NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 327, Issue 3, 2008, Pages 699-706

  Rehman, Hasibur ^a   Ramshesh, Venkat K ^a   Theruvath, Tom P ^a   Kim, Insil ^a   Currin, Robert T ^c   Giri, Shailendra ^a   Lemasters, John J ^a,b   Zhong, Zhi ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCEIN; COLLAGEN; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; CYTOCHROME C; MESSENGER RNA; PROCOLLAGEN; PROPIDIUM IODIDE; RHODAMINE 123; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME RELEASE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTRAHEPATIC CHOLESTASIS; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; MALE; MITOCHONDRIAL PERMEABILITY; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL DEATH; CHOLESTASIS; COLLAGEN; CYCLOSPORINE; FIBROSIS; HEPATOCYTES; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; PERMEABILITY;

EID: 57349138389     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.143578     Document Type: Article

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