Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico

Infection, Genetics and Evolution

Volumn 9, Issue 3, 2009, Pages 351-358

  Fatumo, Segun ^a   Plaimas, Kitiporn ^b   Mallm, Jan Philipp ^b   Schramm, Gunnar ^c   Adebiyi, Ezekiel ^a   Oswald, Marcus ^b   Eils, Roland ^b,c   König, Rainer ^b,c  

^a Centre for Economic Policy and Development Research   (Nigeria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Breadth first search; Drug targets; Knock out; Malaria; Metabolic network; Plasmodium

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ADENOSINE DEAMINASE; ADENOSYLHOMOCYSTEINASE; ADENOSYLMETHIONINE DECARBOXYLASE; ANTIMALARIAL AGENT; CHOLINE KINASE; DIHYDROFOLATE REDUCTASE; DIHYDROOROTATE OXIDASE; DIHYDROPTEROATE SYNTHASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUTATHIONE TRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINATE DEHYDROGENASE; INOSITOL 1,4,5 TRISPHOSPHATE 5 PHOSPHATASE; ORNITHINE DECARBOXYLASE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; PURINE NUCLEOSIDE PHOSPHORYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE; SPERMIDINE SYNTHASE; SPHINGOMYELIN PHOSPHODIESTERASE; SQUALENE SYNTHASE; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); THYMIDYLATE SYNTHASE;

ACCURACY; ARTICLE; BIOCHEMISTRY; COMPUTER MODEL; DRUG RESEARCH; DRUG TARGETING; KNOCKOUT GENE; MATHEMATICAL COMPUTING; NONHUMAN; PLASMODIUM FALCIPARUM; PREDICTION; PRIORITY JOURNAL; PROTEIN METABOLISM; QUALITATIVE ANALYSIS;

ALGORITHMS; ANIMALS; AUTOMATIC DATA PROCESSING; DRUG DISCOVERY; HUMANS; MALARIA, FALCIPARUM; METABOLIC NETWORKS AND PATHWAYS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 64549142857     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meegid.2008.01.007     Document Type: Article

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