Plant-derived antimalarial agents: New leads and efficient phytomedicines. part II. non-alkaloidal natural products

Molecules

Volumn 14, Issue 8, 2009, Pages 3037-3072

  Batista, Ronan ^a   De Jesus Silva Júnior, Ademir ^a   De Oliveira, Alaíde Braga ^b  

^a UNIVERSIDADE ESTADUAL DO SUDOESTE DA BAHIA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Antiplasmodial activity; Malaria; Non alkaloidal natural products; Plasmodium

Indexed keywords

ANTIMALARIAL AGENT; BIOLOGICAL PRODUCT;

ANIMAL; CHEMISTRY; DRUG EFFECT; HUMAN; MALARIA; PLANT; PLASMODIUM FALCIPARUM; REVIEW;

ANIMALS; ANTIMALARIALS; BIOLOGICAL PRODUCTS; HUMANS; MALARIA; PLANTS; PLASMODIUM FALCIPARUM;

EID: 69549135067     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14083037     Document Type: Review

References (104)

1. Greenwood, B.M.; Bojang, K.; Whitty, C.J.; Targett, G.A. Malaria. Lancet 2005, 365, 1487-1498.
2. Winter, R.W.; Kelly, J.X.; Smilkstein, M.J.; Dodean, R.; Bagby, G.C.; Rathbun R.K.; Levin, J.I.; Hinrichs, D.; Riscoe, M.K. Evaluation and lead optimization of anti-malarial acridones. Exp. Parasitol. 2006, 114, 47-56.
3. Sachs, J.; Malaney, P. The economic and social burden of malaria. Nature 2002, 415, 680-685.
4. WHO. World Malaria Report. World Health Organization: Geneva, Switzerland, 2008. http://apps.who.int/malaria/wmr2008/.
5. Fidock, D.A.; Rosenthal, P.J.; Croft, S.L.; Brun, R.; Nwaka, S. Antimalarial drug discovery: efficacy models for compound screening. Nat. Rev. Drug Discov. 2004, 3, 509-520.
6. Deprez-Poulain, R.; Melnyk, P. 1,4-Bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets. Comb. Chem. High Throughput Screen. 2005, 8, 39-48.
7. Jones, M.K.; Good, M.F. Malaria parasites up close. Nat. Med. 2006, 12, 170-171.
8. Saxena, S.; Pant, N.; Jain, D.C.; Bhakuni, R.S. Antimalarial agents from plant sources. Curr. Sci. 2003, 85, 1314-1329.
9. Viegas Júnior, C.; Bolzani, V.S.; Barreiro, E.J. Os produtos naturais e a química medicinal moderna. Quím. Nova 2006, 29, 326-337.
10. Taylor, W.R.; White, N.J. Antimalarial drug toxicity: a review. Drug Saf. 2004, 27, 25-61.
11. Jambou, R.; Legrand, E.; Niang, M.; Khim, N.; Lim, P.; Volney, B.; Ekala, M.T.; Bouchier, C.; Esterre, P.; Fandeur, T.; Mercereau-Puijalon, O. Resistance of Plasmodium falciparum field isolates to in vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 2005, 366, 1960-1963.
12. Wichmann, O.; Muhlen, M.; Grub, H.; Mockenhaupt, F.P.; Suttorp, N.; Jelinek, T. Malarone treatment failure not associated with previously described mutations in the cytochrome b gene. Malaria J. 2004, 3, 1-3.
13. Newman, D.J.; Cragg, G.M.; Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 2003, 66, 1022-1037.
14. Ziegler, H.L.; Staerk, D.; Christensen, J.; Hviid, L.; Hagerstrand, H.; Jaroszewski, J.W. In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into the erythrocyte membrane. Antimicrob. Agents Chemother. 2002, 46, 1441-1446.
15. Kalauni, S.K.; Awale, S.; Tezuka, Y.; Banskota, A.H.; Linn, T.Z.; Asih, P.B.; Syafruddin, D.; Kadota, S. Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship. Biol. Pharm. Bull. 2006, 29, 1050-1052.
16. Portet, B.; Fabre, N.; Roumy, V.; Gornitzka, H.; Bourdy, G.; Chevalley, S.; Sauvain, M.; Valentin, A.; Moulis, C. Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense. Phytochemistry 2007, 68, 1312-1320.
17. Frederich, M.; Tits, M.; Angenot, L. Potential antimalarial activity of indole alkaloids. Trans. R. Soc. Trop. Med. Hyg. 2008, 102, 11-19.
18. Kaur, K.; Jain, M.; Kaur, T.; Jain, R. Antimalarials from nature. Bioorg. Med. Chem. 2009, 17, 3229-3256.
19. Oliveira, A.B.; Dolabela, M.F.; Braga, F.C.; Jácome, R.L.R.P.; Varotti, F.P.; Póvoa, M.M. Plantderived antimalarial agents: new leads and efficient phytomedicines. Part I. Alkaloids. Ann. Braz. Acad. Sci. 2009, in press.
20. Basco, L.; Mitaku, S.; Skaltsounis, A.L.; Ravelomanantsoa, N.; Tillequin, R.; Koch, M.; Le Bras, J. In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum. Antimicrob. Agents Chemother. 1994, 38, 1169-1171.
21. Dolabela, M.F.; Oliveira, S.G.; Nascimento, J.M.; Peres, J.M.; Wagner, H.; Póvoa, M.M.; Oliveira, A.B. In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. Phytomedicine 2008, 15, 367-372.
22. Muriithi, M.W.; Abraham, W.R.; Addae-Kyereme, J.; Scowen, I.; Croft, S.L.; Gitu, P.M.; Kendrick, H.; Njagi, E.N.M.; Wright, C.W. Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normeliopicine. J. Nat. Prod. 2002, 65, 956-959.
23. Pillay, P.; Maharaj, V.J.; Smith, P.J. Investigation South African plants as a source of new antimalarial drugs. J. Ethnopharmacol. 2008, 119, 438-454.
24. Mariath, I.R.; Falcão, H.S.; Barbosa-Filho, J.M.; Sousa, L.C.F.; Tomaz, A.C.A.; Batista, L.M.; Diniz, M.F.M.F.; Athayde-Filho, P.F.; Tavares, J.F.; Silva, M.S.; Cunha, E.V.L. Plants of the American continent with antimalarial activity. Braz. J. Pharmacogn. 2009, 19, 158-192.
25. Zirihi, G.N.; Mambu, L.; Guédé-Guina, F.; Bodo, B.; Grellier, P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. J. Ethnopharmacol. 2005, 98, 281-285.
26. Koch, A.; Tamez, P.; Pezzuto, J.; Soejarto, D. Evaluation of plants used for antimalarial treatment by the Maasai of Kenya. J. Ethnopharmacol. 2005, 101, 95-99.
27. Mbatchi, S.F.; Mbatchi, B.; Banzouzi, J.T.; Bansimba, T.; Nsonde Ntandou, G.F.; Ouamba, J.M.; Berry, A.; Benoit-Vical, F. In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine. J. Ethnopharmacol. 2006, 104, 168-174.
28. Menan, H.; Banzouzi, J.T.; Hocquette, A.; Pelissier, Y.; Blache, Y.; Kone, M.; Mallie, M.; Assi, L.A.; Valentin, A. Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria. J. Ethnopharmacol. 2006, 105, 131-136.
29. Kvist, L.P.; Christensen, S.B.; Rasmussen, H.B.; Mejia, K.; Gonzalez, A. Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. J. Ethnopharmacol. 2006, 106, 390-402.
30. Hout, S.; Chea, A.; Bun, S.S.; Elias, R.; Gasquet, M.; Timon-David, P.; Balansard, G.; Azas, N. Screening of selected indigenous plants of Cambodia for antiplasmodial activity. J. Ethnopharmacol. 2006, 107, 12-18.
31. Nguyen-Pouplin, J.; Tran, H.; Phan, T.A.; Dolecek, C.; Farrar, J.; Tran, T.H.; Caron, P.; Bodo, B.; Grellier, P. Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam. J. Ethnopharmacol. 2007, 109, 417-427.
32. de Mesquita, M.L.; Grellier, P.; Mambu, L.; de Paula, J.E.; Espindola, L.S. In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies. J. Ethnopharmacol. 2007, 110, 165-170.
33. Muregi, F.W.; Ishih, A.; Miyase, T.; Suzuki, T.; Kino, H.; Amano, T.; Mkoji, G.M.; Terada, M. Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice. J. Ethnopharmacol. 2007, 111, 190-195. (Pubitemid 46482893)
34. Osorio, E.; Arango, G.J.; Jimenez, N.; Alzate, F.; Ruiz, G.; Gutierrez, D.; Paco, M.A.; Gimenez, A.; Robledo, S. Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. J. Ethnopharmacol. 2007, 111, 630-635.
35. Roumy, V.; Garcia-Pizango, G.; Gutierrez-Choquevilca, A.L.; Ruiz, L.; Jullian, V.; Winterton, P.; Fabre, N.; Moulis, C.; Valentin, A. Amazonian plants from Peru used by Quechua and Mestizo to treat malaria with evaluation of their activity. J. Ethnopharmacol. 2007, 112, 482-489.
36. Muthaura, C.N.; Rukunga, G.M.; Chhabra, S.C.; Omar, S.A.; Guantai, A.N.; Gathirwa, J.W.; Tolo, F.M.; Mwitari, P.G.; Keter, L.K.; Kirira, P.G.; Kimani, C.W.; Mungai, G.M.; Njagi, E.N. Antimalarial activity of some plants traditionally used in treatment of malaria in Kwale district of Kenya. J. Ethnopharmacol. 2007, 112, 545-551.
37. Soh, P.N.; Benoit-Vical, F. Are West African plants a source of future antimalarial drugs? J. Ethnopharmacol. 2007, 114, 130-140.
38. Mesia, G.K.; Tona, G.L.; Nanga, T.H.; Cimanga, R.K.; Apers, S.; Cos, P.; Maes, L.; Pieters, L.; Vlietinck, A.J. Antiprotozoal and cytotoxic screening of 45 plant extracts from Democratic Republic of Congo. J. Ethnopharmacol. 2008, 115, 409-415.
39. Benoit-Vical, F.; Soh, P.N.; Salery, M.; Harguem, L.; Poupat, C.; Nongonierma, R. Evaluation of Senegalese plants used in malaria treatment: focus on Chrozophora senegalensis. J. Ethnopharmacol. 2008, 116, 43-48.
40. Kaou, A.M.; Mahiou-Leddet, V.; Hutter, S.; Ainouddine, S.; Hassani, S.; Yahaya, I.; Azas, N.; Ollivier, E. Antimalarial activity of crude extracts from nine African medicinal plants. J. Ethnopharmacol. 2008, 116, 74-83.
41. Bero, J.; Ganfon, H.; Jonville, M.C.; Frederich, M.; Gbaguidi, F.; DeMol, P.; Moudachirou, M.; Quetin-Leclercq, J. In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria. J. Ethnopharmacol. 2009, 122, 439-444.
42. Celine, V.; Adriana, P.; Eric, D.; Joaquina, A.C.; Yannick, E.; Augusto, L.F.; Rosario, R.; Dionicia, G.; Michel, S.; Denis, C.; Genevieve, B. Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts. J. Ethnopharmacol. 2009, 123, 413-422.
43. Wright, C.W. Plant derived antimalarials agents: new leads and challenges. Phytochem. Rev. 2005, 4, 55-61.
44. Hilou, A.; Nacoulma, O.G.; Guiguemde, T.R. In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice. J. Ethnopharmacol. 2006, 103, 236-240.
45. Boyom, F.F.; Kemgne, E.M.; Tepongning, R.; Mbacham, W.F.; Tsamo, E.; Zollo, P.H.A.; Gut, J.; Rosenthal, P.J. Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. J. Ethnopharmacol. 2009, 123, 483-488.
46. Jonville, M.C.; Kodja, H.; Humeau, L.; Fournel, J.; De Mol, P.; Cao, M.; Angenot, L.; Frederich, M. Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity. J. Ethnopharmacol. 2008, 120, 382-386.
47. Esmaeili, S.; Naghibi, F.; Mosaddegh, M.; Sahranavard, S.; Ghafari, S.; Abdullah, N.R. Screening of antiplasmodial properties among some traditionally used Iranian plants. J. Ethnopharmacol. 2009, 121, 400-404.
48. Okokon, J.E.; Antia, B.S.; Igboasoiyi, A.C.; Essien, E.E.; Mbagwu, H.O. Evaluation of antiplasmodial activity of ethanolic seed extract of Picralima nitida. J Ethnopharmacol. 2007, 111, 464-467.
49. Abdel-Sattar, E.; Harraz, F.M.; Al-Ansari, S.M.; El-Mekkawy, S.; Ichino, C.; Kiyohara, H.; Otoguro, K.; Omura, S.; Yamada, H. Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia. Nat. Med. (Tokyo) 2009, 63, 232-239.
50. Tona, L., Cimanga, R.K., Mesia K., Musuamba, C.T., De Bruyne, T., Apers, S., Hernans, N., Van Miert, S., Pieters, L., Totté, J., Vlietinck, A.J. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. J. Ethnopharmacol. 2004, 93, 27-32.
51. (A)- benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa. J. Ethnopharmacol. 2007, 110, 451-457.
52. Okokon, J.E.; Nwafor, P.A. Antiplasmodial activity of root extract and fractions of Croton zambesicus. J. Ethnopharmacol. 2009, 121, 74-78.
53. Lenta, B.N.; Vonthron-Senecheau, C.; Soh, R.F.; Tantangmo, F.; Ngouela, S.; Kaiser, M.; Tsamo, E.; Anton, R.; Weniger, B. In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants. J. Ethnopharmacol. 2007, 111, 8-12. (Pubitemid 46482889)
54. Waako, P.J.; Gumede, B.; Smith, P.; Folb, P.I. The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. J. Ethnopharmacol. 2005, 99, 137-143.
55. Khaomek, P.; Ichino, C.; Ishiyama, A.; Sekiguchi, H.; Namatame, M.; Ruangrungsi, N.; Saifah, E.; Kiyohara, H.; Otoguro, K.; Omura, S.; Yamada, H. In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca. J. Nat. Med. 2008, 62, 217-220.
56. Okokon, J.E.; Udokpoh, A.E.; Antia, B.S. Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit. J. Ethnopharmacol. 2007, 111, 537-540.
57. Iwalewa, E.O.; Omisore, N.O.; Adewunmi, C.O.; Gbolade, A.A.; Ademowo, O.G. Anti-protozoan activities of Harungana madagascariensis stem bark extract on trichomonads and malaria. J. Ethnopharmacol. 2008, 117, 507-511.
58. Phillipe, G.; Angenot, L.; De Mol, P.; Goffin, E.; Hayette, M.P.; Tits, M.; Frédérich, M. In vitro screening of some Strychnos species for antiplasmodial activity. J. Ethnopharmacol. 2005, 97, 535-539.
59. Okokon, J.E.; Ita, B.N.; Udokpoh, A.E. Antiplasmodial activity of Cylicodiscus gabunensis. J. Ethnopharmacol. 2006, 107, 175-178.
60. Abosl, A.O.; Mbukwa, E.; Majinda, R.R.; Raserok, B.H.; Yenesew, A.; Midiwo, J.O.; Akala, H.; Liyala, P.; Waters, N.C. Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity. Br. J. Biomed. Sci. 2006, 63, 129-133.
61. Lategan, C.A.; Campbell, W.E.; Seaman, T.; Smith, P.J. The bioactivity of novel furanoterpenoids isolated from Siphonochilus aethiopicus. J. Ethnopharmacol. 2009, 121, 92-97.
62. Pedersen, M.M.; Chukwujekwu, J.C.; Lategan, C.A.; Staden, J.; Smith, P.J.; Staerk, D. Antimalarial sesquiterpene lactones from Distephanus angulifolius. Phytochemistry 2009, 70, 601-607.
63. Efange, S.M.; Brun, R.; Wittlin, S.; Connolly, J.D.; Hoye, T.R.; McAkam, T.; Makolo, F.L.; Mbah, J.A.; Nelson, D.P.; Nyongbela, K.D.; Wirmum, C.K. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. J. Nat Prod. 2009, 72, 280-283.
64. Murata, T.; Miyase, T.; Muregi, F.W.; Naoshima-Ishibashi, Y.; Umehara, K.; Warashina, T.; Kanou, S.; Mkoji, G.M.; Terada, M.; Ishih, A. Antiplasmodial triterpenoids from Ekebergia capensis. J. Nat. Prod. 2008, 71, 167-174.
65. Jonville, M.C.; Capel, M.; Frederich, M.; Angenot, Luc; Dive, G.; Faure, R.; Azas, N.; Ollivier, E. Fagraldehyde, a secoiridoid isolated from Fagraea fragrans. J. Nat. Prod. 2008, 71, 2038-2040.
66. Adelekan, A.M.; Prozesky, E.A.; Hussein, A.A.; Urena, L.D.; van Rooyen, P.H.; Liles, D.C.; Meyer, J.J.; Rodriguez, B. Bioactive diterpenes and other constituents of Croton steenkampianus. J. Nat. Prod. 2008, 71, 1919-1922.
67. Matsuno, Y.; Deguchi, J.; Hirasawa, Y.; Ohyama, K.; Toyoda, H.; Hirobe, C.; Ekasari, W.; Widyawaruyanti, A.; Zaini, N.C.; Morita, H. Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida. Bioorg. Med. Chem. Lett. 2008, 18, 3774-3777.
68. Kamatou, G.P.P.; Van Zyl, R.L.; Davids, H.; Heerden, F.R.V.; Lourens, A.C.U.; Viljoen, A.M. Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula. S. Afr. J. Bot. 2008, 74, 238-243.
69. Chukwujekwu, J.C.; Lategan, C.A.; Smith, P.J.; Van Heerden, F.R.; Van Staden, J. Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata. S. Afr. J. Bot. 2009, 75, 176-179.
70. Olagnier, D.; Costes, P.; Berry, A.; Linas, M.D.; Urrutigoity, M.; Dechy-Cabaret, O.; Benoit- Vical, F. Modifications of the chemical structure of terpenes in antiplasmodial and antifungal drug research. Bioorg. Med. Chem. Lett. 2007, 17, 6075-6078.
71. Ngouamegne, E.T.; Fongang, R.S.; Ngouela, S.; Boyom, F.F.; Rohmer, M.; Tsamo, E.; Gut, J.; Rosenthal, P J. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem. Pharm. Bull. (Tokyo) 2008, 56, 374-377.
72. Moon, H.I. Antiplasmodial activity of ineupatorolides A from Carpesium rosulatum. Parasitol. Res. 2007, 100, 1147-1149.
73. Chung, I.M.; Kim, M.Y.; Moon, H.I. Antiplasmodial activity of sesquiterpene lactone from Carpesium rosulatum in mice. Parasitol. Res. 2008, 103, 341-344.
74. De Sa, M.S.; Costa, J.F.; Krettli, A.U.; Zalis, M.G.; Maia, G.L.; Sette, I.M.; Camara, C.D.; Filho, J.M.; Giulietti-Harley, A.M.; Ribeiro Dos Santos, R.; Soares, M.B. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. bergheiinfected mice. Parasitol. Res. 2009, 105, 275-279.
75. Ortet, R.; Prado, S.; Mouray, E.; Thomas, O.P. Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum. Phytochemistry 2008, 69, 2961-2965.
76. Afolayan, A.F.; Mann, M.G.; Lategan, C.A.; Smith, P.J.; Bolton, J.J.; Beukes, D.R. Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum. Phytochemistry 2009, 70, 597-600.
77. Zhang, H.; Wang, X.; Chen, F.; Androulakis, X. M.; Wargovich, M. J. Anticancer activity of limonoid from Khaya senegalensis. Phytother. Res. 2007, 21, 731-734.
78. Roy, A.; Saraf, S. Limonoids: Overview of significant bioactive triterpenes distributed in plant kingdom. Biol. Pharm. Bull. 2006, 29, 191-201.
79. Mohamad, K.; Hirasawa, Y.; Litaudon, M.; Awang, K.; Hadi, A.H.; Takeya, K.; Ekasari, W.; Widyawaruyanti, A.; Zaini, N.C.; Morita, H. Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus. Bioorg Med Chem 2009, 17, 727-730.
80. Banzouzi, J.T.; Soh, P.N.; Mbatchi, B.; Cave, A.; Ramos, S.; Retailleau, P.; Rakotonandrasana, O.; Berry, A.; Benoit-Vical, F. Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity. Planta Med. 2008, 74, 1453-1456.
81. Muiva, L.M.; Yenesew, A.; Derese, S.; Heydenreich, M.; Peter, M.G.; Akala, H.M.; Eyase, F.; Waters, N.C.; Mutai, C.; Keriko, J.M.; Walsh, D. Antiplasmodial ß-hydroxydihydrochalcone from seedpods of Tephrosia elata. Phytochem. Lett. 2009, in press, doi:10.1016/j.phytol.2009.01.002.
82. Kunert, O.; Swamy, R.C.; Kaiser, M.; Presser, A.; Buzzi, S.; Appa-Rao, A.V.N.; Shuhly, W. Antiplasmodial and leishmanicidal activity of biflavonoids from Indian Selaginella bryopteris. Phytochem. Lett. 2008, 1, 171-174.
83. Oshimi, S.; Tomizawa, Y.; Hirasawa, Y.; Honda, T.; Ekasari, W.; Widyawaruyanti, A.; Rudyanto, M.; Indrayanto, G.; Zaini, N.C.; Morita, H. Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A. Bioorg. Med. Chem. Lett. 2008, 18, 3761-3763.
84. Zelefack, F.; Guilet, D.; Fabre, N.; Bayet, C.; Chevalley, S.; Ngouela, S.; Lenta, B. N.; Valentin, A.; Tsamo, E.; Dijoux-Franca, M. G. Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. J. Nat. Prod. 2009, 72, 954-957.
85. Martin, F.; Hay, A.E.; Cressende, D.; Reist, M.; Vivas, L.; Gupta, M.P.; Carrupt, P.A.; Hostettmann, K. Antioxidant c-glucosylxanthones from the leaves of Arrabidaea patellifera. J. Nat. Prod. 2008, 71, 1887-1890.
86. Hou, Y.; Cao, S.; Brodie, P.J.; Callmander, M.W.; Ratovoson, F.; Rakotobe, E.A.; Rasamison, V. E.; Ratsimbason, M.; Alumasa, J.N.; Roepe, P.D.; Kingston, D.G. Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest. Bioorg. Med. Chem. 2009, 17, 2871-2876.
87. Ziegler, H.L.; Hansen, H.S.; Staerk, D.; Christensen, S.B.; Hägerstrand, H.; Jaroszewski, J.W. The antiparasitic compound licochalcone A is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed. Antimicrob. Agents Chemother. 2004, 48, 4067-4071.
88. Mishra, L.C.; Bhattacharya, A.; Bhasin, V.K. Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro. Acta Trop. 2009, 109, 194-198.
89. Lehane, A.M.; Saliba, K.J. Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite. BMC Res. Notes 2008, 1, 26.
90. Moein, M.R.; Pawar, R.S.; Khan, S.I.; Tekwani, B.L.; Khan, I.A. Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo. Phytother. Res. 2008, 22, 283-285.
91. Ajaiyeoba, E.O.; Oladepo, O.; Fawole, O.I.; Bolaji, O.M.; Akinboye, D.O.; Ogundahunsi, O.A.T.; Falade, C.O.; Gbotosho, G.O.; Itiola, O.A.; Happi, T.C.; Ebong, O.O.; Ononiwu, I.M.; Osowole, O.S.; Oduola, O.O.; Ashidi, J.S.; Oduola, A.M.J. Cultural categorization of febrile illnesses in correlation with herbal remedies for treatment in Southwestern Nigeria. J. Ethnopharmacol. 2003, 85,179-185.
92. Ajaiyeoba, E.O.; Bolaji, O.M.; Akinboye, D.O.; Falade, C.O.; Gbotosho, G.O.; Ashidi, J.S.; Okpako, L.C.; Oduola, O.O.; Falade, M.O.; Itiola, O.A.; Houghton, P.J.; Wright, C.W.; Ogundahunsi, O.A.; Oduola, A.M.J. In vitro antiplasmodial and cytotoxic activities of plants used as antimalarial agents in the southwest Nigerian ethnomedicine. J. Nat. Rem. 2005, 5, 1-6.
93. Ajaiyeoba, E.O.; Ashidi, J.S.; Okpako, L.C.; Houghton, P.J.; Wright, C.W. Antiplasmodial compounds from Cassia siamea stem bark extract. Phytother. Res. 2008, 22, 254-255.
94. Ramanandraibe, V.; Grellier, P.; Martin, M.T.; Deville, A.; Joyeau, R.; Ramanitrahasimbola, D.; Mouray, E.; Rasoanaivo, P.; Mambu, L. Antiplasmodial phenolic compounds from Piptadenia pervillei. Planta Med. 2008, 74, 417-421.
95. Roumy, V.; Fabre, N.; Portet, B.; Bourdy, G.; Acebey, L.; Vigor, C.; Valentin, A.; Moulis, C. Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis. Phytochemistry 2009, 70, 305-311.
96. Flores, N.; Jimenez, I.A.; Gimenez, A.; Ruiz, G.; Gutierrez, D.; Bourdy, G.; Bazzocchi, I.L. Benzoic acid derivatives from Piper species and their antiparasitic activity. J. Nat. Prod. 2008, 71, 1538-1543.
97. Marti, G.; Eparvier, V.; Moretti, C.; Susplugas, S.; Prado, S.; Grellier, P.; Retailleau, P.; Guéritte, F.; Litaudon, M. Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae). Phytochemistry 2009, 70, 75-85.
98. Tasdemir, D.; Brun, R.; Franzblau, S.G.; Sezgin, Y.; Çalis, I. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine 2008, 15, 209-215.
99. Flores, N.; Jimenez, I.A.; Gimenez, A.; Ruiz, G.; Gutierrez, D.; Bourdy, G.; Bazzocchi, I.L. Antiparasitic activity of prenylated benzoic acid derivatives from Piper species. Phytochemistry 2009, 70, 621-627.
100. de Andrade-Neto, V.F.; da Silva, T.; Lopes, L.M.; do Rosario, V.E.; de Pilla Varotti, F.; Krettli, A.U. Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis. Antimicrob. Agents Chemother. 2007, 51, 2346-2350.
101. Lee, S.J.; Park, W.H.; Moon, H.I. Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl. Parasitol. Res. 2009, 104, 463-466.
102. Abrantes, M.; Mil-Homens, T.; Duarte, N.; Lopes, D.; Cravo, P.; Madureira, M.; Ferreira, M.J. Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis. Planta Med. 2008, 74, 1408-1412.
103. Willcox, M.L.; Bodeker, G. Traditional herbal medicines for malaria. Brit. Med. J. 2004, 329, 1156-1159.
104. Harborne, J.B. Twenty-five years of chemical ecology. Nat. Prod. Rep. 2001, 18, 361-379.