-
1
-
-
33745107170
-
Strategies to improve plasma half life time of peptide and protein drugs
-
Werle, M., and Bernkop-Schnurch, A. (2006) Strategies to improve plasma half life time of peptide and protein drugs. Amino Acids 30, 351-367.
-
(2006)
Amino Acids
, vol.30
, pp. 351-367
-
-
Werle, M.1
Bernkop-Schnurch, A.2
-
2
-
-
0347547881
-
On proteolytic enzymes. X. The enzymes of papain and their activation
-
Bergmann, M., and Ross, W. F. (1936) On proteolytic enzymes. X. The enzymes of papain and their activation. J. Biol. Chem. 114, 717-726.
-
(1936)
J. Biol. Chem
, vol.114
, pp. 717-726
-
-
Bergmann, M.1
Ross, W.F.2
-
3
-
-
0034628448
-
Protease inhibitors: Current status and future prospects
-
Leung, D., Abbenante, G., and Fairlie, D. P. (2000) Protease inhibitors: Current status and future prospects. J. Med. Chem. 43, 305-341.
-
(2000)
J. Med. Chem
, vol.43
, pp. 305-341
-
-
Leung, D.1
Abbenante, G.2
Fairlie, D.P.3
-
4
-
-
0002676730
-
Inhibitors of serine proteinases
-
Barrett, A. J, and Salvesen, G, Eds, pp, Elsevier, Amsterdam
-
Powers, J. C., and Harper, J. W. (1986) Inhibitors of serine proteinases, in Proteinase Inhibitors (Barrett, A. J., and Salvesen, G., Eds.) pp 56-152, Elsevier, Amsterdam.
-
(1986)
Proteinase Inhibitors
, pp. 56-152
-
-
Powers, J.C.1
Harper, J.W.2
-
5
-
-
0032833799
-
Terminal modifications inhibit proteolytic degradation of an immunogenic MART-1(27-35) peptide: Implications for peptide vaccines
-
Brinckerhoff, L. H., Kalashnikov, V. V., Thompson, L. W., Yamshchikov, G. V., Pierce, R. A., Galavotti, H. S., Engelhard, V. H., and Slingluff, C. L. (1999) Terminal modifications inhibit proteolytic degradation of an immunogenic MART-1(27-35) peptide: Implications for peptide vaccines. Int. J. Cancer 83, 326-334.
-
(1999)
Int. J. Cancer
, vol.83
, pp. 326-334
-
-
Brinckerhoff, L.H.1
Kalashnikov, V.V.2
Thompson, L.W.3
Yamshchikov, G.V.4
Pierce, R.A.5
Galavotti, H.S.6
Engelhard, V.H.7
Slingluff, C.L.8
-
6
-
-
0029084673
-
Macrocyclic Peptidomimetics - Forcing Peptides into Bioactive Conformations
-
Fairlie, D. P., Abbenante, G., and March, D. R. (1995) Macrocyclic Peptidomimetics - Forcing Peptides into Bioactive Conformations. Curr. Med. Chem. 2, 654-686.
-
(1995)
Curr. Med. Chem
, vol.2
, pp. 654-686
-
-
Fairlie, D.P.1
Abbenante, G.2
March, D.R.3
-
7
-
-
11144336770
-
Synthetic preparation of N-methyl-alpha-amino acids
-
Aurelio, L., Brownlee, R. T. C., and Hughes, A. B. (2004) Synthetic preparation of N-methyl-alpha-amino acids. Chem. Rev. 104, 5823-5846.
-
(2004)
Chem. Rev
, vol.104
, pp. 5823-5846
-
-
Aurelio, L.1
Brownlee, R.T.C.2
Hughes, A.B.3
-
8
-
-
0028306217
-
Somatostatin and Somatostatin Analogs - Pharmacokinetics and Pharmacodynamic Effects
-
Harris, A. G. (1994) Somatostatin and Somatostatin Analogs - Pharmacokinetics and Pharmacodynamic Effects. Gut 35, 1-4.
-
(1994)
Gut
, vol.35
, pp. 1-4
-
-
Harris, A.G.1
-
9
-
-
0035144555
-
Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry
-
Braun, K., Kuhl, P., Bernd, M., and Kutscher, B. (2001) Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry. Pharmazie 56, 45-49.
-
(2001)
Pharmazie
, vol.56
, pp. 45-49
-
-
Braun, K.1
Kuhl, P.2
Bernd, M.3
Kutscher, B.4
-
10
-
-
0023686915
-
Dermorphin Analogs - Resistance to In vitro Enzymatic Degradation Is Not Always Increased by Additional D-Amino-Acid Substitutions
-
Darlak, K., Benovitz, D. E., Spatola, A. F., and Grzonka, Z. (1988) Dermorphin Analogs - Resistance to In vitro Enzymatic Degradation Is Not Always Increased by Additional D-Amino-Acid Substitutions. Biochem. Biophys. Res. Commun. 156, 125-130.
-
(1988)
Biochem. Biophys. Res. Commun
, vol.156
, pp. 125-130
-
-
Darlak, K.1
Benovitz, D.E.2
Spatola, A.F.3
Grzonka, Z.4
-
11
-
-
15644370832
-
Lanthionine-somatostatin analogs: Synthesis, characterization, biological activity, and enzymatic stability studies
-
Osapay, G., Prokai, L., Kim, H. S., Medzihradszky, K. F., Coy, D. H., Liapakis, G., Reisine, T., Melacini, G., Zhu, Q., Wang, S. H. H., Mattern, R. H., and Goodman, M. (1997) Lanthionine-somatostatin analogs: Synthesis, characterization, biological activity, and enzymatic stability studies. J. Med. Chem. 40, 2241-2251.
-
(1997)
J. Med. Chem
, vol.40
, pp. 2241-2251
-
-
Osapay, G.1
Prokai, L.2
Kim, H.S.3
Medzihradszky, K.F.4
Coy, D.H.5
Liapakis, G.6
Reisine, T.7
Melacini, G.8
Zhu, Q.9
Wang, S.H.H.10
Mattern, R.H.11
Goodman, M.12
-
12
-
-
0344198180
-
Structure-based design of an indolicidin peptide analogue with increased protease stability
-
Rozek, A., Powers, J. P. S., Friedrich, C. L., and Hancock, R. E. W. (2003) Structure-based design of an indolicidin peptide analogue with increased protease stability. Biochemistry 42, 14130-14138.
-
(2003)
Biochemistry
, vol.42
, pp. 14130-14138
-
-
Rozek, A.1
Powers, J.P.S.2
Friedrich, C.L.3
Hancock, R.E.W.4
-
13
-
-
5744242169
-
Development of conformationally restricted analogues of bradykinin and somatostatin using constrained amino acids and different types of cyclization
-
Reissmann, S., and Imhof, D. (2004) Development of conformationally restricted analogues of bradykinin and somatostatin using constrained amino acids and different types of cyclization. Curr. Med. Chem. 11, 2823-2844.
-
(2004)
Curr. Med. Chem
, vol.11
, pp. 2823-2844
-
-
Reissmann, S.1
Imhof, D.2
-
14
-
-
33646161254
-
Structure- and fragment-based approaches to protease inhibition
-
Johnson, S. L., and Pellecchia, M. (2006) Structure- and fragment-based approaches to protease inhibition. Curr. Top. Med. Chem. 6, 317-329.
-
(2006)
Curr. Top. Med. Chem
, vol.6
, pp. 317-329
-
-
Johnson, S.L.1
Pellecchia, M.2
-
15
-
-
27444439184
-
Selective inhibitors of the serine protease plasmin: Probing the S3 and S3′ subsites using a combinatorial library
-
Xue, F. T., and Seto, C. T. (2005) Selective inhibitors of the serine protease plasmin: Probing the S3 and S3′ subsites using a combinatorial library. J. Med. Chem. 48, 6908-6917.
-
(2005)
J. Med. Chem
, vol.48
, pp. 6908-6917
-
-
Xue, F.T.1
Seto, C.T.2
-
16
-
-
0017056107
-
Specificity of Trypsin and Alpha-Chymotrypsin Towards Neutral Substrates
-
Vajda, T., and Szabo, T. (1976) Specificity of Trypsin and Alpha-Chymotrypsin Towards Neutral Substrates. Acta Biochim. Biophys. Hung. 11, 287-294.
-
(1976)
Acta Biochim. Biophys. Hung
, vol.11
, pp. 287-294
-
-
Vajda, T.1
Szabo, T.2
-
17
-
-
33845699790
-
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
-
Hancock, R. E. W., and Sahl, H. G. (2006) Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24, 1551-1557.
-
(2006)
Nat. Biotechnol
, vol.24
, pp. 1551-1557
-
-
Hancock, R.E.W.1
Sahl, H.G.2
-
18
-
-
0037165196
-
Antimicrobial peptides of multicellular organisms
-
Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature 415, 389-395.
-
(2002)
Nature
, vol.415
, pp. 389-395
-
-
Zasloff, M.1
-
19
-
-
33748413776
-
Antibacterial peptides for therapeutic use: Obstacles and realistic outlook
-
Marr, A. K., Gooderham, W. J., and Hancock, R. E. W. (2006) Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr. Opin. Pharmacol. 6, 468-472.
-
(2006)
Curr. Opin. Pharmacol
, vol.6
, pp. 468-472
-
-
Marr, A.K.1
Gooderham, W.J.2
Hancock, R.E.W.3
-
20
-
-
0036765924
-
Evidence for a direct antitumor mechanism of action of bovine lactoferricin
-
Eliassen, L. T., Berge, G., Sveinbjornsson, B., Svendsen, J. S., Vorland, L. H., and Rekdal, O. (2002) Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Res. 22, 2703-2710.
-
(2002)
Anticancer Res
, vol.22
, pp. 2703-2710
-
-
Eliassen, L.T.1
Berge, G.2
Sveinbjornsson, B.3
Svendsen, J.S.4
Vorland, L.H.5
Rekdal, O.6
-
21
-
-
0344519712
-
The pharmacophore of short cationic antibacterial peptides
-
Strom, M. B., Haug, B. E., Skar, M. L., Stensen, W., Stiberg, T., and Svendsen, J. S. (2003) The pharmacophore of short cationic antibacterial peptides. J. Med. Chem. 46, 1567-1570.
-
(2003)
J. Med. Chem
, vol.46
, pp. 1567-1570
-
-
Strom, M.B.1
Haug, B.E.2
Skar, M.L.3
Stensen, W.4
Stiberg, T.5
Svendsen, J.S.6
-
22
-
-
3843109179
-
Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides
-
Haug, B. E., Stensen, W., Stiberg, T., and Svendsen, J. S. (2004) Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides. J. Med. Chem. 47, 4159-4162.
-
(2004)
J. Med. Chem
, vol.47
, pp. 4159-4162
-
-
Haug, B.E.1
Stensen, W.2
Stiberg, T.3
Svendsen, J.S.4
-
23
-
-
33845973364
-
The medicinal chemistry of short lactoferricin-based antibacterial peptides
-
Haug, B. E., Strom, M. B., and Svendsen, J. S. (2007) The medicinal chemistry of short lactoferricin-based antibacterial peptides. Curr. Med. Chem. 14, 1-18.
-
(2007)
Curr. Med. Chem
, vol.14
, pp. 1-18
-
-
Haug, B.E.1
Strom, M.B.2
Svendsen, J.S.3
-
24
-
-
0028133496
-
Converting Trypsin to Chymotrypsin - Residue-172 Is a Substrate-Specificity Determinant
-
Hedstrom, L., Perona, J. J., and Rutter, W. J. (1994) Converting Trypsin to Chymotrypsin - Residue-172 Is a Substrate-Specificity Determinant. Biochemistry 33, 8757-8763.
-
(1994)
Biochemistry
, vol.33
, pp. 8757-8763
-
-
Hedstrom, L.1
Perona, J.J.2
Rutter, W.J.3
-
25
-
-
0036882394
-
Serine protease mechanism and specificity
-
Hedstrom, L. (2002) Serine protease mechanism and specificity. Chem. Rev. 102, 4501-4523.
-
(2002)
Chem. Rev
, vol.102
, pp. 4501-4523
-
-
Hedstrom, L.1
-
26
-
-
0000749379
-
Coupling N-Methylated Amino-Acids Using Pybrop and Pyclop Halogenophosphonium Salts - Mechanism and Fields of Application
-
Coste, J., Frerot, E., and Jouin, P. (1994) Coupling N-Methylated Amino-Acids Using Pybrop and Pyclop Halogenophosphonium Salts - Mechanism and Fields of Application. J. Org. Chem. 59, 2437-2446.
-
(1994)
J. Org. Chem
, vol.59
, pp. 2437-2446
-
-
Coste, J.1
Frerot, E.2
Jouin, P.3
-
27
-
-
0018321807
-
Untersuchungen über den enzymatischen abbau von tert-butyltryptophan-haltigen peptides.
-
Sjago, M., and Löw, M. (1979) Untersuchungen über den enzymatischen abbau von tert-butyltryptophan-haltigen peptides. Hoppe-Seyler's Z. Phys. Chem. 360, 9-12.
-
(1979)
Hoppe-Seyler's Z. Phys. Chem
, vol.360
, pp. 9-12
-
-
Sjago, M.1
Löw, M.2
-
28
-
-
41149107738
-
-
http://www-users.med.cornell.edu/~spon/picu/calc/halfcalc.htm.
-
-
-
-
29
-
-
0001994881
-
Susceptibility testing of antimicrobials in liquid media
-
Lorian, V, Ed, 4th ed, pp, Williams and Wilkins, Baltimore, MD
-
Amsterdam, D. (1996) Susceptibility testing of antimicrobials in liquid media, in Antibiotics in Laboratory Medicine (Lorian, V., Ed.) 4th ed., pp 75-78, Williams and Wilkins, Baltimore, MD.
-
(1996)
Antibiotics in Laboratory Medicine
, pp. 75-78
-
-
Amsterdam, D.1
-
30
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
-
Morris, G. M., Goodsell, D. S., Halliday, R. S., Huey, R., Hart, W. E., Belew, R. K., and Olson, A. J. (1998) Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem. 19, 1639-1662.
-
(1998)
J. Comput. Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
Huey, R.4
Hart, W.E.5
Belew, R.K.6
Olson, A.J.7
-
31
-
-
84977303841
-
The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and Its Complexes with Inhibitors
-
Marquart, M., Walter, J., Deisenhofer, J., Bode, W., and Huber, R. (1983) The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and Its Complexes with Inhibitors. Acta Crystallogr. B 39, 480-490.
-
(1983)
Acta Crystallogr. B
, vol.39
, pp. 480-490
-
-
Marquart, M.1
Walter, J.2
Deisenhofer, J.3
Bode, W.4
Huber, R.5
-
32
-
-
0035875953
-
Electrostatic effects play a central role in cold adaptation of trypsin
-
Brandsdal, B. O., Smalas, A. O., and Aqvist, J. (2001) Electrostatic effects play a central role in cold adaptation of trypsin. FEBS Lett. 499, 171-175.
-
(2001)
FEBS Lett
, vol.499
, pp. 171-175
-
-
Brandsdal, B.O.1
Smalas, A.O.2
Aqvist, J.3
-
34
-
-
33947586139
-
Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials
-
Haug, B. E., Stensen, W., and Svendsen, J. S. (2007) Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials. Bioorg. Med. Chem. Lett. 17, 2361-2364.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 2361-2364
-
-
Haug, B.E.1
Stensen, W.2
Svendsen, J.S.3
-
35
-
-
0035442411
-
Direct measurement of protein binding energetics by isothermal titration calorimetry
-
Leavitt, S., and Freire, E. (2001) Direct measurement of protein binding energetics by isothermal titration calorimetry. Curr. Opin. Struct. Biol. 11, 560-566.
-
(2001)
Curr. Opin. Struct. Biol
, vol.11
, pp. 560-566
-
-
Leavitt, S.1
Freire, E.2
-
36
-
-
3543005385
-
Thermodynamics of protein-ligand interactions: History, presence, and future aspects
-
Perozzo, R., Folkers, G., and Scapozza, L. (2004) Thermodynamics of protein-ligand interactions: History, presence, and future aspects. J. Recept. Signal Transduction 24, 1-52.
-
(2004)
J. Recept. Signal Transduction
, vol.24
, pp. 1-52
-
-
Perozzo, R.1
Folkers, G.2
Scapozza, L.3
-
37
-
-
33845420956
-
Using proteinases for Edman sequence analysis and peptide mapping
-
Beynon, R, and Bond, J. S, Eds, pp, Oxford, New York
-
Shannon, J. (2001) Using proteinases for Edman sequence analysis and peptide mapping, in Proteolytic enzymes (Beynon, R., and Bond, J. S., Eds.) pp 187-210, Oxford, New York.
-
(2001)
Proteolytic enzymes
, pp. 187-210
-
-
Shannon, J.1
-
38
-
-
0030729481
-
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold
-
Perona, J. J., and Craik, C. S. (1997) Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J. Biol. Chem. 272, 29987-29990.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 29987-29990
-
-
Perona, J.J.1
Craik, C.S.2
-
39
-
-
0014211618
-
On Size of Active Site in Proteases. I. Papain
-
Schechter, I., and Berger, A. (1967) On Size of Active Site in Proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 157-162.
-
(1967)
Biochem. Biophys. Res. Commun
, vol.27
, pp. 157-162
-
-
Schechter, I.1
Berger, A.2
-
40
-
-
0026520387
-
Converting Trypsin to Chymotrypsin - the Role of Surface Loops
-
Hedstrom, L., Szilagyi, L., and Rutter, W. J. (1992) Converting Trypsin to Chymotrypsin - the Role of Surface Loops. Science 255, 1249-1253.
-
(1992)
Science
, vol.255
, pp. 1249-1253
-
-
Hedstrom, L.1
Szilagyi, L.2
Rutter, W.J.3
-
41
-
-
17244364283
-
Proteases universally recognize beta strands in their active sites
-
Tyndall, J. D. A., Nall, T., and Fairlie, D. P. (2005) Proteases universally recognize beta strands in their active sites. Chem. Rev. 105, 973-999.
-
(2005)
Chem. Rev
, vol.105
, pp. 973-999
-
-
Tyndall, J.D.A.1
Nall, T.2
Fairlie, D.P.3
-
42
-
-
0028914722
-
Structural Basis of Substrate-Specificity in the Serine Proteases
-
Perona, J. J., and Craik, C. S. (1995) Structural Basis of Substrate-Specificity in the Serine Proteases. Protein Sci. 4, 337-360.
-
(1995)
Protein Sci
, vol.4
, pp. 337-360
-
-
Perona, J.J.1
Craik, C.S.2
-
43
-
-
0025142492
-
Inhibition of Chymotrypsin by Peptidyl Trifluoromethyl Ketones - Determinants of Slow-Binding Kinetics
-
Brady, K., and Abeles, R. H. (1990) Inhibition of Chymotrypsin by Peptidyl Trifluoromethyl Ketones - Determinants of Slow-Binding Kinetics. Biochemistry 29, 7608-7617.
-
(1990)
Biochemistry
, vol.29
, pp. 7608-7617
-
-
Brady, K.1
Abeles, R.H.2
-
44
-
-
0034604364
-
Substitutions at the P-1′ position in BPTI strongly affect the association energy with serine proteinases
-
Grzesiak, A., Helland, R., Smalas, A. O., Krowarsch, D., Dadlez, M., and Otlewski, J. (2000) Substitutions at the P-1′ position in BPTI strongly affect the association energy with serine proteinases. J. Mol. Biol. 301, 205-217.
-
(2000)
J. Mol. Biol
, vol.301
, pp. 205-217
-
-
Grzesiak, A.1
Helland, R.2
Smalas, A.O.3
Krowarsch, D.4
Dadlez, M.5
Otlewski, J.6
-
45
-
-
1642389967
-
Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries
-
Reid, R. C., Pattenden, L. K., Tyndall, J. D. A., Martin, J. L., Walsh, T., and Fairlie, D. P. (2004) Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries. J. Med. Chem. 47, 1641-1651.
-
(2004)
J. Med. Chem
, vol.47
, pp. 1641-1651
-
-
Reid, R.C.1
Pattenden, L.K.2
Tyndall, J.D.A.3
Martin, J.L.4
Walsh, T.5
Fairlie, D.P.6
|