PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity

Molecules and Cells

Volumn 34, Issue 1, 2012, Pages 7-13

  Koh, Hyongjong ^a   Chung, Jongkyeong ^b  

^a Dong A University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Drosophila; FOXO; mitochondrial dysfunction; Parkin; Parkinson's disease; PINK1; Sir2

Indexed keywords

MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; PARKIN; PINK1; SILENT INFORMATION REGULATOR PROTEIN 2; TRANSCRIPTION FACTOR FOXO; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL FUNCTION; CELL MIGRATION; CELL PROTECTION; CELL TRANSPORT; CYTOLOGY; CYTOSOL; DOPAMINERGIC NERVE CELL; DOWNSTREAM PROCESSING; DROSOPHILA; GENETIC ANALYSIS; HUMAN; MITOCHONDRION; MODEL; MUTANT; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PROTEIN PHOSPHORYLATION; QUALITY CONTROL; REVIEW; UBIQUITINATION; ZEBRA FISH;

ANIMALS; DROSOPHILA PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HISTONE DEACETYLASES; HUMANS; MITOCHONDRIA; MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; SIRTUINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84864471700     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-012-0100-8     Document Type: Review

References (82)

1. T. Araki Y. Sasaki J. Milbrandt 2004 Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 1010 1013 15310905 10.1126/science.1098014 1:CAS:528:DC%2BD2cXmsVGmsbc%3D (Pubitemid 39071777)
2. R. Betarbet T.B. Sherer G. MacKenzie M. Garcia-Osuna A.V. Panov J.T. Greenamyre 2000 Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nat. Neurosci. 3 1301 1306 11100151 10.1038/81834 1:CAS:528:DC%2BD3cXosVGgsbg%3D
3. F. Billia L. Hauck F. Konecny V. Rao J. Shen T.W. Mak 2011 PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function Proc. Natl. Acad. Sci. USA 108 9572 9577 21606348 10.1073/pnas.1106291108 1:CAS:528:DC%2BC3MXnslGkur4%3D
4. V. Bonifati P. Rizzu M.J. van Baren O. Schaap G.J. Breedveld E. Krieger M.C.J. Dekker F. Squitieri P. Ibanez M. Joosse, et al. 2003 Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism Science 299 256 259 12446870 10.1126/science.1077209 1:CAS:528:DC%2BD3sXhs1Gkuw%3D%3D (Pubitemid 36131051)
5. A.I. Brooks C.A. Chadwick H.A. Gelbard D.A. Cory-Slechta H.J. Federoff 1999 Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss Brain Res. 823 1 10 10095006 10.1016/S0006-8993(98)01192-5 1:CAS:528:DyaK1MXhvVCntrw%3D (Pubitemid 29225488)
6. A. Brunet L.B. Sweeney J.F. Sturgill K.F. Chua P.L. Greer Y.X. Lin H. Tran S.E. Ross R. Mostoslavsky H.Y. Cohen, et al. 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2011 2015 14976264 10.1126/science.1094637 1:CAS:528:DC%2BD2cXisVGlt70%3D (Pubitemid 38393275)
7. G.H. Cha S. Kim J. Park E. Lee M. Kim S.B. Lee J.M. Kim J. Chung K.S. Cho 2005 Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila Proc. Natl. Acad. Sci. USA 102 10345 10350 16002472 10.1073/pnas.0500346102 1:CAS:528:DC%2BD2MXmvVeksL4%3D (Pubitemid 41023373)
8. N.C. Chan A.M. Salazar A.H. Pham M.J. Sweredoski N.J. Kolawa R.L.J. Graham S. Hess D.C. Chan 2011 Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy Hum. Mol. Genet. 20 1726 1737 21296869 10.1093/hmg/ddr048 1:CAS:528:DC%2BC3MXksFSku7Y%3D
9. I.E. Clark M.W. Dodson C.G. Jiang J.H. Cao J.R. Huh J.H. Seol S.J. Yoo B.A. Hay M. Guo 2006 Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 1162 1166 16672981 10.1038/nature04779 1:CAS:528:DC%2BD28Xmtlaiu78%3D (Pubitemid 43990738)
10. H. Coulom S. Birman 2004 Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster J. Neurosci. 24 10993 10998 15574749 10.1523/JNEUROSCI.2993-04.2004 1:CAS:528:DC%2BD2cXhtFShu77F (Pubitemid 39602410)
11. H. Daitoku M. Hatta H. Matsuzaki S. Aratani T. Ohshima M. Miyagishi T. Nakajima A. Fukamizu 2004 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. USA 101 10042 10047 15220471 10.1073/pnas.0400593101 1:CAS:528: DC%2BD2cXlvFOhsr0%3D (Pubitemid 38891191)
12. T.M. Dawson 2006 Parkin and defective ubiquitination in Parkinson's disease J. Neural Transm. Suppl. 70 209 213 17017531 10.1007/978-3-211-45295-0- 32 1:CAS:528:DC%2BD28Xht1WjsrbJ (Pubitemid 44622201)
13. E. Deas H. Plun-Favreau S. Gandhi H. Desmond S. Kjaer S.H.Y. Loh A.E.M. Renton R.J. Harvey A.J. Whitworth L.M. Martins, et al. 2011 PINK1 cleavage at position A103 by the mitochondrial protease PARL Hum. Mol. Genet. 20 867 879 21138942 10.1093/hmg/ddq526 1:CAS:528:DC%2BC3MXhsFylsLw%3D
14. H. Deng J. Jankovic Y. Guo W.J. Xie W.D. Le 2005 Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y Biochem. Biophys. Res. Commun. 337 1133 1138 16226715 10.1016/j.bbrc.2005.09.178 1:CAS:528:DC%2BD2MXhtFKhs7bN (Pubitemid 41505244)
15. H.S. Deng M.W. Dodson H.X. Huang M. Guo 2008 The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila Proc. Natl. Acad. Sci. USA 105 14503 14508 18799731 10.1073/pnas.0803998105 1:CAS:528:DC%2BD1cXht1SgtrfL
16. N. Exner B. Treske D. Paquet K. Holmstrom C. Schiesling S. Gispert I. Carballo-Carbajal D. Berg H.H. Hoepken T. Gasser, et al. 2007 Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin J. Neurosci. 27 12413 12418 17989306 10.1523/JNEUROSCI.0719-07.2007 1:CAS:528:DC%2BD2sXhtlartLbK (Pubitemid 350085485)
17. L.W.S. Finley M.C. Haigis 2009 The coordination of nuclear and mitochondrial communication during aging and calorie restriction Ageing Res. Rev. 8 173 188 19491041 10.1016/j.arr.2009.03.003 1:CAS:528:DC%2BD1MXptVKrtLw%3D
18. C.A. Gautier T. Kitada J. Shen 2008 Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress Proc. Natl. Acad. Sci. USA 105 11364 11369 18687901 10.1073/pnas.0802076105 1:CAS:528:DC%2BD1cXhtVSgsrnF
19. M.E. Gegg J.M. Cooper K.Y. Chau M. Rojo A.H.V. Schapira J.W. Taanman 2010 Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy Hum. Mol. Genet. 19 4861 4870 20871098 10.1093/hmg/ddq419 1:CAS:528:DC%2BC3cXhsVyhsrzO
20. S. Geisler K.M. Holmstrom D. Skujat F.C. Fiesel O.C. Rothfuss P.J. Kahle W. Springer 2010 PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nat. Cell Biol. 12 119 131 20098416 10.1038/ncb2012 1:CAS:528:DC%2BC3cXhtlCqtbs%3D
21. E.E. Glater L.J. Megeath R.S. Stowers T.L. Schwarz 2006 Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent J. Cell Biol. 173 545 557 16717129 10.1083/jcb.200601067 1:CAS:528:DC%2BD28XltVaqsbc%3D (Pubitemid 43765201)
22. C.J. Gloeckner A. Schumacher K. Boldt M. Ueffing 2009 The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro J. Neurochem. 109 959 968 19302196 10.1111/j.1471-4159.2009.06024.x 1:CAS:528:DC%2BD1MXlsFylu7s%3D
23. J.C. Greene A.J. Whitworth I. Kuo L.A. Andrews M.B. Feany L.J. Pallanck 2003 Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants Proc. Natl. Acad. Sci. USA 100 4078 4083 12642658 10.1073/pnas.0737556100 1:CAS:528:DC%2BD3sXivFSqu70%3D (Pubitemid 36418160)
24. L.Y. Hao B.I. Giasson N.M. Bonini 2010 DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function Proc. Natl. Acad. Sci. USA 107 9747 9752 20457924 10.1073/pnas.0911175107 1:CAS:528:DC%2BC3cXntFGqtr4%3D
25. M.E. Haque K.J. Thomas C. D'souza S. Callaghan T. Kitada R.S. Slack P. Fraser M.R. Cookson A. Tandon D.S. Park 2008 Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP Proc. Natl. Acad. Sci. USA 105 1716 1721 18218782 10.1073/pnas.0705363105 1:CAS:528:DC%2BD1cXhvFamur0%3D (Pubitemid 351346580)
26. Haque, M.E.; Mount, M.P.; Safarpour, F.; Abdel-Messih, E.; Callaghan, S.; Mazerolle, C.; Kitada, T.; Slack, R.S.; Wallace, V.; Shen, J.; et al. (2012). Inactivation of Pink1 in vivo sensitizes dopamine producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive PD genes, Parkin or DJ-1. J. Biol. Chem. doi: 10.1074/jbc.M112.346437.
27. H.H. Hoepken S. Gispert B. Morales O. Wingerter D. Del Turco A. Mulsch R.L. Nussbaum K. Muller S. Drose U. Brandt, et al. 2007 Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6 Neurobiol. Dis. 25 401 411 17141510 10.1016/j.nbd.2006.10.007 1:CAS:528:DC%2BD2sXpvVKksQ%3D%3D (Pubitemid 46124020)
28. S. Hwang D. Kim G. Choi S.W. An Y.K. Hong Y.S. Suh M.J. Lee K.S. Cho 2010 Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila Mol. Cells 29 575 580 20496123 10.1007/s10059-010-0068-1 1:CAS:528:DC%2BC3cXptFKrtb4%3D
29. Y. Imai T. Kanao T. Sawada Y. Kobayashi Y. Moriwaki Y. Ishida K. Takeda H. Ichijo B.W. Lu R. Takahashi 2010 The Loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila PLoS Genet. 6 e1001229 21151955 10.1371/journal.pgen.1001229
30. I. Irrcher H. Aleyasin E.L. Seifert S.J. Hewitt S. Chhabra M. Phillips A.K. Lutz M.W.C. Rousseaux L. Bevilacqua A. Jahani-Asl, et al. 2010 Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics Hum. Mol. Genet. 19 3734 3746 20639397 10.1093/hmg/ddq288 1:CAS:528:DC%2BC3cXhtFCrsr3I
31. S.M. Jin M. Lazarou C.X. Wang L.A. Kane D.P. Narendra R.J. Youle 2010 Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL J. Cell Biol. 191 933 942 21115803 10.1083/jcb.201008084 1:CAS:528:DC%2BC3cXhsFCntLzO
32. B.H. Kang J. Plescia T. Dohi J. Rosa S.J. Doxsey D.C. Altieri 2007 Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network Cell 131 257 270 17956728 10.1016/j.cell.2007.08.028 1:CAS:528:DC%2BD2sXht1KqsbbN (Pubitemid 47576138)
33. D. Kim M.D. Nguyen M.M. Dobbin A. Fischer F. Sananbenesi J.T. Rodgers I. Delalle J.A. Baur G.C. Sui S.M. Armour, et al. 2007 SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J. 26 3169 3179 17581637 10.1038/sj.emboj.7601758 1:CAS:528:DC%2BD2sXnsFejt7k%3D (Pubitemid 47057498)
34. E.J. Kim J.H. Kho M.R. Kang S.J. Um 2007 Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity Mol. Cell 28 277 290 17964266 10.1016/j.molcel.2007.08.030 1:CAS:528:DC%2BD2sXhtlShtr7N (Pubitemid 47610741)
35. Y. Kim J. Park S. Kim S. Song S.K. Won S.H. Lee T. Kitada J.M. Kim J. Chung 2008 PINK1 controls mitochondrial localization of Parkin through direct phosphorylation Biochem. Biophys. Res. Commun. 377 975 980 18957282 10.1016/j.bbrc.2008.10.104 1:CAS:528:DC%2BD1cXhsVais7jP
36. J.E. Kim J.J. Chen Z.K. Lou 2008 DBC1 is a negative regulator of SIRT1 Nature 451 583 586 18235501 10.1038/nature06500 1:CAS:528:DC%2BD1cXhs1Sit78%3D (Pubitemid 351186264)
37. T. Kitada S. Asakawa N. Hattori H. Matsumine Y. Yamamura S. Minoshima M. Yokochi Y. Mizuno N. Shimizu 1998 Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 392 605 608 9560156 10.1038/33416 1:CAS:528:DyaK1cXis1Sqsrc%3D (Pubitemid 28207717)
38. T. Kitada A. Pisani D.R. Porter H. Yamaguchi A. Tscherter G. Martella P. Bonsi C. Zhang E.N. Pothos J. Shen 2007 Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice Proc. Natl. Acad. Sci. USA 104 11441 11666 17563363 10.1073/pnas.0702717104 1:CAS:528:DC%2BD2sXnvFOmsL4%3D (Pubitemid 47175159)
39. H. Koh H. Kim M.J. Kim J. Park H.J. Lee J. Chung 2012 Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila pten-induced kinase 1 (PINK1) null mutant J. Biol. Chem. 287 12750 12758 22378780 10.1074/jbc.M111. 337907 1:CAS:528:DC%2BC38XlsFCis7k%3D
40. G. Kops T.B. Dansen P.E. Polderman I. Saarloos K. W.A. Wirtz P.J. Coffer T.T. Huang J.L. Bos R.H. Medema B.M.T. Burgering 2002 Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress Nature 419 316 321 12239572 10.1038/nature01036 1:CAS:528:DC%2BD38XntFSgs7k%3D
41. A.E. Lang A.M. Lozano 1998 Parkinson's disease - first of two parts N. Engl. J. Med. 339 1044 1053 9761807 10.1056/NEJM199810083391506 1:STN:280:DyaK1cvisFKmsg%3D%3D (Pubitemid 28457867)
42. J.W. Langston P. Ballard J.W. Tetrud I. Irwin 1983 Chronic Parkinsonism in humans due to a product of meperidineanalog synthesis Science 219 979 980 6823561 10.1126/science.6823561 1:STN:280:DyaL3s7hvF2mtg%3D%3D (Pubitemid 13189531)
43. J.Y. Lee Y. Nagano J.P. Taylor K.L. Lim T.P. Yao 2010 Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy J. Cell Biol. 189 671 679 20457763 10.1083/jcb.201001039 1:CAS:528:DC%2BC3cXmslKktr4%3D
44. S. Liu T. Sawada S. Lee W. Yu G. Silverio P. Alapatt I. Millan A. Shen W. Saxton T. Kanao, et al. 2012 Parkinson's disease-sssociated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria PLoS Genet. 8 e1002537 22396657 10.1371/journal.pgen.1002537 1:CAS:528:DC%2BC38XjslOlt70%3D
45. N. Matsuda S. Sato K. Shiba K. Okatsu K. Saisho C.A. Gautier Y. Sou S. Saiki S. Kawajiri F. Sato, et al. 2010 PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy J. Cell Biol. 189 211 221 20404107 10.1083/jcb.200910140 1:CAS:528:DC%2BC3cXlt1Khu7c%3D
46. D. Narendra A. Tanaka D.F. Suen R.J. Youle 2008 Parkin is recruited selectively to impaired mitochondria and promotes their autophagy J. Cell Biol. 183 795 803 19029340 10.1083/jcb.200809125 1:CAS:528:DC%2BD1cXhsVOjtrjJ
47. D.P. Narendra S.M. Jin A. Tanaka D.F. Suen C.A. Gautier J. Shen M.R. Cookson R.J. Youle 2010 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin PLoS Biol. 8 e1000298 20126261 10.1371/journal.pbio.1000298
48. D.P. Narendra L.A. Kane D.N. Hauser I.M. Fearnley R.J. Youle 2010 p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy 6 1090 1106 20890124 10.4161/auto.6.8.13426 1:CAS:528:DC%2BC3cXhs1WltrjK
49. K. Okatsu K. Saisho M. Shimanuki K. Nakada H. Shitara Y. Sou M. Kimura S. Sato N. Hattori M. Komatsu, et al. 2010 p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria Genes Cells 15 887 900 20604804 1:CAS:528:DC%2BC3cXhtVCltbrP
50. C. Paisan-Ruiz S. Jain E.W. Evans W.P. Gilks J. Simon M. van der Brug A.L. de Munain S. Aparicio A.M. Gil N. Khan, et al. 2004 Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease Neuron 44 595 600 15541308 10.1016/j.neuron.2004.10.023 1:CAS:528:DC%2BD2cXhtVKhurjK (Pubitemid 39531224)
51. J. Park S.B. Lee S. Lee Y. Kim S. Song S. Kim E. Bae J. Kim M.H. Shong J.M. Kim, et al. 2006 Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature 441 1157 1161 16672980 10.1038/nature04788 1:CAS:528:DC%2BD28Xmtlaiu70%3D (Pubitemid 43990737)
52. J. Park G. Lee J. Chung 2009 The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process Biochem. Biophys. Res. Commun. 378 518 523 19056353 10.1016/j.bbrc.2008.11.086 1:CAS:528:DC%2BD1cXhsFClsrrF
53. J.A. Parker M. Arango S. Abderrahmane E. Lambert C. Tourette H. Catoire C. Neri 2005 Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons Nat. Genet. 37 349 350 15793589 10.1038/ng1534 1:CAS:528:DC%2BD2MXislCmu7w%3D
54. Y. Pesah T. Pham H. Burgess B. Middlebrooks P. Verstreken Y. Zhou M. Harding H. Bellen G. Mardon 2004 Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress Development 131 2183 2194 15073152 10.1242/dev.01095 1:CAS:528:DC%2BD2cXksFGju7g%3D (Pubitemid 38702049)
55. A. Petit T. Kawarai E. Paitel N. Sanjo M. Maj M. Scheid F.S. Chen Y.J. Gu H. Hasegawa S. Salehi-Rad, et al. 2005 Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations J. Biol. Chem. 280 34025 34032 16079129 10.1074/jbc.M505143200 1:CAS:528:DC%2BD2MXhtVKisbbL (Pubitemid 41443124)
56. H. Plun-Favreau K. Klupsch N. Moisoi S. Gandhi S. Kjaer D. Frith K. Harvey E. Deas R.J. Harvey N. McDonald, et al. 2007 The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 Nat. Cell Biol. 9 1243 1252 17906618 10.1038/ncb1644 1:CAS:528:DC%2BD2sXht1Cgu7fN (Pubitemid 350042356)
57. M.H. Polymeropoulos C. Lavedan E. Leroy S.E. Ide A. Dehejia A. Dutra B. Pike H. Root J. Rubenstein R. Boyer, et al. 1997 Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 2045 2047 9197268 10.1126/science.276.5321.2045 1:CAS:528:DyaK2sXkt1altr4%3D (Pubitemid 27443610)
58. A.C. Poole R.E. Thomas L.A. Andrews H.M. McBride A.J. Whitworth L.J. Pallanck 2008 The PINK1/Parkin pathway regulates mitochondrial morphology Proc. Natl. Acad. Sci. USA 105 1638 1643 18230723 10.1073/pnas.0709336105 1:CAS:528:DC%2BD1cXhvFWktbo%3D (Pubitemid 351346567)
59. J.W. Pridgeon J.A. Olzmann L.S. Chin L. Li 2007 PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1 PLoS Biol. 5 e172 17579517 10.1371/journal.pbio.0050172 (Pubitemid 47105341)
60. O. Puig M.T. Marr M. L. Ruhf R. Tjian 2003 Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway Genes Dev. 17 2006 2020 12893776 10.1101/gad.1098703 1:CAS:528:DC%2BD3sXms1Kntrw%3D (Pubitemid 36999327)
61. V. Sallinen J. Kolehmainen M. Priyadarshini G. Toleikyte Y.C. Chen P. Panula 2010 Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish Neurobiol. Dis. 40 93 101 20600915 10.1016/j.nbd.2010.06.001 1:CAS:528:DC%2BC3cXhtVGrt7vM
62. J. Sämann J. Hegermann E. von Gromoff S. Eimer R. Baumeister E. Schmidt 2009 Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth J. Biol. Chem. 284 16482 16491 19251702 10.1074/jbc.M808255200
63. A.H. Schapira J.M. Cooper D. Dexter J. B. Clark P. Jenner C.D. Marsden 1990 Mitochondrial complex I deficiency in Parkinson's disease J. Neurochem. 54 823 827 2154550 10.1111/j.1471-4159.1990.tb02325.x 1:CAS:528:DyaK3cXhsFKiur4%3D
64. G. Shi J.R. Lee D.A. Grimes L. Racacho D. Ye H. Yang O.A. Ross M. Farrer G.A. McQuibban D.E. Bulman 2011 Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease Hum. Mol. Genet. 20 1966 1974 21355049 10.1093/hmg/ddr077 1:CAS:528:DC%2BC3MXltFehsrY%3D
65. H. Shimura N. Hattori S. Kubo Y. Mizuno S. Asakawa S. Minoshima N. Shimizu K. Iwai T. Chiba K. Tanaka, et al. 2000 Familial Parkinson disease gene product, parkin, is a ubiquitinprotein ligase Nat. Genet. 25 302 305 10888878 10.1038/77060 1:STN:280:DC%2BD3czptF2nsw%3D%3D (Pubitemid 30437317)
66. L. Silvestri V. Caputo E. Bellacchio L. Atorino B. Dallapiccola E.M. Valente G. Casari 2005 Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism Hum. Mol. Genet. 14 3477 3492 16207731 10.1093/hmg/ddi377 1:CAS:528:DC%2BD2MXhtFymtbrE (Pubitemid 41672130)
67. L.S. Tain H. Mortiboys R.N. Tao E. Ziviani O. Bandmann A.J. Whitworth 2009 Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss Nat. Neurosci. 12 1129 1135 19684592 10.1038/nn.2372 1:CAS:528: DC%2BD1MXpvFCrt7c%3D
68. A. Tanaka M.M. Cleland S. Xu D.P. Narendra D.F. Suen M. Karbowski R.J. Youle 2010 Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin J. Cell Biol. 191 1367 1380 21173115 10.1083/jcb.201007013 1:CAS:528:DC%2BC3MXis1WjtQ%3D%3D
69. K.J. Thomas M.K. McCoy J. Blackinton A. Beilina M. van der Brug A. Sandebring D. Miller D. Maric A. Cedazo-Minguez M.R. Cookson 2011 DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy Hum. Mol. Genet. 20 40 50 20940149 10.1093/hmg/ddq430 1:CAS:528:DC%2BC3cXhsFGgsbnJ
70. E.M. Valente P.M. Abou-Sleiman V. Caputo M.M.K. Muqit K. Harvey S. Gispert Z. Ali D. Del Turco A.R. Bentivoglio D.G. Healy, et al. 2004 Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Science 304 1158 1160 15087508 10.1126/science.1096284 1:CAS:528:DC%2BD2cXktVyit7k%3D (Pubitemid 38661852)
71. A. van der Horst L.G.J. Tertoolen L.M.M. de Vries-Smits R.A. Frye R.H. Medema B.M.T. Burgering 2004 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) J. Biol. Chem. 279 28873 28879 15126506 10.1074/jbc.M401138200 (Pubitemid 38915754)
72. K. Venderova G. Kabbach E. Abdel-Messih Y. Zhang R.J. Parks Y. Imai S. Gehrke J. Ngsee M.J. Lavoie R.S. Slack, et al. 2009 Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease Hum. Mol. Genet. 18 4390 4404 19692353 10.1093/hmg/ddp394 1:CAS:528:DC%2BD1MXhtlWhu7bK
73. C. Vives-Bauza C. Zhou Y. Huang M. Cui R.L.A. de Vries J. Kim J. May M.A. Tocilescu W.C. Liu H.S. Ko, et al. 2010 PINK1-dependent recruitment of Parkin to mitochondria in mitophagy Proc. Natl. Acad. Sci. USA 107 378 383 19966284 10.1073/pnas.0911187107 1:CAS:528:DC%2BC3cXnsFCruw%3D%3D
74. X.N. Wang D. Winter G. Ashrafi J. Schlehe Y.L. Wong D. Selkoe S. Rice J. Steen M.J. LaVoie T.L. Schwarz 2011 PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility Cell 147 893 906 22078885 10.1016/j.cell.2011.10.018 1:CAS:528:DC%2BC3MXhsVKgsLbP
75. Y. Xi J. Ryan S. Noble M. Yu A.E. Yilbas M. Ekker 2010 Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function Eur. J. Neurosci. 31 623 633 20141529 10.1111/j.1460-9568.2010. 07091.x
76. Y.F. Yang S. Gehrke Y. Imai Z.N. Huang Y. Ouyang J.W. Wang L.C. Yang M.F. Beal H. Vogel B.W. Lu 2006 Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by Parkin Proc. Natl. Acad. Sci. USA 103 10793 10798 16818890 10.1073/pnas.0602493103 1:CAS:528:DC%2BD28XntFWmtr0%3D (Pubitemid 44078055)
77. Y.F. Yang Y.S. Ouyang L.C. Yang M.F. Bcal A. McQuibban H. Vogel B.W. Lu 2008 Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery Proc. Natl. Acad. Sci. USA 105 17585 17587 10.1073/pnas.0808806105 1:CAS:528:DC%2BD1cXhsVWnur%2FJ
78. J. Yun J.H. Cao M.W. Dodson I.E. Clark P. Kapahi R.B. Chowdhury M. Guo 2008 Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo J. Neurosci. 28 14500 14510 19118185 10.1523/JNEUROSCI.5141-08.2008 1:CAS:528:DC%2BD1MXnsF2nug%3D%3D
79. W.H. Zhao J.P. Kruse Y. Tang S.Y. Jung J. Qin W. Gu 2008 Negative regulation of the deacetylase SIRT1 by DBC1 Nature 451 587 590 18235502 10.1038/nature06515 1:CAS:528:DC%2BD1cXhs1Sit7w%3D (Pubitemid 351186268)
80. C. Zhou Y. Huang Y.F. Shao J. May D. Prou C. Perier W. Dauer E.A. Schon S. Przedborski 2008 The kinase domain of mitochondrial PINK1 faces the cytoplasm Proc. Natl. Acad. Sci. USA 105 12022 12027 18687899 10.1073/pnas.0802814105 1:CAS:528:DC%2BD1cXhtVChu73I
81. B.M. Zid A.N. Rogers S.D. Katewa M.A. Vargas M.C. Kolipinski T.A. Lu S. Benzer P. Kapahi 2009 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila Cell 139 149 160 19804760 10.1016/j.cell.2009.07.034 1:CAS:528:DC%2BD1MXhsVCjs7nO
82. E. Ziviani R.N. Tao A.J. Whitworth 2010 Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin Proc. Natl. Acad. Sci. USA 107 5018 5023 20194754 10.1073/pnas.0913485107 1:CAS:528: DC%2BC3cXjvFGnt7k%3D