Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 1, 2011, Pages 396-400

  Frizler, Maxim ^a   Lohr, Friederike ^a   Furtmann, Norbert ^a   Kläs, Julia ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CATHEPSIN B; CATHEPSIN K INHIBITOR; CATHEPSIN L; CATHEPSIN S; N (4 CYANOPHENYLCARBAMOYL) LEUCINE TERT BUTYL ESTER; N [(4 ACETOXYAMIDINO)PHENYLCARBAMOYL] LEUCINE TERT BUTYL ESTER; N [4 (5 METHYL 1,2,4 OXADIAZOL 3 YL)PHENYLCARBAMOYL] LEUCINE; N [4 (5 METHYL 1,2,4 OXADIAZOL 3 YL)PHENYLCARBAMOYL] LEUCYLMETHYLAZAALANINE NITRILE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DISSOCIATION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; METHYLATION; PROCESS OPTIMIZATION; STRUCTURE ANALYSIS;

AZA COMPOUNDS; CATHEPSIN K; DIPEPTIDES; KINETICS; NITRILES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78651072739     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101272p     Document Type: Article

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