Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin

Biochemical Journal

Volumn 386, Issue 1, 2005, Pages 57-62

  Mendes, Marta V ^a   Antón, Nuria ^a   Martín, Juan F ^a,b   Aparicio, Jesús F ^a,b  

^a Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^b UNIVERSITY OF LEÓN   (Spain)

Author keywords

Cytochrome P450 mono oxygenase; Epoxidase; Pimaricin; Polyene; Polyketide synthase

Indexed keywords

CATALYSIS; CHARACTERIZATION; ENZYME KINETICS; ENZYMES; ESCHERICHIA COLI; OXIDATION; PROTEINS;

EPOXIDATION; KINETIC ANALYSIS; OXIDATIVE MODIFICATION; POLYENE MACROLIDE;

BIOSYNTHESIS;

CYTOCHROME P450; MACROLIDE; NATAMYCIN; POLYKETIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNSPECIFIC MONOOXYGENASE;

ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL GENE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME SPECIFICITY; EPOXIDATION; ESCHERICHIA COLI; IMMUNOBLOTTING; NONHUMAN; PH; PIMD GENE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES NATALENSIS;

BACTERIAL PROTEINS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; HYDROGEN-ION CONCENTRATION; KINETICS; MACROLIDES; NADP; NATAMYCIN; RECOMBINANT FUSION PROTEINS; STREPTOMYCES; TEMPERATURE;

ESCHERICHIA COLI; STREPTOMYCES NATALENSIS;

EID: 14244251991     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040490     Document Type: Article

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