MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-B-inducing kinase (NIK)

Oncogene

Volumn 31, Issue 31, 2012, Pages 3607-3620

  Zhang, S ^a   Shan, C ^a   Kong, G ^a   Du, Y ^a   Ye, L ^a   Zhang, X ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

cell proliferation; DNA methylation; hepatocellular carcinoma; microRNA 520e; NF kB inducing kinase

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 520E; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE NIK; SYNAPTOTAGMIN I; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADULT; AGED; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INJECTIONS, INTRALESIONAL; LIVER NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MICRORNAS; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES;

MUS MUSCULUS;

EID: 84860350934     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.523     Document Type: Article

References (45)

1. Bartel DP. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
2. Bartel DP, Chen CZ. (2004). Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5: 396-400.
3. Brown KD, Claudio E, Siebenlist U. (2008). The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res Ther 10: 212.
4. Calin GA, Croce CM. (2006). MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866.
5. Calin GA, Croce CM. (2007). Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest 117: 2059-2066.
6. Chen CZ, Li L, Lodish HF, Bartel DP. (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86.
7. Chen KH, Weng MS, Lin JK. (2007). Tangeretin suppresses IL-1betainduced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochem Pharmacol 73: 215-227.
8. Croce CM, Calin GA. (2005). miRNAs, cancer, and stem cell division. Cell 122: 6-7.
9. Cui W, Zhang Y, Hu N, Shan C, Zhang S, Zhang W et al (2010). miRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 30UTR of CD46. Cancer Biol Ther 10: 232-241.
10. Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S et al (2008). Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68: 5049-5058.
11. Dhawan P, Richmond A. (2002). A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. J Biol Chem 277: 7920-7928.
12. El-Serag HB, Rudolph KL. (2007). Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
13. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E et al (2007). MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104: 15805-15810.
14. Farazi PA, DePinho RA. (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687.
15. Fazi F, Racanicchi S, Zardo G, Starnes LM, Mancini M, Travaglini L et al (2007). Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 12: 457-466.
16. Foehr ED, Bohuslav J, Chen LF, DeNoronha C, Geleziunas R, Lin X et al (2000). The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem275: 34021-34024.
17. Gessi M, Zur Muehlen A, Lauriola L, Gardiman MP, Giangaspero F, Pietsch T. (2011). TP53, beta-Catenin and c-myc/N-myc status in embryonal tumours with ependymoblastic rosettes. Neuropathol Appl Neurobiol 37: 406-413.
18. Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG et al (2007). Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 67: 6092-6099.
19. Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, Croce CM et al (2008). MicroRNA involvement in hepatocellular carcinoma. J Cell Mol Med 12: 2189-2204.
20. Gregory RI, Shiekhattar R. (2005). MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512.
21. Hayden MS, Ghosh S. (2008). Shared principles in NF-kappaB signaling. Cell 132: 344-362.
22. Ji J, Wang XW. (2009). New kids on the block: diagnostic and prognostic microRNAs in hepatocellular carcinoma. Cancer Biol Ther 8: 1686-1693.
23. Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ et al (2008). Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 14: 419-427.
24. Kent OA, Mendell JT. (2006). A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 25: 6188-6196.
25. Kim VN. (2005). MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 6: 376-385.
26. Kim VN, Nam JW. (2006). Genomics of microRNA. Trends Genet 22: 165-173.
27. Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C et al (2009a). Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16: 533-546.
28. Li Q, Wang G, Shan JL, Yang ZX, Wang HZ, Feng J et al (2010). MicroRNA-224 is upregulated in HepG2 cells and involved in cellular migration and invasion. J Gastroenterol Hepatol 25: 164-171.
29. Li S, Fu H, Wang Y, Tie Y, Xing R, Zhu J et al (2009b). MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. Hepatology 49: 1194-1202.
30. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J et al (2010). MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology 52: 1731-1740.
31. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al (2005). MicroRNA expression profiles classify human cancers. Nature 435: 834-838.
32. Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F et al (2007). Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 67: 1424-1429.
33. Lyle R, Watanabe D, te Vruchte D, Lerchner W, Smrzka OW,Wutz A et al (2000). The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1. Nat Genet 25: 19-21.
34. Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M et al (2008). The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS One 3: e4029.
35. Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J. (2009). NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. Biochem Biophys Res Commun 388: 96-101.
36. Nojima M, Suzuki H, Toyota M, Watanabe Y,Maruyama R, Sasaki S et al (2007). Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 26: 4699-4713.
37. Rangaswami H, Bulbule A, Kundu GC. (2004). Nuclear factorinducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. J Biol Chem 279: 38921-38935.
38. Roux PP, Blenis J. (2004). ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344.
39. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA et al (2006). Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443.
40. Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S et al (2007). Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis 28: 2459-2466.
41. Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y et al (2009). MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology 49: 1595-1601.
42. Shan C, Xu F, Zhang S, You J, You X, Qiu L et al (2010). Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res 20: 563-575.
43. Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. (2009). MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 50: 113-121.
44. Yamaguchi N, Ito T, Azuma S, Ito E, Honma R, Yanagisawa Y et al (2009). Constitutive activation of nuclear factor-kappaB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines. Cancer Sci 100: 1668-1674.
45. Ying SY, Lin SL. (2005). Intronic microRNAs. Biochem Biophys Res Commun 326: 515-520.