Health benefits of almonds beyond cholesterol reduction

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 27, 2012, Pages 6694-6702

  Kamil, Alison ^a   Chen, C Y Oliver ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

almonds; anti inflammation; antioxidation; body weight; cholesterol; glucoregulation

Indexed keywords

ALMONDS; ANTI-INFLAMMATION; ANTI-OXIDATION; BODY WEIGHT; GLUCOREGULATION;

ANTHROPOMETRY; GLUCOSE; MAGNESIUM; NUTRIENTS; PATHOLOGY;

CHOLESTEROL;

CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT;

CHEMISTRY; DIET THERAPY; HEALTH FOOD; HUMAN; METABOLISM; NUT; PRUNUS; REVIEW;

ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; DIET THERAPY; HEALTH FOOD; HUMANS; NUTS; PRUNUS;

PRUNUS DULCIS;

EID: 84863958659     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf2044795     Document Type: Review

References (59)

1. Rieger, M. Introduction to Fruit Crops; CRC: Boca Raton, FL, 2006.
2. Salas-Salvadó, J.; Casas-Agustench, P.; Salas-Huetos, A. Cultural and historical aspects of Mediterranean nuts with emphasis on their attributed healthy and nutritional properties Nutr. Metab. Cardiovasc. 2010, 21 (Suppl. 1) S1-S6
3. Almond almanac 2011; http://www.almondboard.com/AboutTheAlmondBoard/ Pages/ResearchStats.aspx (accessed Feb 201, 2).
4. Lloyd, J. U. Origin and History of All the Pharmacopeial Vegetable Drugs, Chemicals and Preparations with Bibliography; Caxton Press: Caldwell, ID, 1921; Vol. 1.
5. Dicenta, F.; Martínez-Gómez, P.; Grané, N.; Martín, M. L.; León, A.; Cánovas, J. A.; Berenguer, V. A relationship between cyanogenic compounds in kernels, leaves, and roots of sweet and bitter kerneled almonds J. Agric. Food Chem. 2002, 50 (7) 2149-2152
6. Chen, C. Y.; Lapsley, K.; Blumberg, J. A nutrition and health perspective on almonds J. Sci. Food Agric. 2006, 86 (14) 2245-2250
7. Ahrens, S.; Venkatachalam, M.; Mistry, A. M.; Lapsley, K.; Sathe, S. K. Almond (Prunus dulcis L.) protein quality Plant Foods Hum. Nutr. 2005, 60 (3) 123-128
8. Bolling, B. W.; McKay, D. L.; Blumberg, J. B. The phytochemical composition and antioxidant actions of tree nuts Asia Pac. J. Clin. Nutr. 2010, 19 (1) 117-123
9. Bolling, B. W.; Dolnikowski, G.; Blumberg, J. B.; Chen, C. Y. Polyphenol content and antioxidant activity of California almonds depend on cultivar and harvest year J. Food Chem. 2010, 122, 819-825
10. Urpi-Sarda, M; Garrido, I; Monagas, M.; Gómez-Cordovés, C.; Medina-Remón, A.; Andres-Lacueva, C.; Bartolomé, B. Profile of plasma and urine metabolites after the intake of almond [ Prunus dulcis (Mill.)] polyphenols in humans J. Agric. Food Chem. 2009, 57, 10134-10142
11. Berryman, C. E.; Preston, A. G.; Karmally, W.; Deckelbaum, R. J.; Kris-Etherton, P. M. Effects of almond consumption on the reduction of LDL-cholesterol: a discussion of potential mechanisms and future research directions Nutr. Rev. 2011, 69 (4) 171-185
12. Sabaté, J.; Haddad, E.; Tanzman, J. S.; Jambazian, P.; Rajaram, S. Serum lipid response to the graduated enrichment of a Step I diet with almonds: a randomized feeding trial Am. J. Clin. Nutr. 2003, 77 (6) 1379-1384
13. Jenkins, D. J. A.; Kendall, C. W. C.; Marchie, A. The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia* 1 Metabolsim 2003, 52 (11) 1478-1483
14. Spiller, G. A.; Jenkins, D. A. J.; Bosello, O.; Gates, J. E.; Cragen, L. N.; Bruce, B. Nuts and plasma lipids: an almond-based diet lowers LDL-C while preserving HDL-C J. Am. Coll. Nutr. 1998, 17 (3) 285-290
15. Hyson, D. A.; Schneeman, B. O.; Davis, P. A. Almonds and almond oil have similar effects on plasma lipids and LDL oxidation in healthy men and women J. Nutr. 2002, 132 (4) 703-707
16. Jenkins, D. J. A.; Kendall, C. W. C.; Marchie, A. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein (a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial Circulation 2002, 106 (11) 1327-1332
17. Wolfe, B. M.; Giovannetti, P. M. Short-term effects of substituting protein for carbohydrate in the diets of moderately hypercholesterolemic human subjects Metabolism 1991, 40 (4) 338-343
18. Appel, L. J.; Sacks, F. M.; Carey, V. J. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids JAMA, J. Am. Med. Assoc. 2005, 294 (19) 2455-2464
19. Kohls, K.; Kies, C.; Fox, H. Blood serum lipid levels of humans given arginine, lysine and tryptophan supplements without food Nutr. Rep. Int. 1987, 35 (1) 5-13
20. Salas-Salvadó, J.; Bulló, M.; Pérez-Heras, A.; Ros, E. Dietary fibre, nuts and cardiovascular diseases Br. J. Nutr. 2006, 96 (1) 45-51
21. Van Bennekum, A. M.; Nguyen, D. V.; Schulthess, G.; Hauser, H.; Phillips, M. C. Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters Br. J. Nutr. 2005, 94 (03) 331-337
22. Hollis, J.; Mattes, R. Effect of chronic consumption of almonds on body weight in healthy humans Br. J. Nutr. 2007, 98 (03) 651-656
23. Expert Panel on Detection Evaluation. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA., J. Am. Med. Assoc. 2001, 285 (19), 2486-2497.
24. Segura, R.; Javierre, C.; Lizarraga, M. A.; Ros, E. Other relevant components of nuts: phytosterols, folate and minerals Br. J. Nutr. 2006, 96 (S2) S36-S44
25. Sabaté, J. Nut consumption and body weight Am. J. Clin. Nutr. 2003, 78 (3) 647S-650S
26. Fraser, G. E.; Bennett, H. W.; Jaceldo, K. B.; Sabate, J. Effect on body weight of a free 76 kilojoule (320 calorie) daily supplement of almonds for six months J. Am. Coll. Nutr. 2002, 21 (3) 275-283
27. Ellis, P. R.; Kendall, C. W. C.; Ren, Y. Role of cell walls in the bioaccessibility of lipids in almond seeds Am. J. Clin. Nutr. 2004, 80 (3) 604-613
28. Zemaitis, J.; Sabaté, J. Effect of almond consumption on stool weight and stool fat FASEB J. 2001, 15 (4) A602
29. Cassady, B. A.; Hollis, J. H.; Fulford, A. D.; Considine, R. V.; Mattes, R. D. Mastication of almonds: effects of lipid bioaccessibility, appetite, and hormone response Am. J. Clin. Nutr. 2009, 89 (3) 794-800
30. Howard, B. V.; Van Horn, L.; Hsia, J. Low-fat dietary pattern and risk of cardiovascular disease JAMA, J. Am. Med. Assoc. 2006, 295 (6) 655-666
31. Wien, M.; Sabate, J.; Ikle, D.; Cole, S.; Kandeel, F. Almonds vs complex carbohydrates in a weight reduction program Int. J. Obes. 2003, 27 (11) 1365-1372
32. Scott, L. W.; Balasubramanyam, A.; Kimball, K. T.; Aherns, A. K.; Fordis, C. M.; Ballantyne, C. M. Long-term, randomized clinical trial of two diets in the metabolic syndrome and type 2 diabetes Diabetes Care 2003, 26 (8) 2481-2482
33. Jenkins, D. J. A.; Hu, F. B.; Tapsell, L. C.; Josse, A. R.; Kendall, C. W. C. Possible benefit of nuts in type 2 diabetes J. Nutr. 2008, 138 (9) 1752S-1756S
34. Josse, A. R.; Kendall, C. W. C.; Augustin, L. S. A.; Ellis, P. R.; Jenkins, D. J. A. Almonds and postprandial glycemia - a dose-response study Metabolism 2007, 56 (3) 400-404
35. Jenkins, D. J. A.; Kendall, C. W. C.; Josse, A. R. Almonds decrease postprandial glycemia, insulinemia, and oxidative damage in healthy individuals J. Nutr. 2006, 136 (12) 2987-2992
36. Mori, A. M.; Considine, R. V.; Mattes, R. D. Acute and second-meal effects of almond form in impaired glucose tolerant adults: a randomized crossover trial Nutr. Metab. 2011, 8 (1) 6
37. Cohen, A. E.; Johnston, C. S. Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A1c in individuals with well-controlled type 2 diabetes mellitus Metabolsim 2011, 1312-1317
38. Bantle, J. P.; Wylie-Rosett, J.; Albright, A. L. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association Diabetes Care 2008, 31, S61-S78
39. Lovejoy, J. C.; Most, M. M.; Lefevre, M.; Greenway, F. L.; Rood, J. C. Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes Am. J. Clin. Nutr. 2002, 76 (5) 1000-1006
40. Li, S. C.; Liu, Y. H.; Liu, J. F.; Chang, W. H.; Chen, C. M.; Chen, C. Y. O. Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus. Metabolism 2010, not supplied.
41. Coutinho, M.; Gerstein, H. C.; Wang, Y.; Yusuf, S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years Diabetes Car. 1999, 22 (2) 233-240
42. Yoon, J. H.; Thompson, L. U.; Jenkins, D. The effect of phytic acid on in vitro rate of starch digestibility and blood glucose response Am. J. Clin. Nutr. 1983, 38 (6) 835-842
43. Lo, P. E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C. Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase J. Med. Chem. 2008, 51 (12) 3555-3561
44. Chen, C. Y.; Milbury, P. E.; Lapsley, K.; Blumberg, J. B. Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation J. Nutr. 2005, 135 (6) 1366-1373
45. Chen, C. Y. O.; Blumberg, J. B. In vitro activity of almond skin polyphenols for scavenging free radicals and inducing quinone reductase J. Agric. Food Chem. 2008, 56 (12) 4427-4434
46. Jambazian, P. R.; Haddad, E.; Rajaram, S.; Tanzman, J.; Sabaté, J. Almonds in the diet simultaneously improve plasma α-tocopherol concentrations and reduce plasma lipids J. Am. Diet. Assoc. 2005, 105 (3) 449-454
47. Jenkins, D. J. A.; Kendall, C. W. C.; Marchie, A. Almonds reduce biomarkers of lipid peroxidation in older hyperlipidemic subjects J. Nutr. 2008, 138 (5) 908-913
48. Jalali-Khanabadi, B. A.; Mozaffari-Khosravi, H.; Parsaeyan, N. Effects of almond dietary supplementation on coronary heart disease lipid risk factors and serum lipid oxidation parameters in men with mild hyperlipidemia J. Altern. Complement. Med. 2010, 16 (12) 1279-1283
49. Chen, C. Y. O.; Liu, J. F.; Liu, Y. H.; Chang, W. H.; Chen, C. M. Almonds decreased inflammation and oxidative stress in patients with type 2 diabetes mellitus. FASEB J. 2011, 25 (107.5).
50. Li, N. Almond consumption reduces oxidative DNA damage and lipid peroxidation in male smokers J. Nutr. 2007, 137, 2717-2722
51. Pradhan, A.; Ridker, P. Do atherosclerosis and type 2 diabetes share a common inflammatory basis? Eur. Heart J. 2002, 23 (11) 831-834
52. Luc, G.; Bard, J. M.; Juhan-Vague, I. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study Arterioscler., Thromb., Vasc. Biol. 2003, 23 (7) 1255-1261
53. Pradhan, A. D.; Manson, J. A. E.; Rifai, N.; Buring, J. E.; Ridker, P. M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus JAMA, J. Am. Med. Assoc. 2001, 286 (3) 327-334
54. Jiang, R.; Jacobs, D. R.; Mayer-Davis, E. Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis Am. J. Epidemiol. 2006, 163 (3) 222-231
55. Rajaram, S.; Connell, K. M.; Sabaté, J. Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study Br. J. Nutr. 2010, 103 (06) 907-912
56. Jenkins, D.; Kendall, C.; Marchie, A. Direct comparison of dietary portfolio vs statin on C-reactive protein Eur. J. Clin Nutr. 2005, 59 (7) 851-860
57. Estruch, R.; Martínez-González, M. A.; Corella, D. Effects of a Mediterranean-style diet on cardiovascular risk factors Ann. Intern. Med. 2006, 145 (1-11) 1
58. Salas-Salvadó, J.; Garcia-Arellano, A.; Estruch, R. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease Eur. J. Clin. Nutr. 2007, 62 (5) 651-659
59. Mena, M. P.; Sacanella, E.; Vazquez-Agell, M. Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet Am. J. Clin. Nutr. 2009, 89 (1) 248-256