Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and v

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 10-21

  Marques, Emerson F ^a   Bueno, Mauro A ^a   Duarte, Patrícia D ^a   Silva, Larissa R S P ^a   Martinelli, Ariani M ^a   Dos Santos, Caio Y ^a   Severino, Richele P ^b   Brömme, Dieter ^c   Vieira, Paulo C ^a   Corrêa, Arlene G ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cathepsins V and L; Quinolinone and acridone alkaloids; Synthetic inhibitors

Indexed keywords

2 ( 4 BUTOXYPHENYL)QUINOLIN 4 (1H) ONE; 2 ( 4 BUTYLPHENYL)QUINOLIN 4 (1H) ONE; 2 ( 4 ETHYLPHENYL)QUINOLIN 4 (1H) ONE; 2 ( 4 FLUOROPHENY)QUINOLIN 4 (1H) ONE; 2 ( 4 TOLYLQUINOLIN) 4 (1H) ONE; 2 (BUT 3 ENYL)QUINOLIN 4 (1H) ONE; 2 (FURAN 2 YL)QUINOLIN 4 (1H) ONE; 2 PHENYLQUINOLIN 4 (1H) ONE; 2 UNDECYLQUINOLIN 4 (1H) ONE; ACETOPHENONE; ACETOPHENONE DERIVATIVE; ACRIDONE DERIVATIVE; ANTHRANILIC ACID DERIVATIVE; CATHEPSIN INHIBITOR; CATHEPSIN L; CATHEPSIN V; CYSTEINE PROTEINASE INHIBITOR; N ( 2 ACETYLPHENYL) 4 BUTOXYBENZAMIDE; N ( 2 ACETYLPHENYL) 4 BUTYLBENZAMIDE; N ( 2 ACETYLPHENYL) 4 ETHYLBENZAMIDE; N ( 2 ACETYLPHENYL) 4 FLUORO 3 (TRIFLUOROMETHYL)BENZAMIDE; N ( 2 ACETYLPHENYL) 4 FLUOROBENZAMIDE; N ( 2 ACETYLPHENYL) 4 HEXYLBENZAMIDE; N ( 2 ACETYLPHENYL) 4 METHYLBENZAMIDE; N ( 2 ACETYLPHENYL)BENZAMIDE; N ( 2 ACETYLPHENYL)FURAN 2 CARBOXAMIDE; N ( 2 ACETYLPHENYL)PENT 4 ENAMIDE; N ( 2 ACETYLPHENYL)UNDECANAMIDE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME KINETICS; HUMAN; IC 50; PROTEIN TARGETING;

4-QUINOLONES; ACRIDINES; CATHEPSIN L; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; HUMANS; PROTEASE INHIBITORS;

EID: 84864408659     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.002     Document Type: Article

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