-
3
-
-
0035797119
-
Mitochondria make a come back
-
Scheffler I.E. Mitochondria make a come back. Adv. Drug Deliv. Rev. 2001, 49:3-26.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.49
, pp. 3-26
-
-
Scheffler, I.E.1
-
4
-
-
77952885088
-
The role of mitochondria in the mammalian antiviral defense system
-
Scott I. The role of mitochondria in the mammalian antiviral defense system. Mitochondrion 2010, 10:316-320.
-
(2010)
Mitochondrion
, vol.10
, pp. 316-320
-
-
Scott, I.1
-
5
-
-
33746466098
-
Mitochondrial mutations in cancer
-
Brandon M., Baldi P., Wallace D.C. Mitochondrial mutations in cancer. Oncogene 2006, 25:4647-4662.
-
(2006)
Oncogene
, vol.25
, pp. 4647-4662
-
-
Brandon, M.1
Baldi, P.2
Wallace, D.C.3
-
6
-
-
84858676832
-
A mitochondrial etiology of Alzheimer and Parkinson disease
-
Coskun P., Wyrembak J., Schriner S., Chen H.W., Marciniack C., Laferla F., Wallace D.C. A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim. Biophys. Acta 2011.
-
(2011)
Biochim. Biophys. Acta
-
-
Coskun, P.1
Wyrembak, J.2
Schriner, S.3
Chen, H.W.4
Marciniack, C.5
Laferla, F.6
Wallace, D.C.7
-
7
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
-
Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 2005, 39:359-407.
-
(2005)
Annu. Rev. Genet.
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
8
-
-
77953507107
-
Mitochondrial DNA mutations in disease and aging
-
Wallace D.C. Mitochondrial DNA mutations in disease and aging. Environ. Mol. Mutagen. 2010, 51:440-450.
-
(2010)
Environ. Mol. Mutagen.
, vol.51
, pp. 440-450
-
-
Wallace, D.C.1
-
9
-
-
70450231612
-
Energetics, epigenetics, mitochondrial genetics
-
Wallace D.C., Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion 2010, 10:12-31.
-
(2010)
Mitochondrion
, vol.10
, pp. 12-31
-
-
Wallace, D.C.1
Fan, W.2
-
11
-
-
39649120348
-
Inherited mitochondrial diseases of DNA replication
-
Copeland W.C. Inherited mitochondrial diseases of DNA replication. Annu. Rev. Med. 2008, 59:131-146.
-
(2008)
Annu. Rev. Med.
, vol.59
, pp. 131-146
-
-
Copeland, W.C.1
-
12
-
-
0029587469
-
Molecular genetic aspects of human mitochondrial disorders
-
Larsson N.G., Clayton D.A. Molecular genetic aspects of human mitochondrial disorders. Annu. Rev. Genet. 1995, 29:151-178.
-
(1995)
Annu. Rev. Genet.
, vol.29
, pp. 151-178
-
-
Larsson, N.G.1
Clayton, D.A.2
-
14
-
-
42049114034
-
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
-
Scarpulla R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 2008, 88:611-638.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 611-638
-
-
Scarpulla, R.C.1
-
15
-
-
79952461851
-
The core human mitochondrial transcription initiation complex: it only takes two to tango
-
Shutt T.E., Bestwick M., Shadel G.S. The core human mitochondrial transcription initiation complex: it only takes two to tango. Transcription 2011, 2:55-59.
-
(2011)
Transcription
, vol.2
, pp. 55-59
-
-
Shutt, T.E.1
Bestwick, M.2
Shadel, G.S.3
-
16
-
-
0026640728
-
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein
-
Fisher R.P., Lisowsky T., Parisi M.A., Clayton D.A. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J. Biol. Chem. 1992, 267:3358-3367.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 3358-3367
-
-
Fisher, R.P.1
Lisowsky, T.2
Parisi, M.A.3
Clayton, D.A.4
-
17
-
-
0025829045
-
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins
-
Parisi M.A., Clayton D.A. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 1991, 252:965-969.
-
(1991)
Science
, vol.252
, pp. 965-969
-
-
Parisi, M.A.1
Clayton, D.A.2
-
18
-
-
0035281548
-
HMG1 and 2, and related 'architectural' DNA-binding proteins
-
Thomas J.O., Travers A.A. HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci. 2001, 26:167-174.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 167-174
-
-
Thomas, J.O.1
Travers, A.A.2
-
19
-
-
0029006975
-
Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation
-
Dairaghi D.J., Shadel G.S., Clayton D.A. Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim. Biophys. Acta 1995, 1271:127-134.
-
(1995)
Biochim. Biophys. Acta
, vol.1271
, pp. 127-134
-
-
Dairaghi, D.J.1
Shadel, G.S.2
Clayton, D.A.3
-
20
-
-
2442431673
-
Mitochondrial transcription factor A regulates mtDNA copy number in mammals
-
Ekstrand M.I., Falkenberg M., Rantanen A., Park C.B., Gaspari M., Hultenby K., Rustin P., Gustafsson C.M., Larsson N.G. Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum. Mol. Genet. 2004, 13:935-944.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 935-944
-
-
Ekstrand, M.I.1
Falkenberg, M.2
Rantanen, A.3
Park, C.B.4
Gaspari, M.5
Hultenby, K.6
Rustin, P.7
Gustafsson, C.M.8
Larsson, N.G.9
-
21
-
-
34548495323
-
The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures
-
Kaufman B.A., Durisic N., Mativetsky J.M., Costantino S., Hancock M.A., Grutter P., Shoubridge E.A. The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol. Biol. Cell 2007, 18:3225-3236.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 3225-3236
-
-
Kaufman, B.A.1
Durisic, N.2
Mativetsky, J.M.3
Costantino, S.4
Hancock, M.A.5
Grutter, P.6
Shoubridge, E.A.7
-
22
-
-
0031930319
-
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
-
Larsson N.G., Wang J., Wilhelmsson H., Oldfors A., Rustin P., Lewandoski M., Barsh G.S., Clayton D.A. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat. Genet. 1998, 18:231-236.
-
(1998)
Nat. Genet.
, vol.18
, pp. 231-236
-
-
Larsson, N.G.1
Wang, J.2
Wilhelmsson, H.3
Oldfors, A.4
Rustin, P.5
Lewandoski, M.6
Barsh, G.S.7
Clayton, D.A.8
-
23
-
-
80555128721
-
The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA
-
Ngo H.B., Kaiser J.T., Chan D.C. The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat. Struct. Mol. Biol. 2011, 18:1290-1296.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 1290-1296
-
-
Ngo, H.B.1
Kaiser, J.T.2
Chan, D.C.3
-
24
-
-
80555122761
-
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter
-
Rubio-Cosials A., Sidow J.F., Jimenez-Menendez N., Fernandez-Millan P., Montoya J., Jacobs H.T., Coll M., Bernado P., Sola M. Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nat. Struct. Mol. Biol. 2011, 18:1281-1289.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 1281-1289
-
-
Rubio-Cosials, A.1
Sidow, J.F.2
Jimenez-Menendez, N.3
Fernandez-Millan, P.4
Montoya, J.5
Jacobs, H.T.6
Coll, M.7
Bernado, P.8
Sola, M.9
-
25
-
-
0036648997
-
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
-
Falkenberg M., Gaspari M., Rantanen A., Trifunovic A., Larsson N.G., Gustafsson C.M. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat. Genet. 2002, 31:289-294.
-
(2002)
Nat. Genet.
, vol.31
, pp. 289-294
-
-
Falkenberg, M.1
Gaspari, M.2
Rantanen, A.3
Trifunovic, A.4
Larsson, N.G.5
Gustafsson, C.M.6
-
26
-
-
77952329046
-
Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro
-
Lodeiro M.F., Uchida A.U., Arnold J.J., Reynolds S.L., Moustafa I.M., Cameron C.E. Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J. Biol. Chem. 2010, 285:16387-16402.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16387-16402
-
-
Lodeiro, M.F.1
Uchida, A.U.2
Arnold, J.J.3
Reynolds, S.L.4
Moustafa, I.M.5
Cameron, C.E.6
-
27
-
-
77955456575
-
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro
-
Shutt T.E., Lodeiro M.F., Cotney J., Cameron C.E., Shadel G.S. Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:12133-12138.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 12133-12138
-
-
Shutt, T.E.1
Lodeiro, M.F.2
Cotney, J.3
Cameron, C.E.4
Shadel, G.S.5
-
28
-
-
70449807055
-
TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase
-
Sologub M., Litonin D., Anikin M., Mustaev A., Temiakov D. TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase. Cell 2009, 139:934-944.
-
(2009)
Cell
, vol.139
, pp. 934-944
-
-
Sologub, M.1
Litonin, D.2
Anikin, M.3
Mustaev, A.4
Temiakov, D.5
-
29
-
-
0031464189
-
On the evolution of the single-subunit RNA polymerases
-
Cermakian N., Ikeda T.M., Miramontes P., Lang B.F., Gray M.W., Cedergren R. On the evolution of the single-subunit RNA polymerases. J. Mol. Evol. 1997, 45:671-681.
-
(1997)
J. Mol. Evol.
, vol.45
, pp. 671-681
-
-
Cermakian, N.1
Ikeda, T.M.2
Miramontes, P.3
Lang, B.F.4
Gray, M.W.5
Cedergren, R.6
-
30
-
-
0022497229
-
Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome
-
Greenleaf A.L., Kelly J.L., Lehman I.R. Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:3391-3394.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 3391-3394
-
-
Greenleaf, A.L.1
Kelly, J.L.2
Lehman, I.R.3
-
31
-
-
0023649273
-
Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7
-
Masters B.S., Stohl L.L., Clayton D.A. Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell 1987, 51:89-99.
-
(1987)
Cell
, vol.51
, pp. 89-99
-
-
Masters, B.S.1
Stohl, L.L.2
Clayton, D.A.3
-
32
-
-
0029866234
-
Sequences homologous to yeast mitochondrial and bacteriophage T3 and T7 RNA polymerases are widespread throughout the eukaryotic lineage
-
Cermakian N., Ikeda T.M., Cedergren R., Gray M.W. Sequences homologous to yeast mitochondrial and bacteriophage T3 and T7 RNA polymerases are widespread throughout the eukaryotic lineage. Nucleic Acids Res. 1996, 24:648-654.
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 648-654
-
-
Cermakian, N.1
Ikeda, T.M.2
Cedergren, R.3
Gray, M.W.4
-
33
-
-
0030943170
-
Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database
-
Tiranti V., Savoia A., Forti F., D'Apolito M.F., Centra M., Rocchi M., Zeviani M. Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database. Hum. Mol. Genet. 1997, 6:615-625.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 615-625
-
-
Tiranti, V.1
Savoia, A.2
Forti, F.3
D'Apolito, M.F.4
Centra, M.5
Rocchi, M.6
Zeviani, M.7
-
34
-
-
31444454598
-
Bacteriophage origins of mitochondrial replication and transcription proteins
-
Shutt T.E., Gray M.W. Bacteriophage origins of mitochondrial replication and transcription proteins. Trends Genet. 2006, 22:90-95.
-
(2006)
Trends Genet.
, vol.22
, pp. 90-95
-
-
Shutt, T.E.1
Gray, M.W.2
-
35
-
-
80054015954
-
Structure of human mitochondrial RNA polymerase
-
Ringel R., Sologub M., Morozov Y.I., Litonin D., Cramer P., Temiakov D. Structure of human mitochondrial RNA polymerase. Nature 2011, 478:269-273.
-
(2011)
Nature
, vol.478
, pp. 269-273
-
-
Ringel, R.1
Sologub, M.2
Morozov, Y.I.3
Litonin, D.4
Cramer, P.5
Temiakov, D.6
-
36
-
-
0028206048
-
Function and structure relationships in DNA polymerases
-
Joyce C.M., Steitz T.A. Function and structure relationships in DNA polymerases. Annu. Rev. Biochem. 1994, 63:777-822.
-
(1994)
Annu. Rev. Biochem.
, vol.63
, pp. 777-822
-
-
Joyce, C.M.1
Steitz, T.A.2
-
37
-
-
84864297661
-
Biochemical characterization of human mitochondrial RNA polymerase reveals differences in formation and fidelity of elongation complexes relative to T7 RNA polymerase
-
Smidansky E.D., Arnold J.J., Reynolds S., Cameron C.E. Biochemical characterization of human mitochondrial RNA polymerase reveals differences in formation and fidelity of elongation complexes relative to T7 RNA polymerase. Mitochondrion 2010, 10:214.
-
(2010)
Mitochondrion
, vol.10
, pp. 214
-
-
Smidansky, E.D.1
Arnold, J.J.2
Reynolds, S.3
Cameron, C.E.4
-
38
-
-
33845967859
-
Transient state kinetics of transcription elongation by T7 RNA polymerase
-
Anand V.S., Patel S.S. Transient state kinetics of transcription elongation by T7 RNA polymerase. J. Biol. Chem. 2006, 281:35677-35685.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35677-35685
-
-
Anand, V.S.1
Patel, S.S.2
-
39
-
-
0033579380
-
Structure of a transcribing T7 RNA polymerase initiation complex
-
Cheetham G.M., Steitz T.A. Structure of a transcribing T7 RNA polymerase initiation complex. Science 1999, 286:2305-2309.
-
(1999)
Science
, vol.286
, pp. 2305-2309
-
-
Cheetham, G.M.1
Steitz, T.A.2
-
40
-
-
0035378427
-
T 7 RNA polymerase
-
Sousa R. T 7 RNA polymerase. Uirusu 2001, 51:81-94.
-
(2001)
Uirusu
, vol.51
, pp. 81-94
-
-
Sousa, R.1
-
41
-
-
25144515314
-
Major conformational changes during T7RNAP transcription initiation coincide with, and are required for, promoter release
-
Guo Q., Nayak D., Brieba L.G., Sousa R. Major conformational changes during T7RNAP transcription initiation coincide with, and are required for, promoter release. J. Mol. Biol. 2005, 353:256-270.
-
(2005)
J. Mol. Biol.
, vol.353
, pp. 256-270
-
-
Guo, Q.1
Nayak, D.2
Brieba, L.G.3
Sousa, R.4
-
42
-
-
33645097171
-
Translocation by T7 RNA polymerase: a sensitively poised Brownian ratchet
-
Guo Q., Sousa R. Translocation by T7 RNA polymerase: a sensitively poised Brownian ratchet. J. Mol. Biol. 2006, 358:241-254.
-
(2006)
J. Mol. Biol.
, vol.358
, pp. 241-254
-
-
Guo, Q.1
Sousa, R.2
-
43
-
-
79958055322
-
TEFM (c17orf42) is necessary for transcription of human mtDNA
-
Minczuk M., He J., Duch A.M., Ettema T.J., Chlebowski A., Dzionek K., Nijtmans L.G., Huynen M.A., Holt I.J. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res. 2011, 39:4284-4299.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 4284-4299
-
-
Minczuk, M.1
He, J.2
Duch, A.M.3
Ettema, T.J.4
Chlebowski, A.5
Dzionek, K.6
Nijtmans, L.G.7
Huynen, M.A.8
Holt, I.J.9
-
44
-
-
11144357677
-
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro
-
Endoh M., Zhu W., Hasegawa J., Watanabe H., Kim D.K., Aida M., Inukai N., Narita T., Yamada T., Furuya A., Sato H., Yamaguchi Y., Mandal S.S., Reinberg D., Wada T., Handa H. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol. Cell. Biol. 2004, 24:3324-3336.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3324-3336
-
-
Endoh, M.1
Zhu, W.2
Hasegawa, J.3
Watanabe, H.4
Kim, D.K.5
Aida, M.6
Inukai, N.7
Narita, T.8
Yamada, T.9
Furuya, A.10
Sato, H.11
Yamaguchi, Y.12
Mandal, S.S.13
Reinberg, D.14
Wada, T.15
Handa, H.16
-
45
-
-
40849094161
-
Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa
-
Johnson S.J., Close D., Robinson H., Vallet-Gely I., Dove S.L., Hill C.P. Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. J. Mol. Biol. 2008, 377:1460-1473.
-
(2008)
J. Mol. Biol.
, vol.377
, pp. 1460-1473
-
-
Johnson, S.J.1
Close, D.2
Robinson, H.3
Vallet-Gely, I.4
Dove, S.L.5
Hill, C.P.6
-
46
-
-
33846525436
-
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export
-
Yoh S.M., Cho H., Pickle L., Evans R.M., Jones K.A. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 2007, 21:160-174.
-
(2007)
Genes Dev.
, vol.21
, pp. 160-174
-
-
Yoh, S.M.1
Cho, H.2
Pickle, L.3
Evans, R.M.4
Jones, K.A.5
-
48
-
-
0032518398
-
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
-
Doublie S., Tabor S., Long A.M., Richardson C.C., Ellenberger T. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature 1998, 391:251-258.
-
(1998)
Nature
, vol.391
, pp. 251-258
-
-
Doublie, S.1
Tabor, S.2
Long, A.M.3
Richardson, C.C.4
Ellenberger, T.5
-
49
-
-
0037388383
-
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
-
Johnson S.J., Taylor J.S., Beese L.S. Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:3895-3900.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 3895-3900
-
-
Johnson, S.J.1
Taylor, J.S.2
Beese, L.S.3
-
50
-
-
0032518524
-
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
-
Kiefer J.R., Mao C., Braman J.C., Beese L.S. Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature 1998, 391:304-307.
-
(1998)
Nature
, vol.391
, pp. 304-307
-
-
Kiefer, J.R.1
Mao, C.2
Braman, J.C.3
Beese, L.S.4
-
51
-
-
0032535528
-
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation
-
Li Y., Korolev S., Waksman G. Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. EMBO J. 1998, 17:7514-7525.
-
(1998)
EMBO J.
, vol.17
, pp. 7514-7525
-
-
Li, Y.1
Korolev, S.2
Waksman, G.3
-
52
-
-
1642276330
-
Structural basis for substrate selection by t7 RNA polymerase
-
Temiakov D., Patlan V., Anikin M., McAllister W.T., Yokoyama S., Vassylyev D.G. Structural basis for substrate selection by t7 RNA polymerase. Cell 2004, 116:381-391.
-
(2004)
Cell
, vol.116
, pp. 381-391
-
-
Temiakov, D.1
Patlan, V.2
Anikin, M.3
McAllister, W.T.4
Yokoyama, S.5
Vassylyev, D.G.6
-
53
-
-
0037112082
-
Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase
-
Yin Y.W., Steitz T.A. Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase. Science 2002, 298:1387-1395.
-
(2002)
Science
, vol.298
, pp. 1387-1395
-
-
Yin, Y.W.1
Steitz, T.A.2
-
54
-
-
1342313235
-
The structural mechanism of translocation and helicase activity in T7 RNA polymerase
-
Yin Y.W., Steitz T.A. The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell 2004, 116:393-404.
-
(2004)
Cell
, vol.116
, pp. 393-404
-
-
Yin, Y.W.1
Steitz, T.A.2
-
55
-
-
59649110607
-
Nucleic acid polymerases use a general acid for nucleotidyl transfer
-
Castro C., Smidansky E.D., Arnold J.J., Maksimchuk K.R., Moustafa I., Uchida A., Gotte M., Konigsberg W., Cameron C.E. Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat. Struct. Mol. Biol. 2009, 16:212-218.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 212-218
-
-
Castro, C.1
Smidansky, E.D.2
Arnold, J.J.3
Maksimchuk, K.R.4
Moustafa, I.5
Uchida, A.6
Gotte, M.7
Konigsberg, W.8
Cameron, C.E.9
-
56
-
-
33747621427
-
Visualizing polynucleotide polymerase machines at work
-
Steitz T.A. Visualizing polynucleotide polymerase machines at work. EMBO J. 2006, 25:3458-3468.
-
(2006)
EMBO J.
, vol.25
, pp. 3458-3468
-
-
Steitz, T.A.1
-
57
-
-
70549112913
-
The structural changes of T7 RNA polymerase from transcription initiation to elongation
-
Steitz T.A. The structural changes of T7 RNA polymerase from transcription initiation to elongation. Curr. Opin. Struct. Biol. 2009, 19:683-690.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 683-690
-
-
Steitz, T.A.1
-
58
-
-
0033529089
-
Structural basis for initiation of transcription from an RNA polymerase-promoter complex
-
Cheetham G.M., Jeruzalmi D., Steitz T.A. Structural basis for initiation of transcription from an RNA polymerase-promoter complex. Nature 1999, 399:80-83.
-
(1999)
Nature
, vol.399
, pp. 80-83
-
-
Cheetham, G.M.1
Jeruzalmi, D.2
Steitz, T.A.3
-
59
-
-
7244232840
-
Intrinsic promoter recognition by a "core" RNA polymerase
-
Matsunaga M., Jaehning J.A. Intrinsic promoter recognition by a "core" RNA polymerase. J. Biol. Chem. 2004, 279:44239-44242.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44239-44242
-
-
Matsunaga, M.1
Jaehning, J.A.2
-
60
-
-
67649412013
-
A promoter recognition mechanism common to yeast mitochondrial and phage t7 RNA polymerases
-
Nayak D., Guo Q., Sousa R. A promoter recognition mechanism common to yeast mitochondrial and phage t7 RNA polymerases. J. Biol. Chem. 2009, 284:13641-13647.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13641-13647
-
-
Nayak, D.1
Guo, Q.2
Sousa, R.3
-
61
-
-
10644229290
-
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells
-
Gaspari M., Falkenberg M., Larsson N.G., Gustafsson C.M. The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. EMBO J. 2004, 23:4606-4614.
-
(2004)
EMBO J.
, vol.23
, pp. 4606-4614
-
-
Gaspari, M.1
Falkenberg, M.2
Larsson, N.G.3
Gustafsson, C.M.4
-
62
-
-
0035799356
-
The T7 RNA polymerase intercalating hairpin is important for promoter opening during initiation but not for RNA displacement or transcription bubble stability during elongation
-
Brieba L.G., Sousa R. The T7 RNA polymerase intercalating hairpin is important for promoter opening during initiation but not for RNA displacement or transcription bubble stability during elongation. Biochemistry 2001, 40:3882-3890.
-
(2001)
Biochemistry
, vol.40
, pp. 3882-3890
-
-
Brieba, L.G.1
Sousa, R.2
-
63
-
-
0036308760
-
The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis
-
Stano N.M., Patel S.S. The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis. J. Mol. Biol. 2002, 315:1009-1025.
-
(2002)
J. Mol. Biol.
, vol.315
, pp. 1009-1025
-
-
Stano, N.M.1
Patel, S.S.2
-
64
-
-
74049123624
-
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication
-
Fuste J.M., Wanrooij S., Jemt E., Granycome C.E., Cluett T.J., Shi Y., Atanassova N., Holt I.J., Gustafsson C.M., Falkenberg M. Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol. Cell 2010, 37:67-78.
-
(2010)
Mol. Cell
, vol.37
, pp. 67-78
-
-
Fuste, J.M.1
Wanrooij, S.2
Jemt, E.3
Granycome, C.E.4
Cluett, T.J.5
Shi, Y.6
Atanassova, N.7
Holt, I.J.8
Gustafsson, C.M.9
Falkenberg, M.10
-
65
-
-
79955542547
-
The N-terminal domain of the yeast mitochondrial RNA polymerase regulates multiple steps of transcription
-
Paratkar S., Deshpande A.P., Tang G.Q., Patel S.S. The N-terminal domain of the yeast mitochondrial RNA polymerase regulates multiple steps of transcription. J. Biol. Chem. 2011, 286:16109-16120.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16109-16120
-
-
Paratkar, S.1
Deshpande, A.P.2
Tang, G.Q.3
Patel, S.S.4
-
66
-
-
0033529190
-
Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase
-
Wang Y., Shadel G.S. Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:8046-8051.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 8046-8051
-
-
Wang, Y.1
Shadel, G.S.2
-
67
-
-
0035896652
-
Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase
-
Rodeheffer M.S., Boone B.E., Bryan A.C., Shadel G.S. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J. Biol. Chem. 2001, 276:8616-8622.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8616-8622
-
-
Rodeheffer, M.S.1
Boone, B.E.2
Bryan, A.C.3
Shadel, G.S.4
-
68
-
-
0038043207
-
Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis
-
Rodeheffer M.S., Shadel G.S. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J. Biol. Chem. 2003, 278:18695-18701.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18695-18701
-
-
Rodeheffer, M.S.1
Shadel, G.S.2
-
69
-
-
4444268726
-
Coupling the mitochondrial transcription machinery to human disease
-
Shadel G.S. Coupling the mitochondrial transcription machinery to human disease. Trends Genet. 2004, 20:513-519.
-
(2004)
Trends Genet.
, vol.20
, pp. 513-519
-
-
Shadel, G.S.1
-
70
-
-
56049084211
-
PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression
-
Lightowlers R.N., Chrzanowska-Lightowlers Z.M. PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression. Biochem. J. 2008, 416:e5-e6.
-
(2008)
Biochem. J.
, vol.416
-
-
Lightowlers, R.N.1
Chrzanowska-Lightowlers, Z.M.2
-
71
-
-
0033965922
-
The PPR motif - a TPR-related motif prevalent in plant organellar proteins
-
Small I.D., Peeters N. The PPR motif - a TPR-related motif prevalent in plant organellar proteins. Trends Biochem. Sci. 2000, 25:46-47.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 46-47
-
-
Small, I.D.1
Peeters, N.2
-
72
-
-
0027411261
-
DNA-dependent and RNA-dependent DNA-polymerases
-
Steitz T.A. DNA-dependent and RNA-dependent DNA-polymerases. Curr. Opin. Struct. Biol. 1993, 3:31-38.
-
(1993)
Curr. Opin. Struct. Biol.
, vol.3
, pp. 31-38
-
-
Steitz, T.A.1
-
73
-
-
84961974064
-
Computer simulation of the chemical catalysis of DNA polymerases: discriminating between alternative nucleotide insertion mechanisms for T7 DNA polymerase
-
Florian J., Goodman M.F., Warshel A. Computer simulation of the chemical catalysis of DNA polymerases: discriminating between alternative nucleotide insertion mechanisms for T7 DNA polymerase. J. Am. Chem. Soc. 2003, 125:8163-8177.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8163-8177
-
-
Florian, J.1
Goodman, M.F.2
Warshel, A.3
-
74
-
-
11844283982
-
Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective
-
Castro C., Arnold J.J., Cameron C.E. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 2005, 107:141-149.
-
(2005)
Virus Res.
, vol.107
, pp. 141-149
-
-
Castro, C.1
Arnold, J.J.2
Cameron, C.E.3
-
75
-
-
0027220197
-
Conformational coupling in DNA polymerase fidelity
-
Johnson K.A. Conformational coupling in DNA polymerase fidelity. Annu. Rev. Biochem. 1993, 62:685-713.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 685-713
-
-
Johnson, K.A.1
-
76
-
-
77949570420
-
The kinetic and chemical mechanism of high-fidelity DNA polymerases
-
Johnson K.A. The kinetic and chemical mechanism of high-fidelity DNA polymerases. Biochim. Biophys. Acta 2010, 1804:1041-1048.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1041-1048
-
-
Johnson, K.A.1
-
77
-
-
8544278025
-
DNA polymerase fidelity: kinetics, structure, and checkpoints
-
Joyce C.M., Benkovic S.J. DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry 2004, 43:14317-14324.
-
(2004)
Biochemistry
, vol.43
, pp. 14317-14324
-
-
Joyce, C.M.1
Benkovic, S.J.2
-
78
-
-
40649100793
-
Structure-function relationships among RNA-dependent RNA polymerases
-
Ng K.K., Arnold J.J., Cameron C.E. Structure-function relationships among RNA-dependent RNA polymerases. Curr. Top. Microbiol. Immunol. 2008, 320:137-156.
-
(2008)
Curr. Top. Microbiol. Immunol.
, vol.320
, pp. 137-156
-
-
Ng, K.K.1
Arnold, J.J.2
Cameron, C.E.3
-
79
-
-
0037183526
-
A reexamination of the nucleotide incorporation fidelity of DNA polymerases
-
Showalter A.K., Tsai M.D. A reexamination of the nucleotide incorporation fidelity of DNA polymerases. Biochemistry 2002, 41:10571-10576.
-
(2002)
Biochemistry
, vol.41
, pp. 10571-10576
-
-
Showalter, A.K.1
Tsai, M.D.2
-
80
-
-
2442461170
-
Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection
-
Gohara D.W., Arnold J.J., Cameron C.E. Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry 2004, 43:5149-5158.
-
(2004)
Biochemistry
, vol.43
, pp. 5149-5158
-
-
Gohara, D.W.1
Arnold, J.J.2
Cameron, C.E.3
-
81
-
-
79958053065
-
Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds
-
Smidansky E.D., Arnold J.J., Reynolds S.L., Cameron C.E. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry 2011, 50:5016-5032.
-
(2011)
Biochemistry
, vol.50
, pp. 5016-5032
-
-
Smidansky, E.D.1
Arnold, J.J.2
Reynolds, S.L.3
Cameron, C.E.4
-
82
-
-
0037033076
-
Characterization of T7 RNA polymerase transcription complexes assembled on nucleic acid scaffolds
-
Temiakov D., Anikin M., McAllister W.T. Characterization of T7 RNA polymerase transcription complexes assembled on nucleic acid scaffolds. J. Biol. Chem. 2002, 277:47035-47043.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47035-47043
-
-
Temiakov, D.1
Anikin, M.2
McAllister, W.T.3
-
83
-
-
34248349170
-
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
-
Castro C., Smidansky E., Maksimchuk K.R., Arnold J.J., Korneeva V.S., Gotte M., Konigsberg W., Cameron C.E. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:4267-4272.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 4267-4272
-
-
Castro, C.1
Smidansky, E.2
Maksimchuk, K.R.3
Arnold, J.J.4
Korneeva, V.S.5
Gotte, M.6
Konigsberg, W.7
Cameron, C.E.8
-
84
-
-
78650864353
-
Fluorescence-based assay to measure the real-time kinetics of nucleotide incorporation during transcription elongation
-
Tang G.Q., Anand V.S., Patel S.S. Fluorescence-based assay to measure the real-time kinetics of nucleotide incorporation during transcription elongation. J. Mol. Biol. 2010, 405:666-678.
-
(2010)
J. Mol. Biol.
, vol.405
, pp. 666-678
-
-
Tang, G.Q.1
Anand, V.S.2
Patel, S.S.3
-
86
-
-
0030854581
-
Mechanism of ribose 2'-group discrimination by an RNA polymerase
-
Huang Y., Eckstein F., Padilla R., Sousa R. Mechanism of ribose 2'-group discrimination by an RNA polymerase. Biochemistry 1997, 36:8231-8242.
-
(1997)
Biochemistry
, vol.36
, pp. 8231-8242
-
-
Huang, Y.1
Eckstein, F.2
Padilla, R.3
Sousa, R.4
-
87
-
-
70549111391
-
RNA polymerase fidelity and transcriptional proofreading
-
Sydow J.F., Cramer P. RNA polymerase fidelity and transcriptional proofreading. Curr. Opin. Struct. Biol. 2009, 19:732-739.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 732-739
-
-
Sydow, J.F.1
Cramer, P.2
-
88
-
-
77951973031
-
Stepwise mechanism for transcription fidelity
-
Yuzenkova Y., Bochkareva A., Tadigotla V.R., Roghanian M., Zorov S., Severinov K., Zenkin N. Stepwise mechanism for transcription fidelity. BMC Biol. 2010, 8:54.
-
(2010)
BMC Biol.
, vol.8
, pp. 54
-
-
Yuzenkova, Y.1
Bochkareva, A.2
Tadigotla, V.R.3
Roghanian, M.4
Zorov, S.5
Severinov, K.6
Zenkin, N.7
-
89
-
-
0043073110
-
A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia
-
Deschauer M., Kiefer R., Blakely E.L., He L., Zierz S., Turnbull D.M., Taylor R.W. A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia. Neuromuscul. Disord. 2003, 13:568-572.
-
(2003)
Neuromuscul. Disord.
, vol.13
, pp. 568-572
-
-
Deschauer, M.1
Kiefer, R.2
Blakely, E.L.3
He, L.4
Zierz, S.5
Turnbull, D.M.6
Taylor, R.W.7
-
90
-
-
19444380425
-
Nuclear genes and mitochondrial translation: a new class of genetic disease
-
Jacobs H.T., Turnbull D.M. Nuclear genes and mitochondrial translation: a new class of genetic disease. Trends Genet. 2005, 21:312-314.
-
(2005)
Trends Genet.
, vol.21
, pp. 312-314
-
-
Jacobs, H.T.1
Turnbull, D.M.2
-
91
-
-
23644449234
-
Consequences of mutations in human DNA polymerase gamma
-
Longley M.J., Graziewicz M.A., Bienstock R.J., Copeland W.C. Consequences of mutations in human DNA polymerase gamma. Gene 2005, 354:125-131.
-
(2005)
Gene
, vol.354
, pp. 125-131
-
-
Longley, M.J.1
Graziewicz, M.A.2
Bienstock, R.J.3
Copeland, W.C.4
-
92
-
-
0037458031
-
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
-
Mootha V.K., Lepage P., Miller K., Bunkenborg J., Reich M., Hjerrild M., Delmonte T., Villeneuve A., Sladek R., Xu F., Mitchell G.A., Morin C., Mann M., Hudson T.J., Robinson B., Rioux J.D., Lander E.S. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:605-610.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 605-610
-
-
Mootha, V.K.1
Lepage, P.2
Miller, K.3
Bunkenborg, J.4
Reich, M.5
Hjerrild, M.6
Delmonte, T.7
Villeneuve, A.8
Sladek, R.9
Xu, F.10
Mitchell, G.A.11
Morin, C.12
Mann, M.13
Hudson, T.J.14
Robinson, B.15
Rioux, J.D.16
Lander, E.S.17
-
93
-
-
77953811054
-
The human mitochondrial replication fork in health and disease
-
Wanrooij S., Falkenberg M. The human mitochondrial replication fork in health and disease. Biochim. Biophys. Acta 2010, 1797:1378-1388.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1378-1388
-
-
Wanrooij, S.1
Falkenberg, M.2
-
94
-
-
45849132031
-
Mitochondrial off targets of drug therapy
-
Wallace K.B. Mitochondrial off targets of drug therapy. Trends Pharmacol. Sci. 2008, 29:361-366.
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, pp. 361-366
-
-
Wallace, K.B.1
-
95
-
-
33845744837
-
Initiation and beyond: multiple functions of the human mitochondrial transcription machinery
-
Bonawitz N.D., Clayton D.A., Shadel G.S. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol. Cell 2006, 24:813-825.
-
(2006)
Mol. Cell
, vol.24
, pp. 813-825
-
-
Bonawitz, N.D.1
Clayton, D.A.2
Shadel, G.S.3
-
96
-
-
78649839856
-
Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG
-
Cline S.D., Lodeiro M.F., Marnett L.J., Cameron C.E., Arnold J.J. Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG. Nucleic Acids Res. 2010, 38:7546-7557.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7546-7557
-
-
Cline, S.D.1
Lodeiro, M.F.2
Marnett, L.J.3
Cameron, C.E.4
Arnold, J.J.5
-
97
-
-
79952814524
-
Microcin J25-Ga induces apoptosis in mammalian cells by inhibiting mitochondrial RNA-polymerase
-
Niklison-Chirou M.V., Dupuy F., Saavedra L., Hebert E., Banchio C., Minahk C., Morero R.D. Microcin J25-Ga induces apoptosis in mammalian cells by inhibiting mitochondrial RNA-polymerase. Peptides 2011, 32:832-834.
-
(2011)
Peptides
, vol.32
, pp. 832-834
-
-
Niklison-Chirou, M.V.1
Dupuy, F.2
Saavedra, L.3
Hebert, E.4
Banchio, C.5
Minahk, C.6
Morero, R.D.7
-
98
-
-
84864319725
-
The human mitochondrial RNA polymerase as an off target for antiviral ribonucleosides
-
Arnold J.J., Smidansky E.D., Reynolds S., Cameron C.E. The human mitochondrial RNA polymerase as an off target for antiviral ribonucleosides. Mitochondrion 2010, 10:206.
-
(2010)
Mitochondrion
, vol.10
, pp. 206
-
-
Arnold, J.J.1
Smidansky, E.D.2
Reynolds, S.3
Cameron, C.E.4
-
99
-
-
77949570710
-
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease
-
Bailey C.M., Anderson K.S. A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease. Biochim. Biophys. Acta 2010, 1804:1213-1222.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1213-1222
-
-
Bailey, C.M.1
Anderson, K.S.2
-
100
-
-
0346995096
-
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase
-
Lee H., Hanes J., Johnson K.A. Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase. Biochemistry 2003, 42:14711-14719.
-
(2003)
Biochemistry
, vol.42
, pp. 14711-14719
-
-
Lee, H.1
Hanes, J.2
Johnson, K.A.3
-
101
-
-
0242363266
-
Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective
-
Lewis W., Day B.J., Copeland W.C. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat. Rev. Drug Discov. 2003, 2:812-822.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 812-822
-
-
Lewis, W.1
Day, B.J.2
Copeland, W.C.3
-
102
-
-
77955272829
-
A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma
-
Anderson K.S. A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma. Methods 2010, 51:392-398.
-
(2010)
Methods
, vol.51
, pp. 392-398
-
-
Anderson, K.S.1
-
103
-
-
67649625180
-
Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: nucleoside analogues
-
Brown N.A. Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: nucleoside analogues. Expert Opin. Investig. Drugs 2009, 18:709-725.
-
(2009)
Expert Opin. Investig. Drugs
, vol.18
, pp. 709-725
-
-
Brown, N.A.1
-
104
-
-
62949195680
-
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees
-
Carroll S.S., Ludmerer S., Handt L., Koeplinger K., Zhang N.R., Graham D., Davies M.E., MacCoss M., Hazuda D., Olsen D.B. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob. Agents Chemother. 2009, 53:926-934.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 926-934
-
-
Carroll, S.S.1
Ludmerer, S.2
Handt, L.3
Koeplinger, K.4
Zhang, N.R.5
Graham, D.6
Davies, M.E.7
MacCoss, M.8
Hazuda, D.9
Olsen, D.B.10
-
105
-
-
33645232568
-
The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture
-
Klumpp K., Leveque V., Le Pogam S., Ma H., Jiang W.R., Kang H., Granycome C., Singer M., Laxton C., Hang J.Q., Sarma K., Smith D.B., Heindl D., Hobbs C.J., Merrett J.H., Symons J., Cammack N., Martin J.A., Devos R., Najera I. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J. Biol. Chem. 2006, 281:3793-3799.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 3793-3799
-
-
Klumpp, K.1
Leveque, V.2
Le Pogam, S.3
Ma, H.4
Jiang, W.R.5
Kang, H.6
Granycome, C.7
Singer, M.8
Laxton, C.9
Hang, J.Q.10
Sarma, K.11
Smith, D.B.12
Heindl, D.13
Hobbs, C.J.14
Merrett, J.H.15
Symons, J.16
Cammack, N.17
Martin, J.A.18
Devos, R.19
Najera, I.20
more..
-
106
-
-
77953207214
-
Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy
-
Lange C.M., Sarrazin C., Zeuzem S. Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy. Aliment. Pharmacol. Ther. 2010, 32:14-28.
-
(2010)
Aliment. Pharmacol. Ther.
, vol.32
, pp. 14-28
-
-
Lange, C.M.1
Sarrazin, C.2
Zeuzem, S.3
-
107
-
-
20944435839
-
Inhibitory effect of 2'-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells
-
Tomassini J.E., Getty K., Stahlhut M.W., Shim S., Bhat B., Eldrup A.B., Prakash T.P., Carroll S.S., Flores O., MacCoss M., McMasters D.R., Migliaccio G., Olsen D.B. Inhibitory effect of 2'-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells. Antimicrob. Agents Chemother. 2005, 49:2050-2058.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 2050-2058
-
-
Tomassini, J.E.1
Getty, K.2
Stahlhut, M.W.3
Shim, S.4
Bhat, B.5
Eldrup, A.B.6
Prakash, T.P.7
Carroll, S.S.8
Flores, O.9
MacCoss, M.10
McMasters, D.R.11
Migliaccio, G.12
Olsen, D.B.13
-
108
-
-
84856410313
-
Antiviral strategies in hepatitis C virus infection
-
Sarrazin C., Hezode C., Zeuzem S., Pawlotsky J.M. Antiviral strategies in hepatitis C virus infection. J. Hepatol. 2012, 56(Suppl. 1):S88-S100.
-
(2012)
J. Hepatol.
, vol.56
, Issue.SUPPL. 1
-
-
Sarrazin, C.1
Hezode, C.2
Zeuzem, S.3
Pawlotsky, J.M.4
-
110
-
-
0035956859
-
The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals
-
Dolce V., Fiermonte G., Runswick M.J., Palmieri F., Walker J.E. The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:2284-2288.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 2284-2288
-
-
Dolce, V.1
Fiermonte, G.2
Runswick, M.J.3
Palmieri, F.4
Walker, J.E.5
-
111
-
-
1042301403
-
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs
-
Lai Y., Tse C.M., Unadkat J.D. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. J. Biol. Chem. 2004, 279:4490-4497.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4490-4497
-
-
Lai, Y.1
Tse, C.M.2
Unadkat, J.D.3
-
112
-
-
85047685868
-
The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity
-
Leung G.P., Tse C.M. The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity. Expert Opin. Drug Metab. Toxicol. 2007, 3:705-718.
-
(2007)
Expert Opin. Drug Metab. Toxicol.
, vol.3
, pp. 705-718
-
-
Leung, G.P.1
Tse, C.M.2
-
113
-
-
34547104596
-
The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic
-
Scatena R., Bottoni P., Botta G., Martorana G.E., Giardina B. The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic. Am. J. Physiol. Cell Physiol. 2007, 293:C12-C21.
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.293
-
-
Scatena, R.1
Bottoni, P.2
Botta, G.3
Martorana, G.E.4
Giardina, B.5
-
114
-
-
79955772655
-
Nucleoside triphosphate pool asymmetry in mammalian mitochondria
-
Wheeler L.J., Mathews C.K. Nucleoside triphosphate pool asymmetry in mammalian mitochondria. J. Biol. Chem. 2011, 286:16992-16996.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16992-16996
-
-
Wheeler, L.J.1
Mathews, C.K.2
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