Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides

Journal of Medicinal Chemistry

Volumn 47, Issue 17, 2004, Pages 4159-4162

  Haug, Bengt Erik ^a   Stensen, Wenche ^a   Stiberg, Trine ^a   Svendsen, John S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTIINFECTIVE AGENT; CATION; CATIONIC ANTIBACTERIAL PEPTIDE; PEPTIDE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG DESIGN; DRUG SCREENING; GENETIC CODE; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; CATIONS; DIPEPTIDES; DRUG DESIGN; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS;

EID: 3843109179     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049582b     Document Type: Article

References (22)

1. Neu, H. C. The crisis in antibiotic resistance. Science 1992, 257, 1064-1073.
2. Internal Task Force. Antimicrobial Resistance: A Public Health Action Plan to Combat Antimicrobial Resistance; CDC: Atlanta, GA, 2001; pp 1-46.
3. Bren, L. Battle of the Bugs: Fighting Antibiotic Resistance. FDA Consum. 2002, 36, 28-34.
4. Gold, H. S.; Moellering, R. C. Antimicrobial-drug resistance. N. Engl. J. Med. 1996, 335, 144-1453.
5. Levy, S. B. The challenge of antibiotic resistance. Sci. Am. 1998, 275, 46-53.
6. Levy, S. B. Multidrug resistance - a sign of the times. N. Engl. J. Med. 1998, 338, 1376-1378.
7. Walsh, C. Molecular mechanisms that confer antibacterial drug resistance. Nature 2000, 406, 775-781.
8. Steiner, H.; Hultmark, D.; Engström, Å.; Bennich, H.; Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981, 292, 246-248.
9. Diamond, G. Nature's antibiotics - the potential of antimicrobial peptides as new drugs. Biologist 2001, 48, 209-212.
10. Hancock, R. E. W. Host Defence (Cationic) Peptides. What Is Their Future Clinic Potential? Drugs 1999, 57, 469-473.
11. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389-395.
12. Haug, B. E.; Svendsen, J. S. The role of tryptophan in the antibacterial activity of a 15-residue bovine lactoferricin peptide. J. Pept. Sci. 2001, 7, 190-196.
13. Haug, B. E.; Skar, M. L.; Svendsen, J. S. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives. J. Pept. Sci. 2001, 7, 425-432.
14. Lejon, T.; Svendsen, J. S.; Haug, B. E. Simple Parameterisation of Non-proteinogenic Amino Acids for QSAR of Antibacterial Peptides. J. Pept. Sci. 2002, 8, 302-306.
15. Rekdal, Ø.; Andersen, J.; Vorland, L. H.; Svendsen, J. S. Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity. J. Pept. Sci. 1999, 5, 32-45.
16. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S. Antibacterial activity of 15-residue lactoferricin derivatives. J. Pept. Res. 2000, 56, 265-274.
17. Strøm, M. B.; Haug, B. E.; Rekdal, Ø.; Skar, M. L.; Stensen, W.; et al. Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity. Biochem. Cell Biol. 2002, 80, 65-74.
18. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S. The effects of charge and lipophilicity on the antibacterial activity of undecapeptides derived from bovine lactoferricin. J. Pept. Sci. 2002, 8, 36-43.
19. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S. Antimicrobial activity of short arginine- and tryptophan-rich peptides. J. Pept. Sci. 2002, 8, 431-437.
20. Strøm, M. B.; Haug, B. E.; Skar, M. L.; Stensen, W.; Stiberg, T.; et al. The pharmacophore of short cationic antibacterial peptides. J. Med. Chem. 2003, 46, 1567-1570.
21. Hancock, R. E. W. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect. Dis. 2001, 1, 156-164.
22. Fernandez-Lopez, S.; Kim, H.-S.; Choi, E. C.; Delgado, M.; Granja, J. R.; et al. Antibacterial agents based on the cyclic D,L-α-peptide architecture. Nature 2001, 412, 452-455.