2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 1969-1975

  Stefańska, Barbara ^a   Bontemps Gracz, Maria M ^a   Antonini, Ippolito ^b   Martelli, Sante ^b   Arciemiuk, Małgorzata ^a   Piwkowska, Agnieszka ^a   Rogacka, Dorota ^a   Borowski, Edward ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Acridine analogs; Antitumor compounds; Cytotoxic activity; Multidrug resistance

Indexed keywords

2 (2 MORPHOLINOETHYL) 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 2 (2 PIPERIDINOETHYL) 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 2 [2 (DIMETHYLAMINO)ETHYL] 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 2 [3 (DIMETHYLAMINO)ETHYL] 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 2 [3 (DIMETHYLAMINO)PROPYL] 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 6 CHLORO 2 [2 (DIMETHYLAMINO)ETHYL] 2,7 DIHYDRO 3H DIBENZO[DE,H]CINNOLINE 3,7 DIONE; 6 CHLORO 2 [2 (DIMETHYLAMINO)PROPYL) 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 6 CHLORO 2,7 DIHYDRO 3H PYRIDAZINO[5,4,3 KL]ACRIDIN 3 ONE; 9 OXO 9,10 DIHYDROACRIDINE 1 CARBOXYLATE; ACRIDINE DERIVATIVE; CYTOTOXIC AGENT; DOXORUBICIN; HYDRAZINE DERIVATIVE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; PHOSPHORUS DERIVATIVE; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MULTIDRUG RESISTANCE; MYELOID LEUKEMIA; NONHUMAN; PROMYELOCYTIC LEUKEMIA;

EID: 13844305773     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.023     Document Type: Article

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