New insights in dihydropyrimidine dehydrogenase deficiency: A pivotal role for β-aminoisobutyric acid?

Biochemical Journal

Volumn 379, Issue 1, 2004, Pages 119-124

  Van Kuilenburg, André B P ^a,c   Stroomer, Alida E M ^a   Van Lenthe, Henk ^a   Abeling, Nico G G M ^a   Van Gennip, Albert H ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

alanine; aminoisobutyrate; aminobutyric acid; Dihydropyrimidine dehydrogenase; Enantiomer; Valine

Indexed keywords

CATALYSIS; METABOLISM; MOLECULAR ORIENTATION; PATHOLOGY; PLASMAS; STEREOCHEMISTRY;

CEREBROSPINAL; CLINICAL ABNORMALITY; PYRIMIDINE; URINE;

ENZYME KINETICS;

3 AMINO 2 METHYLPROPIONIC ACID; BETA ALANINE; CARNOSINE; DIHYDROPYRIMIDINE DEHYDROGENASE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD LEVEL; CEREBROSPINAL FLUID; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; HOMEOSTASIS; HUMAN; INFANT; KIDNEY CONCENTRATING CAPACITY; MALE; NEWBORN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM;

AMINOISOBUTYRIC ACIDS; BETA-ALANINE; BRAIN DISEASES, METABOLIC, INBORN; DIHYDROURACIL DEHYDROGENASE (NADP); FLUOROURACIL; HOMEOSTASIS; HUMANS; METABOLIC DETOXICATION, DRUG; NEUROTRANSMITTER AGENTS; PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS; STEREOISOMERISM; THYMINE; URACIL; VALINE;

EID: 1842833383     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031463     Document Type: Article

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