The role of conserved glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring glu to asp mutant

Biochemistry

Volumn 50, Issue 19, 2011, Pages 4077-4086

  Wang, Conan K L ^a   Clark, Richard J ^a   Harvey, Peta J ^a   Johan Rosengren, K ^a   Cemazar, Masa ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV ACTIVITY; ASPARTATES; ASPARTIC ACIDS; CHEMICAL CONDITIONS; CONSERVED RESIDUES; CYCLOTIDES; GLUTAMIC ACID; KALATA B1; NATURALLY OCCURRING; OXIDATIVE FOLDING; PLANT DEFENSE; PROTEIN DRUGS; STRUCTURAL FEATURE;

ALKYLATION; AMINO ACIDS; BIOACTIVITY; HYDROGEN BONDS; PROTEINS; SCAFFOLDS (BIOLOGY); STABILITY;

CHEMICAL STABILITY;

ALANINE; ASPARTIC ACID; CYCLOTIDE; GLUTAMIC ACID; KALATA B12; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVITY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MEMBRANE DAMAGE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; THERMOSTABILITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ASPARTIC ACID; CONSERVED SEQUENCE; CYCLOTIDES; GLUTAMIC ACID; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RUBIACEAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955799325     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2004153     Document Type: Article

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