Silent information regulator 2 (Sir2) and forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12750-12758

  Koh, Hyongjong ^a   Kim, Hyunjin ^a   Kim, Min Ju ^a   Park, Jeehye ^b   Lee, Hye Jeong ^a   Chung, Jongkyeong ^b  

^a Dong A University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DELETERIOUS EFFECTS; DOPAMINERGIC NEURONS; DOWNSTREAM TARGET; ECTOPIC EXPRESSIONS; FORKHEAD BOX O; GENETIC ANALYSIS; GENETIC SCREENING; MITOCHONDRIAL DEFECTS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; NULL MUTANT; OVER-EXPRESSION; PARKINSON DISEASE;

AMINO ACIDS; DEFECTS; DISEASES; ENZYMES; GENES; NEURONS;

MITOCHONDRIA;

PHOSPHOTRANSFERASE; PINK1 PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; DROSOPHILA; FOXO GENE; GENE; GENE DELETION; GENE TARGETING; GENETIC ANALYSIS; LOSS OF FUNCTION MUTATION; MALE; NEUROPROTECTION; NONHUMAN; PARKIN GENE; PINK1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIR2 GENE; SOD2 GENE; THOR GENE;

ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DROSOPHILA; DROSOPHILA PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HISTONE DEACETYLASES; MITOCHONDRIAL DISEASES; PARKINSONIAN DISORDERS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SIRTUINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84859759299     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.337907     Document Type: Article

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