Role of free radicals in primary nonfunction of marginal fatty grafts from rats treated acutely with ethanol

Molecular Pharmacology

Volumn 52, Issue 5, 1997, Pages 912-919

  Zhong, Zhi ^a   Connor, Henry ^a   Stachlewitz, Robert F ^a   Von Frankenberg, Moritz ^a   Mason, Ronald P ^c   Lemasters, John J ^b   Thurman, Ronald G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLOPURINOL; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATECHIN; FREE RADICAL; GADOLINIUM CHLORIDE; LIPID HYDROPEROXIDE; MALONALDEHYDE; N TERT BUTYL ALPHA (4 PYRIDYL 1 OXIDE) NITRONE; PHORBOL 13 ACETATE 12 MYRISTATE; SCAVENGER; SUPEROXIDE; UNIVERSITY OF WISCONSIN SOLUTION; XANTHINE OXIDASE INHIBITOR;

ALCOHOL CONSUMPTION; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FATTY LIVER; FEMALE; GRAFT FAILURE; GRAFT PRESERVATION; INTRAVENOUS DRUG ADMINISTRATION; KUPFFER CELL; LEUKOCYTE ADHERENCE; LIPID PEROXIDATION; LIVER TRANSPLANTATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030781506     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.5.912     Document Type: Article

References (43)

1. D'Alessandro, A. M., M. Kalayoglu, H. W. Sollinger, R. M. Hoffman, A. Reed, S. J. Knechtle, J. D. Pirsch, G. R. Hafez, D. Lerentzen, and F. O. Belzer. The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation. Transplantation 51:157-163 (1991).
2. Anonymous. Update: alcohol-related traffic fatalities - United States, 1982-1993. Morb. Mortal. Wkly. Rep. 43:861-867 (1994).
3. Hassanein, T. I., J. S. Gavaler, D. Fishkin, R. Gordon, T. E. Starzl, and D. H. Van Thiel. Does the presence of a measurable blood alcohol level in a potential organ donor affect the outcome of liver transplantation? Alcohol. Clin. Exp. Res. 15:300-303 (1991).
4. Connor, H. D., W. Gao, S. Nukina, J. J. Lemasters, R. P. Mason, and R. G. Thurman. Free radicals are involved in graft failure following orthotopic liver transplantation: an EPR spin trapping study. Transplantation 54: 199-204 (1992).
5. Shaw, S., E. Jayatilleke, W. A. Ross, E. R. Gordon, and S. Lieber. Ethanol-induced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine. J. Lab. Clin. Med. 98:417-124 (1981).
6. Spencer, S., K. P. Rubin, and C. S. Lieber. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: evidence of lipid peroxidation. Dig. Dis. Sci. 28:585-589 (1983).
7. Reinke, L. A., E. K. Lai, C. M. DuBose, and P. B. McCay. Reactive free radical generation in the heart and liver of ethanol-fed rats: correlation with in vitro radical formation. Proc. Natl. Acad. Sci. USA 84:9223-9227 (1987).
8. Knecht, K. T., B. U. Bradford, R. P. Mason, and R. G. Thurman. In vivo formation of a free radical metabolite of ethanol. Mol. Pharmacol. 38: 26-30 (1990).
9. Ylikahri, R. H., M. T. Kähönen, and I. Hassinen. Modification of metabolic effects of ethanol by fructose. Acta Med. Scand. 30:141-150 (1972).
10. Zhong, Z., H. Connor, R. P. Mason, W. Qu, R. F. Stachlewitz, W. Gao, J. J. Lemasters, and R. G. Thurman. Destruction of Kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol-treated rats. Liver Transplant. Surg 2:383-387 (1996).
11. Hardonk, M. J., F. W. J. Dijkhuis, C. E. Hulstaert, and J. Koudstaal. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J. Leukoc. Biol. 52:296-302 (1992).
12. Cohen, P. J. Allopurinol administered prior to hepatic ischemia in the rat prevents chemiluminescence following restoration of circulation. Can. J. Anaesth. 39:1090-1093 (1992).
13. Zimmermann, F. A., G. W. Butcher, H. S. Davies, G. Brons, N. Kamada, and O. Türel. Techniques of orthotopic liver transplantation in the rat and some studies of the immunologic response to fully allogenic liver grafts. Transplant. Proc. 1:571-577 (1979).
14. Ohishi, N., H. Ohkawa, A. Miike, T. Tatano, and K. Yagi. A new assay method for lipid peroxides using a methylene blue derivative. Biochem. Int. 10:205-211 (1985).
15. Bergmeyer, H. U. Methods of Enzymatic Analysis. Academic Press, New York (1988).
16. Labarca, C., and K. Paigen. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344-352 (1980).
17. Remmer, H., J. Schenkman, R. W. Estabrook, H. Sasame, J. Gillette, S. Narashimhulu, D. Y. Cooper, and O. Rosenthal. Drug interaction with hepatic microsomal cytochrome. Mol. Pharmacol. 2:187-190 (1966).
18. Greenwald, R. A. Handbook of Methods for Oxygen Radical Research (R. A. Greenwald, ed.). CRC Press, Boca Raton (1985).
19. Lowry, O. H., N. J. Rosenbrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin phenol regent. J. Biol. Chem. 193:265-275 (1951).
20. Stachlewitz, R. F., W. Gao, Z. Zhong, H. D. Connor, J. J. Lemasters, R. P. Mason, and R. G. Thurman. Antioxidant-insensitive free radical production by white blood cells (WBCs) isolated from alcohol treated livers after transplantation. Toxicologist 15:27 (1995).
21. McCord, J. M., and I. Fridovich. Superoxide dismutase: an enzymatic function of erythrocuprein (hemocuprein). J. Biol. Chem. 244:6049-6055 (1969).
22. Chamulitrat, W., S. J. Jordan, and R. P. Mason. Fatty acid radical formation in rats administered oxidized fatty acids: in vivo spin trapping investigation. Arch. Biochem. Biophys. 299:361-367 (1992).
23. Slater, T. F. Free radical scavengers, in (+)-Cyanidanol-3 in Diseases of the Liver, International Workshop (H. O. Conn, ed.). Academic Press Inc., Crans-Montana, Switzerland, 11-15 (1981).
24. Jaeschke, H., A. P. Bautista, Z. Spolarics, and J. J. Spitzer. Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats. J. Leukoc. Biol. 52:377-382 (1992).
25. Zhong, Z., H. D. Connor, R. P. Mason, W. Qu, W. Gao, J. J. Lemasters, and R. G. Thurman. Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats. J. Pharmacol. Exp. Ther. 27:1512-1517 (1995).
26. Gao, W., H. D. Connor, J. J. Lemasters, R. P. Mason, and R. G. Thurman. Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species. Transplantation 59: 674-679 (1995).
27. Lemasters, J. J., J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, I. Marzi, and R. G. Thurman. Endothelial cell killing and activation of Kupffer cells following reperfusion of rat liver stored in Euro-Collins solution, in Cells of the Hepatic Sinusoid II (E. Wisse, D. L. Knook and K. Decker, eds.). The Kupffer Cell Foundation, Rijswijk, The Netherlands, 277-280 (1989).
28. Bouwens, L. Structural and functional aspects of Kupffer cells. Rev. Biol. Cell. 16:69-94 (1988).
29. Bautista, A. P., and J. J. Spitzer. Acute ethanol intoxication stimulates superoxide anion production by in situ perfused rat liver. Hepatology 15:892-898 (1992).
30. D'Souza, N. B., G. J. Bagby, C. H. Lang, I. V. Deaciuc, and J. J. Spitzer. Ethanol alters the metabolic response of isolated, perfused rat liver to a phagocytic stimulus. Alcohol. Clin. Exp. Res. 17:147-154 (1993).
31. Bautista, A. P., and J. J. Spitzer. Cross-tolerance between acute alcohol-intoxication and endotoxemia. Alcohol. Clin. Exp. Res. 20:1395-1400 (1996).
32. Enomoto, N., K. Ikejima, B. U. Bradford, C. A. Wall, H. Kono, and R. G. Thurman. Alcohol causes both tolerance and sensitization of Kupffer cells via mechanisms dependent on endotoxin. Hepatology, in press.
33. Thurman, R. G., E. Savier, Y. Adachi, S. I. Shedlofsky, J. J. Lemasters, W. Gao, B. U. Bradford, Z. Zhong, K. T. Knecht, W. Qu, R. T. Currin, S. Lichtman, J. Wang, and M. Goto. Cytokines in liver transplantation and alcoholic liver disease, in Cytokines and the Liver (W. Gerok, K. Decker, T. Andus and V. Gross, eds.). Kluwer Academic Publishers, Lancaster, UK, 185-203 (1995).
34. Yuki, T., and R. G. Thurman. The swift increase in alcohol metabolism: Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis. Biochem. J. 186:119-126 (1980).
35. Fantone, J. C., and P. A. Ward. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol. 107:397-418 (1982).
36. Thurman, R. G., W. Gao, H. Connor, R. P. Mason, J. J. Lemasters, R. Bozigian, and R. M. Adams. SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat. Transplant. Int. 7:S167-S170 (1994).
37. Egan, R. W., P. H. Gale, and F. A. Kuehl. Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase. J. Biol. Chem. 254:3295-3302 (1979).
38. Wiezorek, J. S., D. H. Brown, D. E. Kupperman, and C. A. Brass. Rapid conversion to high xanthine oxidase activity in viable Kupffer cells during hypoxia. J. Clin. Invest. 94:2224-2230 (1994).
39. Bell, F. P., A. M. Manning, and H. Jaeschke. Activation of nuclear factor-κB (NF-κB) and expression of intracellular adhesion molecule-1 (ICAM-1) mRNA during hepatic ischemia-reperfusion. Hepatology 22: 381A (1995).
40. Lin, M., T. V. Pham, and T. Tsukamoto. In vivo suppression of Kupffer cell NF-κB activation and cytokine gene expression by iron chelator. Hepatology 22:365A (1995).
41. Rosales, C., and R. L. Juliano. Signal transduction by cell adhesion receptors in leukocytes. J. Leukoc. Biol. 59:189-198 (1995).
42. von Frankenberg, M., H. K. Bojes, Y. Iimuro, R. Schoonhoven, J. J. Lemasters, and R. G. Thurman. ICAM-1 is elevated dramatically in fatty liver grafts from alcohol-treated rats. Hepatology 22:438 (1995).
43. Jha, H. V., G. Recklinghausen, and F. Zilliken. Inhibition of in vitro microsomal lipid peroxidation by isoflavanoids. Biochem. Pharmacol. 34: 1367-1369 (1985).