Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6294-6305

  Karstad, Rasmus ^a   Isaksen, Geir ^a   Wynendaele, Evelien ^b   Guttormsen, Yngve ^a   De Spiegeleer, Bart ^b   Brandsdal, Bjørn Olav ^a   Svendsen, John Sigurd ^a   Svenson, Johan ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO (3 GUANIDINO)PROPANOIC ACID; AMINO ACID DERIVATIVE; CATION; GUANIDINE DERIVATIVE; HOMOARGININE; POLYPEPTIDE ANTIBIOTIC AGENT; PROPIONIC ACID DERIVATIVE; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; DUODENUM; ENZYME ACTIVE SITE; ISOTHERMAL TITRATION CALORIMETRY; MALE; MATHEMATICAL COMPUTING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN STABILITY; STAPHYLOCOCCUS AUREUS; STOICHIOMETRY; STOMACH; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DRUG DESIGN; DRUG STABILITY; HALF-LIFE; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEOLYSIS; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY; TRYPSIN;

EID: 84864234559     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3002058     Document Type: Article

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