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Volumn 16, Issue 8, 2012, Pages 747-759

MicroRNAs as therapeutic targets and their potential applications in cancer therapy

Author keywords

Cancer; MicroRNA; Oncogene; Oncomir; Therapeutic target; Tumor suppressor gene

Indexed keywords

ANTAGOMIR; CPG OLIGODEOXYNUCLEOTIDE; DICER; DICER 1 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HERMES ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA; MICRORNA 100; MICRORNA 10B; MICRORNA 145; MICRORNA 21; MICRORNA 210; MICRORNA 211; MICRORNA 223; MICRORNA 9; PROTEIN KINASE B; SMAD3 PROTEIN; SMAD7 PROTEIN; SMALL UNTRANSLATED RNA; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRASTUZUMAB; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNTRANSLATED RNA;

EID: 84863906869     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2012.696102     Document Type: Review
Times cited : (63)

References (79)
  • 1
    • 77956746299 scopus 로고    scopus 로고
    • Conquering cancer through discovery research
    • Cho WC. Conquering cancer through discovery research. IUBMB Life 2010;62:655-9
    • (2010) IUBMB Life , vol.62 , pp. 655-659
    • Cho, W.C.1
  • 2
    • 82755189644 scopus 로고    scopus 로고
    • Calin GA. microRNA history: Discovery, recent applications, and next frontiers
    • Almeida MI, Reis RM, Calin GA. microRNA history: Discovery, recent applications, and next frontiers. Mutat Res 2011;717:1-8
    • (2011) Mutat. Res. , vol.717 , pp. 1-8
    • Almeida, M.I.1    Reis, R.M.2
  • 3
    • 77954386364 scopus 로고    scopus 로고
    • Cho WC. microRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy
    • Cho WC. microRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy. Int J Biochem Cell Biol 2010;42:1273-81
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1273-1281
  • 4
    • 77949261485 scopus 로고    scopus 로고
    • Micrornas in cancer - From research to therapy
    • Cho WC. microRNAs in cancer - from research to therapy. Biochim Biophys Acta 2010;1805:209-17
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 209-217
    • Cho, W.C.1
  • 7
    • 79957773360 scopus 로고    scopus 로고
    • Small molecules with big effects: The role of the microRNAome in cancer and carcinogenesis
    • Koturbash I, Zemp FJ, Pogribny I, et al. Small molecules with big effects: The role of the microRNAome in cancer and carcinogenesis. Mutat Res 2011;722:94-105
    • (2011) Mutat. Res. , vol.722 , pp. 94-105
    • Koturbash, I.1    Zemp, F.J.2    Pogribny, I.3
  • 9
    • 79955543736 scopus 로고    scopus 로고
    • The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis
    • Babashah S, Soleimani M. The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis. Eur J Cancer 2011;47:1127-37
    • (2011) Eur. J. Cancer , vol.47 , pp. 1127-1137
    • Babashah, S.1    Soleimani, M.2
  • 10
    • 84870823182 scopus 로고    scopus 로고
    • Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo
    • publish 6 Feb 2012 doi:10.1038/onc.2012.15
    • Leucci E, Zriwil A, Gregersen LH, et al. Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo. Oncogene 2012;publish 6 Feb 2012; doi:10.1038/onc.2012.15
    • (2012) Oncogene
    • Leucci, E.1    Zriwil, A.2    Gregersen, L.H.3
  • 11
    • 84855349331 scopus 로고    scopus 로고
    • Mir-100 regulates cell differentiation and survival by targeting RBSP3 a phosphatase-like tumor suppressor in acute myeloid leukemia
    • Zheng YS, Zhang H, Zhang XJ, et al. miR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene 2012;31:80-92
    • (2012) Oncogene , Issue.31 , pp. 80-92
    • Zheng, Y.S.1    Zhang, H.2    Zhang, X.J.3
  • 12
    • 84866422595 scopus 로고    scopus 로고
    • Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155
    • publish online 16 Jan 2012 doi:10.1038/onc.2011.579
    • Lee DW, Futami M, Carroll M, et al. Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. Oncogene 2012;publish online 16 Jan 2012; doi:10.1038/onc.2011.579
    • (2012) Oncogene
    • Lee, D.W.1    Futami, M.2    Carroll, M.3
  • 13
    • 84855303345 scopus 로고    scopus 로고
    • Microrna-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5
    • Cai C, Ashktorab H, Pang X, et al. microRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS ONE 2012;7:e29750
    • (2012) Plos One , Issue.7
    • Cai, C.1    Ashktorab, H.2    Pang, X.3
  • 14
    • 78650858038 scopus 로고    scopus 로고
    • MiR-301a as an NF-kappaB activator in pancreatic cancer cells
    • Lu Z, Li Y, Takwi A, et al. miR-301a as an NF-kappaB activator in pancreatic cancer cells. EMBO J 2011;30:57-67.
    • (2011) Embo J. , vol.30 , pp. 57-67
    • Lu, Z.1    Li, Y.2    Takwi, A.3
  • 15
    • 79953225838 scopus 로고    scopus 로고
    • Microrna-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro
    • Jin Z, Selaru FM, Cheng Y, et al. microRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene 2011;30:1577-85
    • (2011) Oncogene , vol.30 , pp. 1577-1585
    • Jin, Z.1    Selaru, F.M.2    Cheng, Y.3
  • 16
    • 79960670757 scopus 로고    scopus 로고
    • Mirna-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3
    • Li X, Zhang Y, Zhang H, et al. miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3.Mol Cancer Res 2011;9:824-33
    • (2011) Mol. Cancer Res. , vol.9 , pp. 824-833
    • Li, X.1    Zhang, Y.2    Zhang, H.3
  • 17
    • 84861348585 scopus 로고    scopus 로고
    • Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/ FOXP1 signalling
    • Yang MH, Lin BR, Chang CH, et al. Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/ FOXP1 signalling. Oncogene 2012;31:2401-11.
    • (2012) Oncogene , Issue.31 , pp. 2401-2411
    • Yang, M.H.1    Lin, B.R.2    Chang, C.H.3
  • 18
    • 84867401829 scopus 로고    scopus 로고
    • Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer
    • publish online 23 Jan 2012 doi:10.1038/onc.2011.624
    • Jalava SE, Urbanucci A, Latonen L, et al. Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Oncogene 2012;publish online 23 Jan 2012; doi:10.1038/onc.2011.624
    • (2012) Oncogene
    • Jalava, S.E.1    Urbanucci, A.2    Latonen, L.3
  • 19
    • 84857355139 scopus 로고    scopus 로고
    • Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
    • Kim K, Chadalapaka G, Lee SO, et al. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene 2012;31:1034-44
    • (2012) Oncogene , Issue.31 , pp. 1034-1044
    • Kim, K.1    Chadalapaka, G.2    Lee, S.O.3
  • 20
    • 84856369168 scopus 로고    scopus 로고
    • Mir-99a and miR-99b modulate TGF-beta induced epithelial to mesenchymal plasticity in normal murine mammary gland cells
    • Turcatel G, Rubin N, El-Hashash A, et al. miR-99a and miR-99b modulate TGF-beta induced epithelial to mesenchymal plasticity in normal murine mammary gland cells. PLoS One 2012;7:e31032
    • (2012) Plos One , Issue.7
    • Turcatel, G.1    Rubin, N.2    El-Hashash, A.3
  • 21
    • 84871246002 scopus 로고    scopus 로고
    • The miR-106b-25 cluster targets Smad7activates TGF-beta signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
    • publish online 30 Jan 2012 doi:10.1038/onc.2012.11
    • Smith AL, Iwanaga R, Drasin DJ, et al. The miR-106b-25 cluster targets Smad7,activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 2012;publish online 30 Jan 2012; doi:10.1038/onc.2012.11
    • (2012) Oncogene
    • Smith, A.L.1    Iwanaga, R.2    Drasin, D.J.3
  • 22
    • 79953043006 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
    • Wang Y, Yu Y, Tsuyada A, et al. Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene 2011;30:1470-80
    • (2011) Oncogene , vol.30 , pp. 1470-1480
    • Wang, Y.1    Yu, Y.2    Tsuyada, A.3
  • 23
    • 83555171758 scopus 로고    scopus 로고
    • Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth
    • Yan LX, Wu QN, Zhang Y, et al. Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res 2011;13:R2
    • (2011) Breast Cancer Res. , vol.13
    • Yan, L.X.1    Wu, Q.N.2    Zhang, Y.3
  • 24
    • 79951516643 scopus 로고    scopus 로고
    • Microrna-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sezary syndrome
    • van Der Fits L, van Kester MS, Qin Y, et al. microRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sezary syndrome. J Invest Dermatol 2011;131:762-8
    • (2011) J. Invest. Dermatol. , vol.131 , pp. 762-768
    • Van Der Fits, L.1    Van Kester, M.S.2    Qin, Y.3
  • 25
    • 79957611696 scopus 로고    scopus 로고
    • Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas
    • Kwak HJ, Kim YJ, Chun KR, et al. Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Oncogene 2011;30:2433-42
    • (2011) Oncogene , vol.30 , pp. 2433-2442
    • Kwak, H.J.1    Kim, Y.J.2    Chun, K.R.3
  • 26
    • 79956085051 scopus 로고    scopus 로고
    • Human glioma growth is controlled by microRNA-10b
    • Gabriely G, Yi M, Narayan RS, et al. Human glioma growth is controlled by microRNA-10b. Cancer Res 2011;71:3563-72
    • (2011) Cancer Res. , vol.71 , pp. 3563-3572
    • Gabriely, G.1    Yi, M.2    Narayan, R.S.3
  • 27
    • 79958753869 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA-10b and targeting of oncogenic mapre1 in gastric cancer
    • Kim K, Lee HC, Park JL, et al. Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer. Epigenetics 2011;6:740-51
    • (2011) Epigenetics , vol.6 , pp. 740-751
    • Kim, K.1    Lee, H.C.2    Park, J.L.3
  • 28
    • 79955513982 scopus 로고    scopus 로고
    • Microrna-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab
    • Nishida N, Mimori K, Fabbri M, et al. microRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res 2011;17:2725-33
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2725-2733
    • Nishida, N.1    Mimori, K.2    Fabbri, M.3
  • 29
    • 84867742955 scopus 로고    scopus 로고
    • Microrna-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers
    • publish online 9 Dec 2011 doi:10.1038/onc.2011.581
    • Zheng B, Liang L, Huang S, et al. microRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene 2012;publish online 9 Dec 2011; doi:10.1038/onc.2011.581
    • (2012) Oncogene
    • Zheng, B.1    Liang, L.2    Huang, S.3
  • 30
    • 84861567957 scopus 로고    scopus 로고
    • Mir-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma
    • Fang YX, Xue JL, ShenQ, et al. miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. Hepatology 2012;55:1852-62
    • (2012) Hepatology , vol.55 , pp. 1852-1862
    • Fang, Y.X.1    Xue, J.L.2    Shen, Q.3
  • 31
    • 80655149145 scopus 로고    scopus 로고
    • Kim IA. microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling
    • Lee KM, Choi EJ, Kim IA. microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Radiother Oncol 2011;101:171-6
    • (2011) Radiother. Oncol. , vol.101 , pp. 171-176
    • Lee, K.M.1    Choi, E.J.2
  • 32
    • 79551527320 scopus 로고    scopus 로고
    • MiRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways
    • Saydam O, Senol O, Wurdinger T, et al. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res 2011;71:852-61
    • (2011) Cancer Res. , vol.71 , pp. 852-861
    • Saydam, O.1    Senol, O.2    Wurdinger, T.3
  • 33
    • 85011937497 scopus 로고    scopus 로고
    • Mir-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1
    • Cho WC, Chow AS, Au JS. miR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA Biol 2011;8:125-31
    • (2011) RNA Biol. , vol.8 , pp. 125-131
    • Cho, W.C.1    Chow, A.S.2    Au, J.S.3
  • 34
    • 84871958603 scopus 로고    scopus 로고
    • Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop
    • publish online 13 Feb 2012 doi:10.1038/onc.2012.28
    • Zhang J, Sun Q, Zhang Z, et al. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene 2012;publish online 13 Feb 2012; doi:10.1038/onc.2012.28
    • (2012) Oncogene
    • Zhang, J.1    Sun, Q.2    Zhang, Z.3
  • 35
    • 79953029421 scopus 로고    scopus 로고
    • MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2
    • Zhang JG, Guo JF, Liu DL, et al. microRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2. J Thorac Oncol 2011;6:671-8
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 671-678
    • Zhang, J.G.1    Guo, J.F.2    Liu, D.L.3
  • 36
    • 80055080741 scopus 로고    scopus 로고
    • Microrna-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells
    • Feng S, Cong S, Zhang X, et al. microRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res 2011;39:6669-78
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6669-6678
    • Feng, S.1    Cong, S.2    Zhang, X.3
  • 37
    • 79960434259 scopus 로고    scopus 로고
    • Microrna-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma
    • Paik JH, Jang JY, Jeon YK, et al. microRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res 2011;17:4761-71
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4761-4771
    • Paik, J.H.1    Jang, J.Y.2    Jeon, Y.K.3
  • 38
    • 84857122981 scopus 로고    scopus 로고
    • The proto-oncogene Pim-1 is a target of miR-33a
    • Thomas M, Lange-Grunweller K, Weirauch U, et al. The proto-oncogene Pim-1 is a target of miR-33a. Oncogene 2012;31:918-28
    • (2012) Oncogene , Issue.31 , pp. 918-928
    • Thomas, M.1    Lange-Grunweller, K.2    Weirauch, U.3
  • 39
    • 84859560897 scopus 로고    scopus 로고
    • MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL
    • Baraniskin A, Birkenkamp-Demtroder K, Maghnouj A, et al. miR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. Carcinogenesis 2012;33:732-9
    • (2012) Carcinogenesis , Issue.33 , pp. 732-739
    • Baraniskin, A.1    Birkenkamp-Demtroder, K.2    Maghnouj, A.3
  • 40
    • 84858294570 scopus 로고    scopus 로고
    • MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer
    • publish online 23 Oct doi:10.1002/ijc.26485 2011
    • Song Y, Xu Y, Wang Z, et al. microRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer. Int J Cancer 2012;publish online 23 Oct 2011; doi:10.1002/ijc.26485
    • (2012) Int. J. Cancer
    • Song, Y.1    Xu, Y.2    Wang, Z.3
  • 41
    • 84863230238 scopus 로고    scopus 로고
    • Microrna-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1
    • Wu J, Wu G, Lv L, et al. microRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis 2012;33:519-28
    • (2012) Carcinogenesis , Issue.33 , pp. 519-528
    • Wu, J.1    Wu, G.2    Lv, L.3
  • 42
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C, Kelnar K, Liu B, et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011;17:211-15
    • (2011) Nat. Med. , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3
  • 43
    • 81555235150 scopus 로고    scopus 로고
    • MicroRNA 34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells
    • Lee YM, Lee JY, Ho CC, et al. microRNA 34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells. Breast Cancer Res 2011;13:R116
    • (2011) Breast Cancer Res. , vol.13
    • Lee, Y.M.1    Lee, J.Y.2    Ho, C.C.3
  • 44
    • 79959702659 scopus 로고    scopus 로고
    • Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro
    • Wu G, Yu F, Xiao Z, et al. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. Br J Cancer 2011;105:146-53
    • (2011) Br. J. Cancer , vol.105 , pp. 146-153
    • Wu, G.1    Yu, F.2    Xiao, Z.3
  • 45
    • 84863040849 scopus 로고    scopus 로고
    • Microrna-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1
    • Zhang W, Kong G, Zhang J, et al. microRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7:e31450
    • (2012) Plos One , Issue.7
    • Zhang, W.1    Kong, G.2    Zhang, J.3
  • 46
    • 84862831034 scopus 로고    scopus 로고
    • Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells
    • e9
    • Almeida MI, Nicoloso MS, Zeng L, et al. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology 2012;142:886-96.e9
    • (2012) Gastroenterology , Issue.142 , pp. 886-896
    • Almeida, M.I.1    Nicoloso, M.S.2    Zeng, L.3
  • 47
    • 84862806941 scopus 로고    scopus 로고
    • Microrna let-7a suppresses breast cancer cell migration and invasion through down-regulation of C-C chemokine receptor type 7
    • Kim SJ, Shin JY, Lee KD, et al. microRNA let-7a suppresses breast cancer cell migration and invasion through down-regulation of C-C chemokine receptor type 7. Breast Cancer Res 2012;14:R14
    • (2012) Breast Cancer Res. , Issue.14
    • Kim, S.J.1    Shin, J.Y.2    Lee, K.D.3
  • 48
    • 79959624589 scopus 로고    scopus 로고
    • MiR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-met
    • Wu ZS, Wu Q, Wang CQ, et al. miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met. Cancer 2011;117:2842-52
    • (2011) Cancer , vol.117 , pp. 2842-2852
    • Wu, Z.S.1    Wu, Q.2    Wang, C.Q.3
  • 49
    • 81855183857 scopus 로고    scopus 로고
    • Microrna-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
    • Srivastava SK, Bhardwaj A, Singh S, et al. microRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis 2011;32:1832-9
    • (2011) Carcinogenesis , vol.32 , pp. 1832-1839
    • Srivastava, S.K.1    Bhardwaj, A.2    Singh, S.3
  • 50
    • 79953649060 scopus 로고    scopus 로고
    • MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines
    • Viticchie G, Lena AM, Latina A, et al. miR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle 2011;10:1121-31
    • (2011) Cell Cycle , vol.10 , pp. 1121-1131
    • Viticchie, G.1    Lena, A.M.2    Latina, A.3
  • 51
    • 80051697939 scopus 로고    scopus 로고
    • Regulatory role of miR-203 in prostate cancer progression and metastasis
    • Saini S, Majid S, Yamamura S, et al. Regulatory role of miR-203 in prostate cancer progression and metastasis. Clin Cancer Res 2011;17:5287-98
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5287-5298
    • Saini, S.1    Majid, S.2    Yamamura, S.3
  • 52
    • 79952721604 scopus 로고    scopus 로고
    • Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion
    • Wei JJ, Wu X, Peng Y, et al. Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. Clin Cancer Res 2011;17:1297-305
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1297-1305
    • Wei, J.J.1    Wu, X.2    Peng, Y.3
  • 53
    • 84855685246 scopus 로고    scopus 로고
    • Mir-365 regulates lung cancer and developmental gene thyroid transcription factor 1
    • Qi J, Rice SJ, Salzberg AC, et al. miR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. Cell Cycle 2012;11:177-86
    • (2012) Cell Cycle , Issue.11 , pp. 177-186
    • Qi, J.1    Rice, S.J.2    Salzberg, A.C.3
  • 54
    • 84862907856 scopus 로고    scopus 로고
    • Polycomb-mediated loss of miR-31 activates NIK-dependent NFW kappaB pathway in adult T cell leukemia and other cancers
    • Yamagishi M, Nakano K, Miyake A, et al. Polycomb-mediated loss of miR-31 activates NIK-dependent NFW kappaB pathway in adult T cell leukemia and other cancers. Cancer Cell 2012;21:121-35
    • (2012) Cancer Cell , Issue.21 , pp. 121-135
    • Yamagishi, M.1    Nakano, K.2    Miyake, A.3
  • 55
    • 79960261778 scopus 로고    scopus 로고
    • EVI1-mediated down regulation of miR449a is essential for the survival of EVI1 positive leukaemic cells
    • De Weer A, Van Der Meulen J, Rondou P, et al. EVI1-mediated down regulation of miR449a is essential for the survival of EVI1 positive leukaemic cells. Br J Haematol 2011;154:337-48
    • (2011) Br. J. Haematol. , vol.154 , pp. 337-348
    • De Weer, A.1    Van Der Meulen, J.2    Rondou, P.3
  • 56
    • 84855176124 scopus 로고    scopus 로고
    • E-cadherin/ beta-catenin complex and the epithelial barrier
    • Tian X, Liu Z, Niu B, et al. E-cadherin/ beta-catenin complex and the epithelial barrier. J Biomed Biotechnol 2011;2011:567305
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 567305
    • Tian, X.1    Liu, Z.2    Niu, B.3
  • 57
    • 84855360862 scopus 로고    scopus 로고
    • MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer
    • Hirata H, Hinoda Y, Ueno K, et al. microRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer. Carcinogenesis 2012;33:41-8
    • (2012) Carcinogenesis , Issue.33 , pp. 41-48
    • Hirata, H.1    Hinoda, Y.2    Ueno, K.3
  • 58
    • 84857979406 scopus 로고    scopus 로고
    • MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer
    • Hirata H, Hinoda Y, Ueno K, et al. microRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer. Carcinogenesis 2012;33:501-8
    • (2012) Carcinogenesis , Issue.33 , pp. 501-508
    • Hirata, H.1    Hinoda, Y.2    Ueno, K.3
  • 59
    • 84155168994 scopus 로고    scopus 로고
    • Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1
    • Chung TK, Lau TS, Cheung TH, et al. Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. Int J Cancer 2012;130:1036-45
    • (2012) Int. J. Cancer , Issue.130 , pp. 1036-1045
    • Chung, T.K.1    Lau, T.S.2    Cheung, T.H.3
  • 60
    • 79551514024 scopus 로고    scopus 로고
    • MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase
    • Zhang L, Sullivan PS, Goodman JC, et al. microRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase. Cancer Res 2011;71:645-54
    • (2011) Cancer Res. , vol.71 , pp. 645-654
    • Zhang, L.1    Sullivan, P.S.2    Goodman, J.C.3
  • 61
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. microRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ. Epigenetics and genetics. microRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 2011;11:849-64
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 62
    • 84859568206 scopus 로고    scopus 로고
    • Exploiting the therapeutic potential of microRNAs in human cancer
    • Cho WC. Exploiting the therapeutic potential of microRNAs in human cancer. Expert Opin Ther Targets 2012;16:345-50
    • (2012) Expert Opin. Ther. Targets , Issue.16 , pp. 345-350
    • Cho, W.C.1
  • 63
    • 79956313718 scopus 로고    scopus 로고
    • Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer
    • Gong C, Yao Y, Wang Y, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem 2011;286:19127-37
    • (2011) J. Biol. Chem. , vol.286 , pp. 19127-37
    • Gong, C.1    Yao, Y.2    Wang, Y.3
  • 64
    • 84856231030 scopus 로고    scopus 로고
    • Mirna-34a is associated with docetaxel resistance in human breast cancer cells
    • Kastl L, Brown I, Schofield AC. miRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer Res Treat 2012;131:445-54
    • (2012) Breast Cancer Res. Treat , Issue.131 , pp. 445-454
    • Kastl, L.1    Brown, I.2    Schofield, A.C.3
  • 65
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tang SN, Rodova M, et al. Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One 2011;6:e24099
    • (2011) Plos One , vol.6
    • Nalls, D.1    Tang, S.N.2    Rodova, M.3
  • 66
    • 80052632447 scopus 로고    scopus 로고
    • MiR-34a targeting of Notch ligand delta-like 1 impairs CD15 +/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    • De Antonellis P, Medaglia C, Cusanelli E, et al. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15 +/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS One 2011;6:e24584
    • (2011) Plos One , vol.6
    • De Antonellis, P.1    Medaglia, C.2    Cusanelli, E.3
  • 67
    • 79957910157 scopus 로고    scopus 로고
    • MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy
    • Hikichi M, Kidokoro M, Haraguchi T, et al. microRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. Mol Ther 2011;19:1107-15
    • (2011) Mol. Ther. , vol.19 , pp. 1107-1115
    • Hikichi, M.1    Kidokoro, M.2    Haraguchi, T.3
  • 68
    • 79960963683 scopus 로고    scopus 로고
    • Microrna replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
    • Ibrahim AF, Weirauch U, Thomas M, et al. microRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 2011;71:5214-24
    • (2011) Cancer Res. , vol.71 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3
  • 69
    • 80054700249 scopus 로고    scopus 로고
    • Development of microRNA-145 for therapeutic application in breast cancer
    • Kim SJ, Oh JS, Shin JY, et al. Development of microRNA-145 for therapeutic application in breast cancer. J Control Release 2011;155:427-34
    • (2011) J. Control Release , vol.155 , pp. 427-434
    • Kim, S.J.1    Oh, J.S.2    Shin, J.Y.3
  • 70
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI
    • Yang YP, Chien Y, Chiou GY, et al. Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 2012;33:1462-76
    • (2012) Biomaterials , Issue.33 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3
  • 71
    • 84860350934 scopus 로고    scopus 로고
    • MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-kappaB-inducing kinase (NIK)
    • publish online 21 Nov 2011 doi:10.1038/onc.2011.523
    • Zhang S, Shan C, Kong G, et al. microRNA-520e suppresses growth of hepatoma cells by targeting the NF-kappaB-inducing kinase (NIK).Oncogene 2012;publish online 21 Nov 2011; doi:10.1038/onc.2011.523
    • (2012) Oncogene
    • Zhang, S.1    Shan, C.2    Kong, G.3
  • 72
    • 84863804699 scopus 로고    scopus 로고
    • Microrna-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo
    • publish online 7 Nov 2011 doi:10.1038/onc.2011.500
    • He XX, Chang Y, Meng FY, et al. microRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 2012;publish online 7 Nov 2011; doi:10.1038/onc.2011.500
    • (2012) Oncogene
    • He, X.X.1    Chang, Y.2    Meng, F.Y.3
  • 74
    • 84872219713 scopus 로고    scopus 로고
    • Epigenomics
    • Schwab M editor. 3rd edition. Springer; Heidelberg: 2012. In press
    • Cho WC. Epigenomics. In: SCHWAB M, editor. Encyclopedia of cancer. 3rd edition. Springer; Heidelberg: 2012. In press
    • Encyclopedia of Cancer
    • Cho, W.C.1
  • 75
    • 84855870562 scopus 로고    scopus 로고
    • Targeting the signaling pathways in cancer therapy
    • Cho WC. Targeting the signaling pathways in cancer therapy. Expert Opin Ther Targets 2012;16:1-3
    • (2012) Expert Opin. Ther. Targets , Issue.16 , pp. 1-3
    • Cho, W.C.1
  • 76
    • 79951979718 scopus 로고    scopus 로고
    • Micro RNAs: Master regulators as potential therapeutics in cancer
    • Garofalo M, Croce CM. microRNAs: Master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol 2011;51:25-43
    • (2011) Annu. Rev. Pharmacol. Toxicol. , vol.51 , pp. 25-43
    • Garofalo, M.1    Croce, C.M.2
  • 77
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: Rationale, strategies and challenges
    • Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat Rev Drug Discov 2010;9:775-89
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 78
    • 84863921084 scopus 로고    scopus 로고
    • Grand challenges and opportunities in deciphering the role of non-coding RNAs in human diseases
    • Cho WC. Grand challenges and opportunities in deciphering the role of non-coding RNAs in human diseases. Front Genet 2011;2:1
    • (2011) Front Genet. , vol.2 , pp. 1
    • Cho, W.C.1
  • 79
    • 77958449792 scopus 로고    scopus 로고
    • MicroRNAs in cancer: From bench to bedside
    • Cortez MA, Ivan C, Zhou P, et al. microRNAs in cancer: From bench to bedside. Adv Cancer Res 2010;108:113-57
    • (2010) Adv. Cancer Res. , vol.108 , pp. 113-157
    • Cortez, M.A.1    Ivan, C.2    Zhou, P.3


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