Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin

Journal of Antibiotics

Volumn 65, Issue 7, 2012, Pages 341-348

  Gómez, Cristina ^a   Olano, Carlos ^a   Palomino Schätzlein, Martina ^b   Pineda Lucena, Antonio ^b   Carbajo, Rodrigo J ^b   Brãa, Alfredo F ^a   Méndez, Carmen ^a   Salas, José A ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Laboratorio de Bioquiacute mica Estructural   (Spain)

Author keywords

cytochrome P450; nonribosomal peptide; polyketide; silenced pathway; streptolydigin; Streptomyces; tetramic acid

Indexed keywords

3 METHYLASPARTATE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BENZOIC ACID DERIVATIVE; CHRISTOLANE A; CHRISTOLANE B; CHRISTOLANE C; CYTOCHROME P450; CYTOTOXIC AGENT; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE; SLGL PROTEIN; SLGN1 PROTEIN; SLGN2 PROTEIN; SLGO2 PROTEIN; STREPTOLYDIGIN; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE INACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES LYDICUS NRRL 2433;

AMINOGLYCOSIDES; AMINOISOBUTYRIC ACIDS; ANTI-BACTERIAL AGENTS; GENETIC ENGINEERING; MUTATION; PARA-AMINOBENZOATES; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES LYDICUS;

EID: 84864427303     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.37     Document Type: Article

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