Acridone alkaloids as potent inhibitors of cathepsin v

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1477-1481

  Severino, Richele P ^a,b   Guido, Rafael V C ^c   Marques, Emerson F ^a   Brömme, Dieter ^d   Da Silva, M Fátima Das G F ^a   Fernandes, João B ^a   Andricopulo, Adriano D ^c   Vieira, Paulo C ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Acridone alkaloids; Cathepsin V; Enzyme inhibitors; Natural products

Indexed keywords

1,3,5 TRIHYDROXY 2,8 BIS(3 METHYLBUT 2 ENYL) 10 METHYL 9 ACRIDONE; 1,3,5 TRIHYDROXY 4 METHOXY 10 METHYL 2,8 BIS(3 METHYLBUT 2 ENYL)ACRIDIN 9(10H) ONE; 2,3 DIHYDRO 4,9 DIHYDROXY 2 (2 HYDROXYPROPAN 2 YL) 11 METHOXY 10 METHYLFURO[3,2 B]ACRIDIN 5(10H) ONE; 3,4 DIHYDRO 3,5,8 TRIHYDROXY 6 METHOXY 2,2,7 TRIMETHYL 2H PYRANO[2,3 A]ACRIDIN 12(7H) ONE; 5 HYDROXYNORACRONYCINE; ACRIDONE DERIVATIVE; ALKALOID DERIVATIVE; CATHEPSIN V; CITIBRASINE; CITRUSININE 1; CITRUSININE 2; ENZYME INHIBITOR; GLYCOCITRINE 1; GLYCOCITRINE 4; PYRANOFOLINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; MOLECULAR MODEL; RUTACEAE; STRUCTURE ACTIVITY RELATION; SWINGLEA GLUTINOSA;

ACRIDINES; ALKALOIDS; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

RUTACEAE; SWINGLEA GLUTINOSA;

EID: 79951556503     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.056     Document Type: Article

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