MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia

Oncogene

Volumn 31, Issue 1, 2012, Pages 80-92

  Zheng, Y S ^a,b   Zhang, H ^a   Zhang, X J ^a   Feng, D D ^a   Luo, X Q ^a   Zeng, C W ^a   Lin, K Y ^a   Zhou, H ^a   Qu, L H ^a   Zhang, P ^c   Chen, Y Q ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HAINAN UNIVERSITY   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

acute myeloblastic leukemia; granulocyte monocyte differentiation; microRNA; RBSP3 pRB E2F1 pathway

Indexed keywords

MICRORNA; MIR 100; PROTEIN RBSP3; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; E2F1 TRANSCRIPTION FACTOR; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MICRORNAS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

EID: 84855349331     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.208     Document Type: Article

References (48)

1. Anedchenko EA, Dmitriev AA, Krasnov GS. (2008). Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer. Mol Biol (Mosk) 42: 965-976.
2. Bartek J, Bartkova J, Lukas J. (1996). The retinoblastoma protein pathway and the restriction point. Curr Opin Cell Biol 8: 805-814. (Pubitemid 26399940)
3. Bartek J, Bartkova J, Lukas J. (1997). The retinoblastoma protein pathway in cell cycle control and cancer. Exp Cell Res 237: 1-6. (Pubitemid 27528021)
4. Bartel DP. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
5. Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, Starza RL, Bastard C et al. (2008). Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 205: 2499-2506.
6. Careccia S, Mainardi S, Pelosi A, Gurtner A, Diverio D, Riccioni R et al. (2009). Restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. Oncogene 28: 4034-4040.
7. Chen CZ. (2005). MicroRNAs as oncogenes and tumor suppressors. New Engl J Med 353: 1768-1771.
8. Chen PL, Scully P, Shew JY, Wang JY, Lee WH. (1989). Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58: 1193-1198. (Pubitemid 19238195)
9. Collins SJ, Robertson KA, Mueller L. (1990). Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). Mol Cell Biol 10: 2154-2163.
10. Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, Chaplin T et al. (2008). Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukemia. PLoS One 3: e2141.
11. Esquela-Kerscher A, Slack FJ. (2006). Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
12. Estey E, Dohner H. (2006). Acute myeloid leukemia. Lancet 368: 1894-1907.
13. Estey E. (2007). Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol 25: 1908-1915. (Pubitemid 46854425)
14. Farag SS, Ruppert AS, Mrozek K, Mayer RJ, Stone RM, Carroll AJ et al. (2005). Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyo-type: a Cancer and Leukemia Group B study. J Clin Oncol 23: 482-493. (Pubitemid 46224225)
15. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C et al. (2005). A mini-circuitry comprising microRNA-223 and transcription factors NFI-A and C/EBPa regulates human granulo-poiesis. Cell 123: 819-831. (Pubitemid 41721029)
16. Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F et al. (2007). MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 9: 775-787. (Pubitemid 47019464)
17. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T et al. (2009). MicroRNA 29b functions in acute myeloid leukemia. Blood 114: 5331-5341.
18. Ghosh A, Ghosh S, Maiti GP, Sabbir MG, Zabarovsky ER, Roy A et al. (2010). Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance. Cancer Sci 101: 1511-1520.
19. Guo XB, Guo L, Ji J, Zhang JN, Zhang J, Chen XH et al. (2010). MiRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer. Biochem Biophys Res Commun 398: 1-6.
20. Hall M, Peters G. (1996). Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68: 67-108. (Pubitemid 26099813)
21. Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M et al. (2004). SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 6: 731-740. (Pubitemid 39144478)
22. Han YC, Park CY, Bhagat G, Zhang J, Wang Y, Fan J et al. (2010). MicroRNA-29a induces aberrant self-renewal capacity in hemato-poietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med 207: 475-489.
23. Ji Y, Studzinski GP. (2004). Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvita-min D3-induced monocytic differentiation of HL60 cells. Cancer Res 64: 370-377. (Pubitemid 38114120)
24. Jiang JM, Lee EJ, Gusev Y, Schmittgen TD. (2005). Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 33: 5394-5403. (Pubitemid 41548806)
25. Jongen-Lavrencic M, Sun SM, Dijkstra MK, Valk PJM, Lowenberg B. (2008). MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 111: 5078-5085.
26. Kashuba VI, Li J, Wang F, Senchenko VN, Protopopov A, Malyukova A et al. (2004). RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. Proc Natl Acad Sci USA 101: 4906-4911. (Pubitemid 38469176)
27. Kashuba VI, Pavlova TV, Grigorieva EV, Kutsenko A, Yenamandra SP, Li J et al. (2009). High mutability of the tumor suppressor genes RASSF1and RBSP3 (CTDSPL) in cancer. PLoS One 4: e5231.
28. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG et al. (2009). MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 28: 3360-3370.
29. Leite KR, Sousa-Canavez JM, Reis ST, Tomiyama AH, Camara-Lopes LH, Sanudo A et al. (2009). Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. Urol Oncol 29: 265-269.
30. Li Z, Lu J, Sun M, Mi S, Zhang H, Luo RT et al. (2008). Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 105: 15535-15540.
31. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773. (Pubitemid 40292988)
32. Lin RJ, Lin YC, Yu AL. (2010). miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol Carcinog 49: 719-727.
33. Liu S, Wu LC, Pang J, Santhanam R, Schwind S, Wu YZ et al. (2010). Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 17: 333-347.
34. Lowenberg B, Downing JR, Burnett A. (1999). Acute myeloid leukemia. N Engl J Med 341: 1051-1062. (Pubitemid 29451802)
35. Nagaraja AK, Creighton CJ, Yu Z, Zhu H, Gunaratne PH, Reid JG et al. (2010). A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol Endocrinol 24: 447-463.
36. Pigazzi M, Manara E, Baron E, Basso G. (2009). MiR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res 69: 2471-2478.
37. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Muller-Tidow C, Bohlander SK et al. (2010). Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 115: 1768-1778.
38. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M et al. (2007). The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci USA 104: 19849-19854.
39. Senchenko VN, Anedchenko EA, Kondratieva TT, Krasnov GS, Dmitriev AA, Zabarovska VI et al. (2010). Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. BMC Cancer 10: 75.
40. Sherr CJ. (1996). Cancer cell cycles. Science 274: 1672-1677.
41. Shi W, Alajez NM, Bastianutto C, Hui AB, Mocanu JD, Ito E et al. (2010). Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. Int J Cancer 126: 2036-2048.
42. Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK. (2008). Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late-onset breast carcinoma: clinical and prognostic significance. Cancer Sci 99: 1984-1991.
43. Strauss M, Lukas J, Bartek J. (1995). Unrestricted cell cycling and cancer. Nat Med 1: 1245-1246.
44. Strom DK, Cleveland JL, Chellappan S, Nip J, Hiebert SW. (1998). E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation. Cell Growth Differ 9: 59-69. (Pubitemid 28049528)
45. Varnholt H, Drebber U, Schulze F, Wedemeyer I, Schirmacher P, Dienes HP et al. (2008). MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47: 1223-1232. (Pubitemid 351547908)
46. Wang J, Zhao Y, Kauss MA, Spindel S, Lian H. (2009). Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. Eur J Cell Biol 88: 103-115.
47. Weinberg RA. (1995). The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
48. Zhang H, Luo XQ, Zhang P, Huang LB, Zheng YS, Wu J et al. (2009). MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One 4: e7826.