Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Liu, Qinlong ^a   Rehman, Hasibur ^a   Shi, Yanjun ^a   Krishnasamy, Yasodha ^a   Lemasters, John J ^a,b   Smith, Charles D ^a,c   Zhong, Zhi ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c APOGEE BIOTECHNOLOGY CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC 294640; ALANINE AMINOTRANSFERASE; ALPHA CHEMOKINE; BILIRUBIN; ENZYME INHIBITOR; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; SPHINGOSINE KINASE 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BILIRUBIN BLOOD LEVEL; CD4+ T LYMPHOCYTE; CELL COUNT; CELL EXPANSION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; GRAFT FAILURE; GRAFT SURVIVAL; HYPERBILIRUBINEMIA; INFLAMMATION; LIVER GRAFT; LIVER TRANSPLANTATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MONOCYTE; NECROSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT;

ADAMANTANE; ANIMALS; CELL ADHESION MOLECULES; CHEMOKINES; ENZYME INHIBITORS; INFLAMMATION; LEUKOCYTES; LIVER; LIVER TRANSPLANTATION; LYSOPHOSPHOLIPIDS; MALE; NF-KAPPA B; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PYRIDINES; RATS; RATS, INBRED LEW; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SPHINGOSINE; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

RATTUS;

EID: 84864371831     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041834     Document Type: Article

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