Structure-Activity Relationships of N-Acyl Pyrroloquinolone PDE-5 Inhibitors

Journal of Medicinal Chemistry

Volumn 47, Issue 3, 2004, Pages 656-662

  Lanter, James C ^a   Sui, Zhihua ^a   Macielag, Mark J ^a   Fiordeliso, James J ^a   Jiang, Weiqin ^a   Qiu, Yuhong ^a   Bhattacharjee, Sheela ^a   Kraft, Patricia ^a   John, T Mathew ^a   Haynes Johnson, Donna ^a   Craig, Elizabeth ^a   Clancy, Joanna ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACYLPYRROLOQUINOLONE; PHOSPHODIESTERASE V INHIBITOR; QUINOLONE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ERECTILE DYSFUNCTION; MALE; NONHUMAN; PENIS ERECTION; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; DIOXOLES; DOGS; INJECTIONS, INTRAVENOUS; MALE; PENILE ERECTION; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRROLES; QUINOLONES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9144222568     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020521s     Document Type: Article

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