메뉴 건너뛰기




Volumn 397, Issue 4, 2012, Pages 507-512

Energy metabolism and proliferation in pancreatic carcinogenesis

Author keywords

Energy metabolism; Pancreatic carcinogenesis; Pancreatic ductal adenocarcinoma (PDAC)

Indexed keywords

GLUCOSE; GLUTAMINE; LACTIC ACID; PROTEIN KINASE LKB1; PYRUVIC ACID;

EID: 84863986550     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-012-0933-9     Document Type: Review
Times cited : (23)

References (62)
  • 1
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ et al (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7 (1):11-20
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • Deberardinis, R.J.1
  • 3
    • 84858002179 scopus 로고    scopus 로고
    • Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: A comparative study in transgenic mice and human tissues
    • doi: 10.1002/path.3017
    • Aichler M et al (2011) Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol doi: 10.1002/path.3017
    • (2011) J Pathol
    • Aichler, M.1
  • 4
    • 80051700067 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Vincent A et al (2011) Pancreatic cancer. Lancet 378(9791):607-620
    • (2011) Lancet , vol.378 , Issue.9791 , pp. 607-620
    • Vincent, A.1
  • 5
    • 0000459772 scopus 로고
    • Über den Stoffwechsel der Tumoren
    • Warburg O, Posener K, Negelein E (1924) Über den Stoffwechsel der Tumoren. Biochem Z 152:319-344
    • (1924) Biochem Z , vol.152 , pp. 319-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 7
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • DOI 10.1016/j.ccr.2006.04.023, PII S1535610806001450
    • Fantin VR, St-Pierre J, Leder P (2006) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9(6):425-434 (Pubitemid 43832190)
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 8
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A et al (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 107(5):2037-2042
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.5 , pp. 2037-2042
    • Le, A.1
  • 9
    • 70349307027 scopus 로고    scopus 로고
    • CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
    • Schneiderhan W et al (2009) CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. Gut 58(10):1391-1398
    • (2009) Gut , vol.58 , Issue.10 , pp. 1391-1398
    • Schneiderhan, W.1
  • 10
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330(6009):1340-1344
    • (2010) Science , vol.330 , Issue.6009 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 11
    • 84856655854 scopus 로고    scopus 로고
    • Proteomic analysis reveals warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells
    • Zhou Wet al (2012) Proteomic analysis reveals warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells. J Proteome Res 11(2):554-563
    • (2012) J Proteome Res , vol.11 , Issue.2 , pp. 554-563
    • Wet Al., Z.1
  • 12
    • 27644477840 scopus 로고    scopus 로고
    • Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells
    • DOI 10.1158/1078-0432.CCR-04-2530
    • Kwon SJ, Lee YJ (2005) Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clin Cancer Res: Off J Am Assoc Cancer Res 11 (13):4694-4700 (Pubitemid 41557187)
    • (2005) Clinical Cancer Research , vol.11 , Issue.13 , pp. 4694-4700
    • Kwon, S.J.1    Lee, Y.J.2
  • 13
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ et al (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104(49):19345-19350
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.49 , pp. 19345-19350
    • Deberardinis, R.J.1
  • 14
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11(5):325-337
    • (2011) Nat Rev Cancer , vol.11 , Issue.5 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 15
    • 79955755461 scopus 로고    scopus 로고
    • Inborn and acquired metabolic defects in cancer
    • Frezza C, Pollard PJ, Gottlieb E (2011) Inborn and acquired metabolic defects in cancer. J Mol Med 89(3):213-220
    • (2011) J Mol Med , vol.89 , Issue.3 , pp. 213-220
    • Frezza, C.1    Pollard, P.J.2    Gottlieb, E.3
  • 16
    • 0030988302 scopus 로고    scopus 로고
    • P16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk CA, Hruban RH, Kern SE (1997) p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 57(11):2140-2143 (Pubitemid 27247028)
    • (1997) Cancer Research , vol.57 , Issue.11 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 17
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA et al (2009) DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol: Off J Am Soc Clin Oncol 27 (11):1806-1813
    • (2009) J Clin Oncol: Off J Am Soc Clin Oncol , vol.27 , Issue.11 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1
  • 19
    • 80051866908 scopus 로고    scopus 로고
    • Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
    • Gaglio D et al (2011) Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol 7:523
    • (2011) Mol Syst Biol , vol.7 , pp. 523
    • Gaglio, D.1
  • 20
    • 70349331678 scopus 로고    scopus 로고
    • Glucose deprivation contributes to the development of KRAS pathwaymutations in tumor cells
    • Yun J et al (2009) Glucose deprivation contributes to the development of KRAS pathwaymutations in tumor cells. Science 325(5947):1555-1559
    • (2009) Science , vol.325 , Issue.5947 , pp. 1555-1559
    • Yun, J.1
  • 22
    • 33748305738 scopus 로고    scopus 로고
    • Ras-dependent carbon metabolism and transformation in mouse fibroblasts
    • DOI 10.1038/sj.onc.1209528, PII 1209528
    • Chiaradonna F et al (2006) Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Oncogene 25(39):5391-5404 (Pubitemid 44330282)
    • (2006) Oncogene , vol.25 , Issue.39 , pp. 5391-5404
    • Chiaradonna, F.1    Sacco, E.2    Manzoni, R.3    Giorgio, M.4    Vanoni, M.5    Alberghina, L.6
  • 23
    • 79956207689 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma and transcription factors: Role of c-Myc
    • Skoudy A, Hernandez-Munoz I, Navarro P (2011) Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc. J Gastrointest Cancer 42(2):76-84
    • (2011) J Gastrointest Cancer , vol.42 , Issue.2 , pp. 76-84
    • Skoudy, A.1    Hernandez-Munoz, I.2    Navarro, P.3
  • 24
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8(12):976-990
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 25
    • 0036229486 scopus 로고    scopus 로고
    • C-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance
    • DOI 10.1038/modpathol.3880547
    • Schleger C et al (2002) c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance. Mod Pathol 15(4):462-469 (Pubitemid 34326956)
    • (2002) Modern Pathology , vol.15 , Issue.4 , pp. 462-469
    • Schleger, C.1    Verbeke, C.2    Hildenbrand, R.3    Zentgraf, H.4    Bleyl, U.5
  • 26
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R et al (2000) Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14(19): 2501-2514
    • (2000) Genes Dev , vol.14 , Issue.19 , pp. 2501-2514
    • Sears, R.1
  • 27
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise DR et al (2008) Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 105(48):18782-18787
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.48 , pp. 18782-18787
    • Wise, D.R.1
  • 28
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P (2009) MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res: Off J Am Assoc Cancer Res 15(21):6479-6483
    • (2009) Clin Cancer Res: Off J Am Assoc Cancer Res , vol.15 , Issue.21 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 30
    • 0028268635 scopus 로고
    • K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
    • Pellegata NS et al (1994) K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 54(6):1556-1560 (Pubitemid 24106422)
    • (1994) Cancer Research , vol.54 , Issue.6 , pp. 1556-1560
    • Pellegata, N.S.1    Sessa, F.2    Renault, B.3    Bonato, M.4    Leone, B.E.5    Solcia, E.6    Ranzani, G.N.7
  • 31
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • DOI 10.1038/sj.cdd.4401183
    • Oren M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10(4):431-442 (Pubitemid 36626355)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.4 , pp. 431-442
    • Oren, M.1
  • 32
    • 84863244013 scopus 로고    scopus 로고
    • The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
    • press
    • Shen L et al (2012) The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy. Clinical Cancer Res (in press)
    • (2012) Clinical Cancer Res
    • Shen, L.1
  • 33
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • DOI 10.1158/0008-5472.CAN-03-0846
    • Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E (2004) The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 64(7):2627-2633 (Pubitemid 38523921)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 36
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • Hu Wet al (2010) Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA 107(16):7455-7460
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.16 , pp. 7455-7460
    • Wet Al., H.1
  • 38
    • 79954425673 scopus 로고    scopus 로고
    • Genome profiling of pancreatic adenocarcinoma
    • Birnbaum DJ et al (2011) Genome profiling of pancreatic adenocarcinoma. Genes Chromosomes Cancer 50(6):456-465
    • (2011) Genes Chromosomes Cancer , vol.50 , Issue.6 , pp. 456-465
    • Birnbaum, D.J.1
  • 41
    • 0023352241 scopus 로고
    • Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae
    • Sauer B (1987) Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae. Mol Cell Biol 7(6):2087-2096
    • (1987) Mol Cell Biol , vol.7 , Issue.6 , pp. 2087-2096
    • Sauer, B.1
  • 42
    • 0024041732 scopus 로고
    • Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
    • Sauer B, Henderson N (1988) Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85(14):5166-5170
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.14 , pp. 5166-5170
    • Sauer, B.1    Henderson, N.2
  • 43
    • 0026764280 scopus 로고
    • Tissue-and site-specific DNA recombination in transgenic mice
    • Orban PC, Chui D, Marth JD (1992) Tissue-and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89 (15):6861-6865
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.15 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 44
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • DOI 10.1038/371606a0
    • Jonsson J et al (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371(6498):606-609 (Pubitemid 24315741)
    • (1994) Nature , vol.371 , Issue.6498 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 47
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • DOI 10.1038/ng959
    • Kawaguchi Y et al (2002) The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32(1):128-134 (Pubitemid 34977207)
    • (2002) Nature Genetics , vol.32 , Issue.1 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.E.6
  • 50
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA et al (2012) Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 122:639-53
    • (2012) J Clin Invest , vol.122 , pp. 639-53
    • Collins, M.A.1
  • 51
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S et al (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321(5897): 1801-1806
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1
  • 52
    • 76249108357 scopus 로고    scopus 로고
    • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    • Morton JP et al (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci USA 107(1):246-251
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.1 , pp. 246-251
    • Morton, J.P.1
  • 53
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D, Saunders TL, Morrison SJ (2010) Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468(7324):653-658
    • (2010) Nature , vol.468 , Issue.7324 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 54
    • 78649851511 scopus 로고    scopus 로고
    • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
    • Gurumurthy S et al (2010) The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468(7324):659-663
    • (2010) Nature , vol.468 , Issue.7324 , pp. 659-663
    • Gurumurthy, S.1
  • 55
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan B et al (2010) Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-704
    • (2010) Nature , vol.468 , Issue.7324 , pp. 701-704
    • Gan, B.1
  • 58
    • 77955488036 scopus 로고    scopus 로고
    • LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    • 597 e1-6
    • Morton JP et al (2010) LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology 139(2):586-597, 597 e1-6
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 586-597
    • Morton, J.P.1
  • 59
    • 59849105832 scopus 로고    scopus 로고
    • Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice
    • e9
    • Bonal C et al (2009) Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology 136(1):309-319, e9
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 309-319
    • Bonal, C.1
  • 60
    • 58149402376 scopus 로고    scopus 로고
    • Conditional inactivation of Myc impairs development of the exocrine pancreas
    • Nakhai H et al (2008) Conditional inactivation of Myc impairs development of the exocrine pancreas. Development 135(19): 3191-3196
    • (2008) Development , vol.135 , Issue.19 , pp. 3191-3196
    • Nakhai, H.1
  • 62
    • 77955827414 scopus 로고    scopus 로고
    • Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    • Mazur PK et al (2010) Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci USA 107(30):13438-13443
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.30 , pp. 13438-13443
    • Mazur, P.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.