Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23

Immunogenetics

Volumn 64, Issue 7, 2012, Pages 481-496

  Duvvuri, Bhargavi ^a   Duvvuri, Venkata R ^b,c,d   Wu, Jianhong ^b   Wu, Gillian E ^a  

^a York University   (Canada)

^b YORK UNIVERSITY   (Canada)

^c PUBLIC HEALTH ONTARIO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Activationinduced cytidine deaminase (AID); DNA secondary structures; IGHV3 23; Negatively supercoiled region; RNA polymerase II stalling; Somatic hypermutation (SHM); Transcription

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; RNA POLYMERASE II; SINGLE STRANDED DNA;

ARTICLE; DNA STRAND; DNA STRUCTURE; DNA SUPERCOILING; GENE; GENETIC TRANSCRIPTION; IGHV3 23 GENE; PRIORITY JOURNAL; SOMATIC HYPERMUTATION;

BASE SEQUENCE; CYTIDINE DEAMINASE; DNA; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA POLYMERASE II; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTION, GENETIC;

EID: 84864279737     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-012-0607-3     Document Type: Article

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