETASE; DIHYDROFOLIC ACID; DIHYDROPTEROATE SYNTHASE; FOLIC ACID ANTAGONIST; FOLIC ACID DERIVATIVE; FOLYLPOLYGLUTAMATE SYNTHASE; GLUTAMIC ACID; METHOTREXATE; PTERIN; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; MICHAELIS MENTEN KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITORS; FOLIC ACID; GLUTAMIC ACID; KINETICS; METHOTREXATE; PEPTIDE SYNTHASES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PTERINS; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATES;

EUKARYOTA; PLASMODIUM FALCIPARUM;

EID: 77952553020     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.03.012     Document Type: Article

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