Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3072-3082

  Thi Mai, Huong Doan ^a   Gaslonde, Thomas ^a   Michel, Sylvie ^a   Tillequin, François ^a   Koch, Michel ^a   Bongui, Jean Bernard ^b   Elomri, Abdelhakim ^b   Seguin, Elisabeth ^b   Pfeiffer, Bruno ^c   Renard, Pierre ^c   David Cordonnier, Marie Hélène ^d   Laine, William ^d   Bailly, Christian ^d   Kraus Berthier, Laurence ^e   Léonce, Stéphane ^e   Hickman, John A ^e   Pierré, Alain ^e  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Lab Pharmacog Univ R H N   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d INSERM   (France)

^e INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXY 2 ACYLOXY 6 METHYOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE DERIVATIVE; 1 METHOXY 2 ACETOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE; 1,2 DIACETOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE; 1,2 DIACYLOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3 14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE DERIVATIVE; 2 ACETOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 1,7 DIONE; 2 ACETOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE; 2 DI O CARBONYL 1,2 DIHYDROXY 3,3,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE; 2 PROPIOXY 6 METHOXY 1,1,14 TRIMETHYL 1,2,3,14 TETRAHYDRO 7H BENZO[B]PYRANO[3,2 H]ACRIDINE 1,7 DIONE; 3 BROMO 2 NAPHTHOIC ACID; 4 AMINO 2,2 DIMETHYL 2H CHROMENE; 6 DEMETHOXYACRONINE DERIVATIVE; ACRONINE; ANTINEOPLASTIC AGENT; BENZO[B]PYRANO[3,2 H]ACRIDIN 7 ONE DERIVATIVE; CHROMENE DERIVATIVE; ESTER; GENOMIC DNA; GUANINE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CYCLIZATION; CYTOTOXICITY; DNA ADDUCT; DNA ALKYLATION; DNA HELIX; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; MOUSE; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; TRANSESTERIFICATION;

ACRIDINES; ACRONINE; ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL DIVISION; DNA; DNA ADDUCTS; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037698962     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030790y     Document Type: Article

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