Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4210-4214

  Verissimo, Edite ^a,b   Berry, Neil ^b   Gibbons, Peter ^b   Cristiano, M Lurdes S ^a   Rosenthal, Philip J ^c   Gut, Jiri ^c   Ward, Stephen A ^d   O'Neill, Paul M ^b  

^a UNIVERSITY OF ALGARVE   (Portugal)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Cysteine protease; Falcipain 2; Malaria; Peptidomimetic; Plasmodium falciparum

Indexed keywords

2 PYRIDONE DERIVATIVE; CHLOROQUINE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 47149098176     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.068     Document Type: Article

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