Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: Relationships with intestinal and hepatic cholesterol parameters

British Journal of Nutrition

Volumn 94, Issue 3, 2005, Pages 331-337

  van Bennekum, Ariëtte M ^a   Nguyen, David V ^a   Schulthess, Georg ^b   Hauser, Helmut ^c   Phillips, Michael C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Bile acid; Cholesterol lowering; Dietary fibres; Intestinal cholesterol absorption

Indexed keywords

BILE ACID; CELLULOSE; CHITOSAN; COLESTYRAMINE; STEROL;

ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; BILE ACID METABOLISM; BILIARY EXCRETION; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY FIBER; FECES ANALYSIS; FEMALE; FOOD ANALYSIS; FOOD COMPOSITION; FOOD INTAKE; HYPOCHOLESTEROLEMIA; INTESTINE ABSORPTION; LIPID DIET; MOUSE; NONHUMAN; SATIETY;

ANIMALS; BILE ACIDS AND SALTS; CELLULOSE; CHITOSAN; CHOLESTEROL; CHOLESTYRAMINE; DIETARY FATS; DIETARY FIBER; FECES; FEMALE; HOMEOSTASIS; INTESTINAL ABSORPTION; LIVER; MICE; MICE, INBRED C57BL; SATIATION;

EID: 26044452076     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN20051498     Document Type: Article

References (39)

1. Ausar SF, Morcillo M, Leon AE, et al. (2003) Improvement of HDL- and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan. J Med Food 6, 397-399.
2. Bartlett GR (1959) Phosphorus assay in column chromatography. J Biol Chem 234, 466-468.
3. Bokura H & Kobayashi S (2003) Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 57, 721-725.
4. Brown WV (1990) Clinical trials including an update on the Helsinki Heart study. Am J Cardiol 66, 11A-15A.
5. Burton-Freeman B (2000) Dietary fiber and energy regulation. J Nutr 130, 272S-275S.
6. Carter CP, Howles PN & Hui DY (1997) Genetic variation in cholesterol absorption efficiency among inbred strains of mice. J Nutr 127, 1344-1348.
7. Casdorph HR (1967) Treatment of hypercholesterolemia with cholestyramine, a bile acid sequestering resin. Vasc Dis 4, 305-308.
8. Castelli WP (1984) Epidemiology of coronary heart disease: The Framingham study. Am J Med 76, 4-12.
9. Chen WJL & Anderson JW (1979) Effects of plant fiber in decreasing plasma total cholesterol and increasing high-density lipoprotein cholesterol. Proc Soc Exp Biol Med 162, 310-313.
10. Cohen DE (1999) Hepatocellular transport and secretion of biliary lipids. Curr Opin Lipidol 10, 295-302.
11. Farkas J, Angel A & Avigan MI (1973) Studies on the compartmentation of lipid in adipose cells. II. Cholesterol accumulation and distribution in adipose tissue components. J Lipid Res 14, 344-356.
12. Fernandez ML (2001) Soluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk. Curr Opin Lipidol 12, 35-40.
13. Furda I (1983) Aminopolysaccharides - their potential as dietary fiber. In Unconventional Sources of Dietary Fiber, pp. 105-122 [I Furda, editor]. ACS Symposium Series no. 214. Washington DC, USA: American Chemical Society.
14. Furda I (1990) Interaction of dietary fiber with lipids - mechanistic theories and their limitations. Adv Exp Med Biol 270, 67-82.
15. Gallaher CM, Munion J, Hesslink RJ, Wise J & Gallaher DD (2000) Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats. J Nutr 130, 2753-2759.
16. Grundy SM (1983) Absorption and metabolism of dietary cholesterol. Annu Rev Nutr 3, 71-96.
17. Grundy SM, Ahrens EH & Salen G (1968) Dietary β-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies. J Lipid Res 9, 374-387.
18. Gylling H, Vanhanen H & Miettinen TA (1989) Effects of acipimox and cholestyramine on serum lipoproteins, non-cholesterol sterols and cholesterol absorption and elimination. Eur J Clin Pharmacol 37, 111-115.
19. Han LK, Kimura Y & Okuda H (1999) Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int J Obesity 23, 174-179.
20. Homan R & Krause BR (1997) Established and emerging strategies for inhibition of cholesterol absorption. Curr Pharm Design 3, 29-44.
21. Ishikawa TT, MacGee J, Morrison JA & Glueck CJ (1974) Quantitative analysis of cholesterol in 5 to 20 μl of plasma. J Lipid Res 15, 286-291.
22. Jennings CD, Boleyn K, Bridges SR, Wood PJ & Anderson JW (1988) A comparison of the lipid-lowering and intestinal morphological effects of cholestyramine, chitosan, and oat gum in rats. Proc Soc Exp Biol Med 189, 13-20.
23. Kesaniemi YA & Miettinen TA (1987) Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population. Eur J Clin Invest 17, 391-395.
24. Lee JK, Kim SU & Kim JH (1999) Modification of chitosan to improve its hypocholesterolemic capacity. Biosci Biotechnol Biochem 63, 833-839.
25. Maezaki Y, Tsuji K, Nakagawa Y, Kawai Y, Akimoto M, Tsugita T, Takekawa W, Terada A, Hara H & Mitsuoka T (1993) Hypocholesterolemic effect of chitosan in adult males. Biosci Biotech Biochem 57, 1439-1444.
26. Mhurchu CN, Poppitt SD, McGill AT, Leahy FE, Bennett DA, Lin R, Ormod D, Ward L, Strik C & Rodgers A (2004) The effect of the dietary supplement, chitosan, on body weight; a randomized controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord 28, 1149-1156.
27. Pittler MH, Abbot NC, Harkness EF & Ernst E (1999) Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr 53, 379-381.
28. Schiller LR, Bilhartz LE, Santa Ana CA & Fordtran JS (1990) Comparison of endogenous and radiolabeled bile acid excretion in patients with idiopathic chronic diarrhea. Gastroenterology 98, 1036-1043.
29. Sehayek E, Nath C, Heinemann T, McGee M, Seidman CE, Samuel P & Breslow JL (1998) U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans. J Lipid Res 39, 2415-2422.
30. Shurpalekar KS, Doraiswamy TR, Sundaravalli OE & Narayana Rao M (1971) Effect of inclusion of cellulose in an 'atherogenic' diet on the blood lipids of children. Nature 232, 554-555.
31. Stanley MM, Paul D, Gacke D & Murphy J (1973) Effects of cholestyramine, metamucil, and cellulose on fecal bile salt excretion in man. Gastroenterology 65, 889-894.
32. Story JA, Furumoto EJ & Buhman KK (1997) Dietary fiber and bile acid metabolism-an update. Adv Exp Med Biol 427, 259-266.
33. Trautwein EA, Jürgensen U & Erbersdobler HF (1997) Cholesterol-lowering and gallstone-preventing action of chitosans with different degrees of deacetylation in hamsters fed cholesterol-rich diets. Nutr Res 17, 1053-1065.
34. Turley SD, Daggy BP & Dietschy JM (1994) Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver. Gastroenterology 107, 444-452.
35. Turley SD, Daggy BP & Dietschy JM (1996) Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia. J Cardiovasc Pharmacol 27, 71-79.
36. Turley SD & Dietschy JM (1978) Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res 19, 924-928.
37. Vahouny GV, Roy T, Gallo LL, Story JA, Kritchevsky D & Cassidy M (1980a) Dietary fibers III. Effects of chronic intake on cholesterol absorption and metabolism in the rat. Am J Clin Nutr 33, 2182-2191.
38. Vahouny GV, Tombes R, Cassidy MM, Kritchevsky D & Gallo LL (1980b) Dietary fibers: V. Binding of bile salts, phospholipids and cholesterol from mixed micelles by bile acid sequestrants and dietary fibers. Lipids 15, 1012-1018.
39. Ylitalo R, Lehtinen S, Wuolijoki E, Ylitalo P & Lehtimaki T (2002) Cholesterol-lowering properties and safety of chitosan. Arzneimittelforschung 52, 1-7.