I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation

Molecular Immunology

Volumn 45, Issue 13, 2008, Pages 3589-3599

  Wright, Barbara E ^a   Schmidt, Karen H ^a   Minnick, Michael F ^a   Davis, Nick ^a  

^a UNIVERSITY OF MONTANA   (United States)

Author keywords

Secondary structures; Somatic hypermutation; Supercoiling; Transcription directed mutagenesis

Indexed keywords

SINGLE STRANDED DNA;

ADAPTIVE IMMUNITY; ANTIBODY AFFINITY; ARTICLE; BASE PAIRING; COMPUTER PROGRAM; DNA SECONDARY STRUCTURE; DNA STRUCTURE; GENE; GENETIC TRANSCRIPTION; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIMULATION; SOMATIC HYPERMUTATION; VH5 GENE;

ANIMALS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; DNA; GENE FREQUENCY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN HEAVY CHAIN; MICE; MODELS, THEORETICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTION, GENETIC;

EID: 46749122571     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.02.030     Document Type: Article

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