Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis

Biochemistry

Volumn 44, Issue 8, 2005, Pages 2770-2780

  Garneau, Sylvie ^a   Dorrestein, Pieter C ^b   Kelleher, Neil L ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; DNA; ENZYMES; ESTERS; FOURIER TRANSFORMS; IONIZATION; MASS SPECTROMETRY; OXIDATION; PROTEINS;

FOURIER TRANSFORM MASS SPECTROMETRY; PEPTIDYL CARRIER PROTEIN (PCP); PYRROLYL PHARMACOPHORES; THIOESTERS;

BIOCHEMISTRY;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CARRIER PROTEIN; CLOROBIOCIN; COUMAMYCIN A1; DNA TOPOISOMERASE (ATP HYDROLYSING); FLAVOPROTEIN; PROLINE; PYRROLE; THIOESTER; UNCLASSIFIED DRUG;

ADENYLATION; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BINDING SITE; COMPLEX FORMATION; ELECTRON; ELECTROSPRAY; ENZYME SPECIFICITY; FOURIER TRANSFORM MASS SPECTROMETRY; NONHUMAN; OXIDATION; PHARMACOPHORE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINOCOUMARINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; DNA PRIMERS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NOVOBIOCIN; POLYMERASE CHAIN REACTION; PYRROLES; RESTRICTION MAPPING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 14344261742     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0476329     Document Type: Article

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