A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase γ

Methods

Volumn 51, Issue 4, 2010, Pages 392-398

  Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AIDS drugs; HIV reverse transcriptase; Mitochondrial DNA polymerase gamma; NRTI; Nucleoside analogs; Rapid chemical quench; Transient kinetics

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; NUCLEOTIDYLTRANSFERASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CORRELATION COEFFICIENT; DISSOCIATION CONSTANT; DNA REPLICATION; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KINETICS; LONG TERM CARE; METHODOLOGY; MITOCHONDRIAL TOXICITY; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOGENOMICS; POLYMERIZATION; PRIORITY JOURNAL; RAPID CHEMICAL QUENCH; REVIEW; STEADY STATE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HIV REVERSE TRANSCRIPTASE; HUMANS; KINETICS; MODELS, BIOLOGICAL; NUCLEOSIDES; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77955272829     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2010.05.001     Document Type: Review

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