Investigating substrate promiscuity in cyclooxygenase-2 the role of Arg-120 and residues lining the hydrophobic groove

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24619-24630

  Vecchio, Alex J ^a   Orlando, Benjamin J ^a   Nandagiri, Ritwik ^a   Malkowski, Michael G ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACIDS; BROAD SPECTRUM; CYCLOOXYGENASE 2; CYCLOOXYGENASES; HIGH AFFINITY BINDING; HYDROPHOBIC INTERACTIONS; ISOFORMS; LINOLENIC ACIDS; MUTATIONAL ANALYSIS; PROTOPORPHYRINS; STRUCTURAL DETERMINATION; STRUCTURE-FUNCTION ANALYSIS;

ALIGNMENT; AMINO ACIDS; CARBON; CARBOXYLATION; CATALYSIS; ENZYME INHIBITION; FATTY ACIDS; HYDROPHOBICITY; OXYGENATION; OXYGENATORS;

SUBSTRATES;

ARGININE; CARBON; CYCLOOXYGENASE 2; ISOENZYME; LINOLENIC ACID; PROTOPORPHYRIN COBALT;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; HYDROPHOBICITY; OXYGENATION; PRIORITY JOURNAL; PROTEIN INTERACTION;

ALPHA-LINOLENIC ACID; ANIMALS; ARACHIDONIC ACID; ARGININE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

MURINAE;

EID: 84863794061     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.372243     Document Type: Article

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