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Volumn 11, Issue 2, 2012, Pages 554-563

Proteomic analysis reveals warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells

Author keywords

glutamine; mass spectrometry; metabolism; pancreatic ductal adenocarcinoma; proteomics; Warburg effect

Indexed keywords

GLUTAMINE;

EID: 84856655854     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr2009274     Document Type: Article
Times cited : (65)

References (45)
  • 1
    • 0004155427 scopus 로고
    • W. H. Freeman and Company: NewYork
    • Stryer, L. Biochemistry; W. H. Freeman and Company: NewYork, 1995.
    • (1995) Biochemistry
    • Stryer, L.1
  • 2
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. On respiratory impairment in cancer cells Science 1956, 124 (3215) 269-270
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 3
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G.; Cantley, L. C.; Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 2009, 324 (5930) 1029-1033
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 4
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine, A. J.; Puzio-Kuter, A. M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes Science 2010, 330 (6009) 1340-1344
    • (2010) Science , vol.330 , Issue.6009 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 5
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol, W. H.; Bounds, P. L.; Dang, C. V. Otto Warburg's contributions to current concepts of cancer metabolism Nat. Rev. Cancer 2011, 11 (5) 325-337
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.5 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 6
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis, R. J.; Mancuso, A.; Daikhin, E.; Nissim, I.; Yudkoff, M.; Wehrli, S.; Thompson, C. B. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (49) 19345-19350
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.49 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 7
    • 79957991472 scopus 로고    scopus 로고
    • Glutaminase: A hot spot for regulation of cancer cell metabolism?
    • Erickson, J. W.; Cerione, R. A. Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget 2010, 1 (8) 734-740
    • (2010) Oncotarget , vol.1 , Issue.8 , pp. 734-740
    • Erickson, J.W.1    Cerione, R.A.2
  • 8
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis, R. J.; Cheng, T. Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer Oncogene 2010, 29 (3) 313-324
    • (2010) Oncogene , vol.29 , Issue.3 , pp. 313-324
    • Deberardinis, R.J.1    Cheng, T.2
  • 9
    • 34547160717 scopus 로고    scopus 로고
    • Biology and management of pancreatic cancer
    • Ghaneh, P.; Costello, E.; Neoptolemos, J. P. Biology and management of pancreatic cancer Gut 2007, 56 (8) 1134-1152
    • (2007) Gut , vol.56 , Issue.8 , pp. 1134-1152
    • Ghaneh, P.1    Costello, E.2    Neoptolemos, J.P.3
  • 10
    • 67149130222 scopus 로고    scopus 로고
    • Epigenetics and epigenetic alterations in pancreatic cancer
    • Omura, N.; Goggins, M. Epigenetics and epigenetic alterations in pancreatic cancer Int. J. Clin. Exp. Pathol. 2009, 2 (4) 310-326
    • (2009) Int. J. Clin. Exp. Pathol. , vol.2 , Issue.4 , pp. 310-326
    • Omura, N.1    Goggins, M.2
  • 11
    • 17844377326 scopus 로고    scopus 로고
    • Proteomic profiling of pancreatic cancer for biomarker discovery
    • Chen, R.; Pan, S.; Brentnall, T. A.; Aebersold, R. Proteomic profiling of pancreatic cancer for biomarker discovery Mol. Cell. Proteomics 2005, 4 (4) 523-533
    • (2005) Mol. Cell. Proteomics , vol.4 , Issue.4 , pp. 523-533
    • Chen, R.1    Pan, S.2    Brentnall, T.A.3    Aebersold, R.4
  • 12
    • 38349145372 scopus 로고    scopus 로고
    • The pancreatic cancer proteome - Recent advances and future promise
    • Aspinall-O'Dea, M.; Costello, E. The pancreatic cancer proteome - recent advances and future promise Proteomics Clin. Appl. 2007, 1 (9) 1066-1079
    • (2007) Proteomics Clin. Appl. , vol.1 , Issue.9 , pp. 1066-1079
    • Aspinall-O'Dea, M.1    Costello, E.2
  • 14
    • 68049111322 scopus 로고    scopus 로고
    • Pancreatic cancer: Proteomic approaches to a challenging disease
    • Tonack, S.; Aspinall-O'Dea, M.; Neoptolemos, J. P.; Costello, E. Pancreatic cancer: proteomic approaches to a challenging disease Pancreatology 2009, 9 (5) 567-576
    • (2009) Pancreatology , vol.9 , Issue.5 , pp. 567-576
    • Tonack, S.1    Aspinall-O'Dea, M.2    Neoptolemos, J.P.3    Costello, E.4
  • 16
  • 17
    • 0016793022 scopus 로고
    • Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas
    • Lieber, M.; Mazzetta, J.; Nelson-Rees, W.; Kaplan, M.; Todaro, G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas Int. J. Cancer 1975, 15 (5) 741-747
    • (1975) Int. J. Cancer , vol.15 , Issue.5 , pp. 741-747
    • Lieber, M.1    Mazzetta, J.2    Nelson-Rees, W.3    Kaplan, M.4    Todaro, G.5
  • 18
    • 59649095116 scopus 로고    scopus 로고
    • Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction
    • Klein, T.; Heremans, Y.; Heimberg, H.; Pipeleers, D.; Madsen, O. D.; Serup, P.; Heller, R. S. Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction Pancreas 2009, 38 (1) 36-48
    • (2009) Pancreas , vol.38 , Issue.1 , pp. 36-48
    • Klein, T.1    Heremans, Y.2    Heimberg, H.3    Pipeleers, D.4    Madsen, O.D.5    Serup, P.6    Heller, R.S.7
  • 19
    • 33847630405 scopus 로고    scopus 로고
    • Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
    • Elias, J. E.; Gygi, S. P. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry Nat. Methods 2007, 4 (3) 207-214
    • (2007) Nat. Methods , vol.4 , Issue.3 , pp. 207-214
    • Elias, J.E.1    Gygi, S.P.2
  • 21
    • 3242731195 scopus 로고    scopus 로고
    • A model for random sampling and estimation of relative protein abundance in shotgun proteomics
    • Liu, H.; Sadygov, R.; Yates, J. R., III A model for random sampling and estimation of relative protein abundance in shotgun proteomics Anal. Chem. 2004, 76 (14) 4193-4201
    • (2004) Anal. Chem. , vol.76 , Issue.14 , pp. 4193-4201
    • Liu, H.1    Sadygov, R.2    Yates Iii, J.R.3
  • 22
    • 26844559000 scopus 로고    scopus 로고
    • Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein
    • Ishihama, Y.; Oda, Y.; Tabata, T.; Sato, T.; Nagasu, T.; Rappsilber, J.; Mann, M. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein Mol. Cell. Proteomics 2005, 4 (9) 1265-1272
    • (2005) Mol. Cell. Proteomics , vol.4 , Issue.9 , pp. 1265-1272
    • Ishihama, Y.1    Oda, Y.2    Tabata, T.3    Sato, T.4    Nagasu, T.5    Rappsilber, J.6    Mann, M.7
  • 23
    • 0021955067 scopus 로고
    • Immunohistochemical localization of gamma-enolase in normal human tissues other than nervous and neuroendocrine tissues
    • Haimoto, H.; Takahashi, Y.; Koshikawa, T.; Nagura, H.; Kato, K. Immunohistochemical localization of gamma-enolase in normal human tissues other than nervous and neuroendocrine tissues Lab Invest. 1985, 52 (3) 257-263
    • (1985) Lab Invest. , vol.52 , Issue.3 , pp. 257-263
    • Haimoto, H.1    Takahashi, Y.2    Koshikawa, T.3    Nagura, H.4    Kato, K.5
  • 24
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • Wise, D. R.; Thompson, C. B. Glutamine addiction: a new therapeutic target in cancer Trends Biochem. Sci. 2010, 35 (8) 427-433
    • (2010) Trends Biochem. Sci. , vol.35 , Issue.8 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 25
    • 0018926713 scopus 로고
    • Increased cytidine 5′-triphosphate synthetase activity in rat and human tumors
    • Kizaki, H.; Williams, J. C.; Morris, H. P.; Weber, G. Increased cytidine 5′-triphosphate synthetase activity in rat and human tumors Cancer Res. 1980, 40 (11) 3921-3927
    • (1980) Cancer Res. , vol.40 , Issue.11 , pp. 3921-3927
    • Kizaki, H.1    Williams, J.C.2    Morris, H.P.3    Weber, G.4
  • 26
    • 0025232412 scopus 로고
    • Metabolism and action of amino acid analog anti-cancer agents
    • Ahluwalia, G. S.; Grem, J. L.; Hao, Z.; Cooney, D. A. Metabolism and action of amino acid analog anti-cancer agents Pharmacol. Ther. 1990, 46 (2) 243-271
    • (1990) Pharmacol. Ther. , vol.46 , Issue.2 , pp. 243-271
    • Ahluwalia, G.S.1    Grem, J.L.2    Hao, Z.3    Cooney, D.A.4
  • 27
    • 0025996404 scopus 로고
    • A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase
    • Cerini, C.; Kerjan, P.; Astier, M.; Gratecos, D.; Mirande, M.; Semeriva, M. A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase EMBO J. 1991, 10 (13) 4267-4277
    • (1991) EMBO J. , vol.10 , Issue.13 , pp. 4267-4277
    • Cerini, C.1    Kerjan, P.2    Astier, M.3    Gratecos, D.4    Mirande, M.5    Semeriva, M.6
  • 28
    • 33646895421 scopus 로고    scopus 로고
    • Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: Diagnostic and possible therapeutic implications
    • Orlandi, A.; Ferlosio, A.; Ciucci, A.; Francesconi, A.; Lifschitz-Mercer, B.; Gabbiani, G.; Spagnoli, L. G.; Czernobilsky, B. Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications Mod. Pathol. 2006, 19 (6) 797-803
    • (2006) Mod. Pathol. , vol.19 , Issue.6 , pp. 797-803
    • Orlandi, A.1    Ferlosio, A.2    Ciucci, A.3    Francesconi, A.4    Lifschitz-Mercer, B.5    Gabbiani, G.6    Spagnoli, L.G.7    Czernobilsky, B.8
  • 30
    • 79952488092 scopus 로고    scopus 로고
    • Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma
    • Raucci, R.; Colonna, G.; Guerriero, E.; Capone, F.; Accardo, M.; Castello, G.; Costantini, S. Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma Biochim. Biophys. Acta 2011, 1814 (4) 513-522
    • (2011) Biochim. Biophys. Acta , vol.1814 , Issue.4 , pp. 513-522
    • Raucci, R.1    Colonna, G.2    Guerriero, E.3    Capone, F.4    Accardo, M.5    Castello, G.6    Costantini, S.7
  • 32
    • 17144361820 scopus 로고    scopus 로고
    • Lysosomes as targets for cancer therapy
    • Fehrenbacher, N.; Jäättelä, M. Lysosomes as targets for cancer therapy Cancer Res. 2005, 65 (8) 2993-2995
    • (2005) Cancer Res. , vol.65 , Issue.8 , pp. 2993-2995
    • Fehrenbacher, N.1    Jäättelä, M.2
  • 33
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer, G.; Jäättelä, M. Lysosomes and autophagy in cell death control Nat. Rev. Cancer 2005, 5 (11) 886-897
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.11 , pp. 886-897
    • Kroemer, G.1    Jäättelä, M.2
  • 34
    • 0026779307 scopus 로고
    • Cathepsin D in breast cancer: A tissue marker associated with metastasis
    • Rochefort, H. Cathepsin D in breast cancer: a tissue marker associated with metastasis Eur. J. Cancer 1992, 28A, 1780-1783
    • (1992) Eur. J. Cancer , vol.28 , pp. 1780-1783
    • Rochefort, H.1
  • 35
    • 0027447152 scopus 로고
    • Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma
    • Motojima, K.; Urano, T.; Nagata, Y.; Shiku, H.; Tsurifune, T.; Kanematsu, T. Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma Ann. Surg. 1993, 217 (2) 138-143
    • (1993) Ann. Surg. , vol.217 , Issue.2 , pp. 138-143
    • Motojima, K.1    Urano, T.2    Nagata, Y.3    Shiku, H.4    Tsurifune, T.5    Kanematsu, T.6
  • 39
    • 79954524112 scopus 로고    scopus 로고
    • Mechanism of cell adaptation: When and how do cancer cells develop chemoresistance?
    • Fodale, V.; Pierobon, M.; Liotta, L.; Petricoin, E. Mechanism of cell adaptation: when and how do cancer cells develop chemoresistance? Cancer J. 2011, 17 (2) 89-95
    • (2011) Cancer J. , vol.17 , Issue.2 , pp. 89-95
    • Fodale, V.1    Pierobon, M.2    Liotta, L.3    Petricoin, E.4
  • 40
    • 0036918282 scopus 로고    scopus 로고
    • Impact of tumor hypoxia and anemia on radiation therapy outcomes
    • Harrison, L. B.; Chadha, M.; Hill, R. J.; Hu, K.; Shasha, D. Impact of tumor hypoxia and anemia on radiation therapy outcomes Oncologist 2002, 7 (6) 492-508
    • (2002) Oncologist , vol.7 , Issue.6 , pp. 492-508
    • Harrison, L.B.1    Chadha, M.2    Hill, R.J.3    Hu, K.4    Shasha, D.5
  • 41
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano, H.; Martin, D. S.; Xu, R. H.; Huang, P. Glycolysis inhibition for anticancer treatment Oncogene 2006, 25 (34) 4633-4646
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 42
    • 77956249320 scopus 로고    scopus 로고
    • Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse
    • Shelton, L. M.; Huysentruyt, L. C.; Mukherjee, P.; Seyfried, T. N. Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse ASN Neuro. 2010, 2 (3) e00038
    • (2010) ASN Neuro. , vol.2 , Issue.3 , pp. 00038
    • Shelton, L.M.1    Huysentruyt, L.C.2    Mukherjee, P.3    Seyfried, T.N.4
  • 43
    • 33645813378 scopus 로고    scopus 로고
    • Mass spectrometry and protein analysis
    • Domon, B.; Aebersold, R. Mass spectrometry and protein analysis Science 2006, 312 (5771) 212-217
    • (2006) Science , vol.312 , Issue.5771 , pp. 212-217
    • Domon, B.1    Aebersold, R.2
  • 44
    • 37249014081 scopus 로고    scopus 로고
    • The biological impact of mass-spectrometry-based proteomics
    • Cravatt, B. F.; Simon, G. M.; Yates, J. R., III The biological impact of mass-spectrometry-based proteomics Nature 2007, 450 (7172) 991-1000
    • (2007) Nature , vol.450 , Issue.7172 , pp. 991-1000
    • Cravatt, B.F.1    Simon, G.M.2    Yates Iii, J.R.3


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