-
1
-
-
12944335304
-
Drug target validation: Lethal infection blocked by inducible peptide
-
Tao, J.; Wendler, P.; Connelly, G.; Lim, A.; Zhang, J.; King, M.; Li, T.; Silverman, J.A.; Schimmel, P.R.; Tally, F.P. Drug target validation: Lethal infection blocked by inducible peptide. Proc. Natl. Acad. Sci. USA, 2000, 97, 783-786.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 783-786
-
-
Tao, J.1
Wendler, P.2
Connelly, G.3
Lim, A.4
Zhang, J.5
King, M.6
Li, T.7
Silverman, J.A.8
Schimmel, P.R.9
Tally, F.P.10
-
2
-
-
0033782994
-
Aminoacyl-tRNAs synthesis
-
Ibba, M.; Soll, D. Aminoacyl-tRNAs synthesis. Annu. Rev. Biochem., 2000, 69, 617-650.
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 617-650
-
-
Ibba, M.1
Soll, D.2
-
3
-
-
0003174053
-
-
2nd ed. ASM Press, Washington, D.C.
-
Cashel, M.; Gentry, D. R.; Hernandez, V. J.; Vinella, D. Escherichia coli and Salmonella: cellular and molecular microbiology, vol. 1, 2nd ed. ASM Press, Washington, D.C., 1996, 1458-1496.
-
(1996)
Escherichia Coli and Salmonella: Cellular and Molecular Microbiology
, vol.1
, pp. 1458-1496
-
-
Cashel, M.1
Gentry, D.R.2
Hernandez, V.J.3
Vinella, D.4
-
4
-
-
0029126262
-
Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci
-
Cassels, R.; Oliva, B.; Knowles, D. Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci. J. Bacteriol., 1995, 177, 5161-5165.
-
(1995)
J. Bacteriol.
, vol.177
, pp. 5161-5165
-
-
Cassels, R.1
Oliva, B.2
Knowles, D.3
-
5
-
-
0016797460
-
Stringent control of ribonucleic acid synthesis in Bacillus subtilis treated with granaticin
-
Ogilvie, A.; Wiebauer, K; Kersten, W. Stringent control of ribonucleic acid synthesis in Bacillus subtilis treated with granaticin. Biochem. J., 1975, 152, 517-522.
-
(1975)
Biochem. J.
, vol.152
, pp. 517-522
-
-
Ogilvie, A.1
Wiebauer, K.2
Kersten, W.3
-
6
-
-
0029086353
-
SB 205952, a novel semisynthetic monic acid analog with at least two modes of action
-
Wilson, J. M.; Oliva, B.; Cassels, R.; O'Hanlon, P. J.; Chopra, I. SB 205952, a novel semisynthetic monic acid analog with at least two modes of action. Antimicrob. Agents Chemother, 1995, 39, 1925-1933.
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 1925-1933
-
-
Wilson, J.M.1
Oliva, B.2
Cassels, R.3
O'Hanlon, P.J.4
Chopra, I.5
-
7
-
-
0025601562
-
Uncharged tRNA, protein synthesis, and the bacterial stringent response
-
Goldman, E.; Jakubowski, H. Uncharged tRNA, protein synthesis, and the bacterial stringent response. Mol. Microbiol. 1990, 4, 2035-2040.
-
(1990)
Mol. Microbiol.
, vol.4
, pp. 2035-2040
-
-
Goldman, E.1
Jakubowski, H.2
-
8
-
-
0025158208
-
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
-
Eriani, G.; Delarue, M.; Poch, O.; Gangloff, J.; Moras, D. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature, 1990, 347, 203-206.
-
(1990)
Nature
, vol.347
, pp. 203-206
-
-
Eriani, G.1
Delarue, M.2
Poch, O.3
Gangloff, J.4
Moras, D.5
-
9
-
-
28844499031
-
Prospects for Aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents
-
Hurdle, J.G.; O'Neill, A.J.; Chopra, I. Prospects for Aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. Antimicrob. Agents Chemother., 2005, 49, 4821-4833.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 4821-4833
-
-
Hurdle, J.G.1
O'Neill, A.J.2
Chopra, I.3
-
10
-
-
0035819917
-
Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use
-
Raczniak, G.; Ibba, M.; Soll, D. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology, 2001, 160, 181-189.
-
(2001)
Toxicology
, vol.160
, pp. 181-189
-
-
Raczniak, G.1
Ibba, M.2
Soll, D.3
-
11
-
-
80051995882
-
Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents
-
Gallant, P.; Finn, J.; Keith, D.; Wendler, P. Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents. Expert Opin. Ther. Targets, 2000, 4, 1-9.
-
(2000)
Expert Opin. Ther. Targets
, vol.4
, pp. 1-9
-
-
Gallant, P.1
Finn, J.2
Keith, D.3
Wendler, P.4
-
12
-
-
0034633290
-
A homogeneous method to mea-jacyl-tRNA synthetase aminoacylation activity using scintillation prox-y technology
-
Macarron, R.; Mensah, L.; Cid, C.; Carranza, C.; Benson, N.; Pope, A. J.; Diez, E. A homogeneous method to mea-jacyl-tRNA synthetase aminoacylation activity using scintillation prox-y technology. Anal. Biochem., 2000, 284, 183-190.
-
(2000)
Anal. Biochem.
, vol.284
, pp. 183-190
-
-
MacArron, R.1
Mensah, L.2
Cid, C.3
Carranza, C.4
Benson, N.5
Pope, A.J.6
Diez, E.7
-
14
-
-
33746807698
-
Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors
-
Kim, S. Y.; Lee, Y. S.; Kang, T.; Kim, S.; Lee, J. Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors. Bioorg. & Med. Chem. Lett., 2006, 16, 4898-4907
-
(2006)
Bioorg. & Med. Chem. Lett.
, vol.16
, pp. 4898-4907
-
-
Kim, S.Y.1
Lee, Y.S.2
Kang, T.3
Kim, S.4
Lee, J.5
-
15
-
-
0000612893
-
-
Jo, Y. J.; Lee, S. W.; Jo, M. K.; Lee, J.; Kang, M.-K.; Yoon, J. H.; Kim, S. J. Biochem. Mol. Biol., 1999, 32, 547.
-
(1999)
Biochem. Mol. Biol.
, vol.32
, pp. 547
-
-
Jo, Y.J.1
Lee, S.W.2
Jo, M.K.3
Lee, J.4
Kang, M.-K.5
Yoon, J.H.6
Kim, S.J.7
-
16
-
-
0034633290
-
A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology
-
Macarron, R.; Mensah, L.; Cid, C.; Carranza, C.; Benson, N.; Pope, A. J.; Diez, E. A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology. Anal. Biochem., 2000, 284, 183-190.
-
(2000)
Anal. Biochem.
, vol.284
, pp. 183-190
-
-
MacArron, R.1
Mensah, L.2
Cid, C.3
Carranza, C.4
Benson, N.5
Pope, A.J.6
Diez, E.7
-
17
-
-
0043237736
-
Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase
-
Crepin, T.; Schmitt, E.; Mechulam, Y.; Sampson, P. B.; Vaughan, M. D.; Honek, J. F.; Blanquet, S. Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase. J. Mol. Biol., 2003, 332, 59-72.
-
(2003)
J. Mol. Biol.
, vol.332
, pp. 59-72
-
-
Crepin, T.1
Schmitt, E.2
Mechulam, Y.3
Sampson, P.B.4
Vaughan, M.D.5
Honek, J.F.6
Blanquet, S.7
-
18
-
-
1642619403
-
Potent and Selective Inhibitors of Bacterial Methionyl tRNA Synthetase Derived from an Oxazolone-Dipeptide Scaffold
-
Tandon, M.; Coffen, D. L.; Gallant, P.; Keith, D.; Ashwell, M. A. Potent and Selective Inhibitors of Bacterial Methionyl tRNA Synthetase Derived from an Oxazolone-Dipeptide Scaffold. Bioorg. Med. Chem. Lett., 2004, 14, 1909-1911.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 1909-1911
-
-
Tandon, M.1
Coffen, D.L.2
Gallant, P.3
Keith, D.4
Ashwell, M.A.5
-
19
-
-
0344177555
-
Methionine analogues as inhibitors of methionyl-tRNA synthetase
-
Lee, J.; Kang, M.; Kyoung, C.; Moon, W.; Jo, Y.; Kwak, J.; Kim, S. Methionine analogues as inhibitors of methionyl-tRNA synthetase. Bioorg. Med. Chem. Lett., 1998, 8, 3511-3514.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3511-3514
-
-
Lee, J.1
Kang, M.2
Kyoung, C.3
Moon, W.4
Jo, Y.5
Kwak, J.6
Kim, S.7
-
20
-
-
0033577740
-
Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase
-
Lee, J.; Kang, S.; Kang, M.; Chun, M.; Jo, Y.; Kwak, J.; Kim, S. Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. Bioorg. Med. Chem. Lett., 1999, 9, 1365-1370.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 1365-1370
-
-
Lee, J.1
Kang, S.2
Kang, M.3
Chun, M.4
Jo, Y.5
Kwak, J.6
Kim, S.7
-
21
-
-
0037046549
-
Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
-
Jarvest, R.; Berge, J.; Berry, V.; Boyd, H.; Brown, M.; Elder, J.; Forrest, A.; Fosberry, A.; Gentry, D.; Hibbs, M.; Jaworski, D.; O' Hanlon, P.; Pope, A.; Rittenhouse, S.; Sheppard, R.; Slater-Radosti, C.; Worby, A. Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens. J. Med. Chem., 2002, 45, 1959-1962.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1959-1962
-
-
Jarvest, R.1
Berge, J.2
Berry, V.3
Boyd, H.4
Brown, M.5
Elder, J.6
Forrest, A.7
Fosberry, A.8
Gentry, D.9
Hibbs, M.10
Jaworski, D.11
Hanlon P, O.'.12
Pope, A.13
Rittenhouse, S.14
Sheppard, R.15
Slater-Radosti, C.16
Worby, A.17
-
22
-
-
0037533953
-
Discovery of a Potent and Selective Series of Pyrazole Bacterial Methionyl-tRNA Synthetase Inhibitors
-
Finn, J.; Mattia, K.; Morytko, M.; Ram, S.; Yang, Y.; Wu, X.; Mak, E.; Gallant, P.; Keith, D. Discovery of a Potent and Selective Series of Pyrazole Bacterial Methionyl-tRNA Synthetase Inhibitors. Bioorg. Med. Chem. Lett., 2003, 13, 2231-2234.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 2231-2234
-
-
Finn, J.1
Mattia, K.2
Morytko, M.3
Ram, S.4
Yang, Y.5
Wu, X.6
Mak, E.7
Gallant, P.8
Keith, D.9
-
23
-
-
0033610812
-
Characterization of Isoleucyl-tRNA Synthetase from Staphylococcus aureus
-
Pope, A. J.; Moore, K. J.; McVey, M.; Mensah, L.; Benson, N.; Osborne, N.; Broom, N.; Brown, M. J. B.; O'Hanlon, P. Characterization of Isoleucyl-tRNA Synthetase from Staphylococcus aureus. J. Biol. Chem., 1998, 48, 31691-31701.
-
(1998)
J. Biol. Chem.
, vol.48
, pp. 31691-31701
-
-
Pope, A.J.1
Moore, K.J.2
McVey, M.3
Mensah, L.4
Benson, N.5
Osborne, N.6
Broom, N.7
Brown, M.J.B.8
O'Hanlon, P.9
-
24
-
-
47349092284
-
Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening
-
Finn J, Stidham M, Hilgers M, Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening. Bioorg. Med. Chem. Lett., 2008, 18, 3932-3937.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 3932-3937
-
-
Finn, J.1
Stidham, M.2
Hilgers, M.3
-
25
-
-
5644236834
-
Pharmacophore modeling and three dimensional database searching for drug design using catalyst: Recent advances
-
Güner, O.; Clement, O.; Kurogi, Y. Pharmacophore modeling and three dimensional database searching for drug design using catalyst: recent advances. Curr. Med. Chem. 2004, 11, 2991-3005.
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 2991-3005
-
-
Güner, O.1
Clement, O.2
Kurogi, Y.3
-
26
-
-
0026656836
-
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties
-
Takahashi, H.; Osada, H.; Koshino, H.; Kudo, T.; Amano, S.; Shimizu, S.; Yoshihama, M.; Isono, K. Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties. J. Antibiot., 1992, 45, 1409-1413.
-
(1992)
J. Antibiot.
, vol.45
, pp. 1409-1413
-
-
Takahashi, H.1
Osada, H.2
Koshino, H.3
Kudo, T.4
Amano, S.5
Shimizu, S.6
Yoshihama, M.7
Isono, K.8
-
27
-
-
19044377321
-
Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A
-
Miyamoto, Y.; Machida, K.; Mizunuma, M.; Emoto, Y.; Sato, N.; Miyahara, K.; Usui, T.; Osada, H.; Takahashi, H.; Hirata, D.; Miyakawa, T. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. J. Biol. Chem., 2002, 277, 28810-28814.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28810-28814
-
-
Miyamoto, Y.1
MacHida, K.2
Mizunuma, M.3
Emoto, Y.4
Sato, N.5
Miyahara, K.6
Usui, T.7
Osada, H.8
Takahashi, H.9
Hirata, D.10
Miyakawa, T.11
-
28
-
-
0026764947
-
Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D
-
Koshino, H.; Takahashi, H.; Osada, H.; Isono, K. Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D. J. Antibiot., 1992, 45, 1420-1427.
-
(1992)
J. Antibiot.
, vol.45
, pp. 1420-1427
-
-
Koshino, H.1
Takahashi, H.2
Osada, H.3
Isono, K.4
-
29
-
-
0027979020
-
Absolute configuration of reveromycin A, an inhibitor of the signal transduction of epidermal growth factor
-
Ubukata, M.; Koshino, H.; Osada, H.; Isono, K. Absolute configuration of reveromycin A, an inhibitor of the signal transduction of epidermal growth factor. J. Chem. Soc. Chem. Commun., 1994, 1877-1878.
-
(1994)
J. Chem. Soc. Chem. Commun.
, pp. 1877-1878
-
-
Ubukata, M.1
Koshino, H.2
Osada, H.3
Isono, K.4
-
30
-
-
0036888577
-
Chemical modification of reveromycin A and its biological activities
-
Shimizu, T.; Usui, T.; Machida, K.; Furuya, K.; Osada, H.; Nakata, T. Chemical modification of reveromycin A and its biological activities. Bioorg. Med. Chem. Lett., 2002, 12, 3363-3366.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 3363-3366
-
-
Shimizu, T.1
Usui, T.2
MacHida, K.3
Furuya, K.4
Osada, H.5
Nakata, T.6
-
31
-
-
44849138879
-
Synthesis and biological activities of reveromycin A and spirofungin A derivatives
-
Shimizu, T.; Usui, T.; Fujikura, M.; Kawatani, M.; Satoh, T.; Machida, K.; Kanoh, N.; Woo, J. T.; Osada, H.; Sodeoka, M. Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg. Med. Chem. Lett., 2008, 18, 3756-3760.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 3756-3760
-
-
Shimizu, T.1
Usui, T.2
Fujikura, M.3
Kawatani, M.4
Satoh, T.5
MacHida, K.6
Kanoh, N.7
Woo, J.T.8
Osada, H.9
Sodeoka, M.10
-
32
-
-
0021978328
-
Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use
-
Sutherland, R.; Boon, R. J.; Griffin, K. E.; Masters, P. J.; Slocombe, B.; White, A. R. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob. Agents Chemother., 1985, 27, 495-498.
-
(1985)
Antimicrob. Agents Chemother.
, vol.27
, pp. 495-498
-
-
Sutherland, R.1
Boon, R.J.2
Griffin, K.E.3
Masters, P.J.4
Slocombe, B.5
White, A.R.6
-
33
-
-
0001212912
-
Uber antagonistenunterden bakterien Corresp.-Bl
-
Badder, A.; Garre, C. Uber antagonistenunterden bakterien, Corresp.-Bl. Sweiz.Aertze, 1887, 17, 385-392.
-
(1887)
Sweiz.Aertze
, vol.17
, pp. 385-392
-
-
Badder, A.1
Garre, C.2
-
34
-
-
0015230679
-
Pseudomonic acid: An antibiotic produced by Pseudomonas fluorescens
-
Fuller, A. T.; Mellows, G.; Woolford, M.; Banks, G. T.; Barrow, K. D.; Chain, E. B. Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature, 1971, 234, 416-417.
-
(1971)
Nature
, vol.234
, pp. 416-417
-
-
Fuller, A.T.1
Mellows, G.2
Woolford, M.3
Banks, G.T.4
Barrow, K.D.5
Chain, E.B.6
-
35
-
-
37049104142
-
The chemistry of pseudomonic acid. Part 1. The absolute configuration of pseudomonic acid A
-
Alexander, R. G.; Clayton, J. P.; Luk, K.; Rogers, N. H.; King, T. J. The chemistry of pseudomonic acid. Part 1. The absolute configuration of pseudomonic acid A. J. Chem. Soc., Perkin Trans. I, 1978, 561-567.
-
(1978)
J. Chem. Soc., Perkin Trans.
, vol.1
, pp. 561-567
-
-
Alexander, R.G.1
Clayton, J.P.2
Luk, K.3
Rogers, N.H.4
King, T.J.5
-
36
-
-
0017803523
-
On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureus
-
Hughes, J.; Mellows, G. On the mode of action of pseudomonic acid: inhibition of protein synthesis in Staphylococcus aureus. J. Antibiot., 1978, 31, 330-335.
-
(1978)
J. Antibiot.
, vol.31
, pp. 330-335
-
-
Hughes, J.1
Mellows, G.2
-
37
-
-
0019214230
-
How does pseudomonas fluorescens, the producing organism of the antibiotic pseudomonic acid A, avoid suicide?
-
Hughes, J.; Mellows, G.; Soughton, S. How does pseudomonas fluorescens, the producing organism of the antibiotic pseudomonic acid A, avoid suicide? FEBS Lett., 1980, 122, 322-334.
-
(1980)
FEBS Lett.
, vol.122
, pp. 322-334
-
-
Hughes, J.1
Mellows, G.2
Soughton, S.3
-
38
-
-
0033610812
-
Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics
-
Pope, A. J.; Moore, K. J.; McVey, M.; Mensah, L.; Benson, N.; Osbourne, N.; Broom, M. J. B.; O'Hanlon, P. Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics. J. Biol. Chem., 1998, 273, 31691-31701.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31691-31701
-
-
Pope, A.J.1
Moore, K.J.2
McVey, M.3
Mensah, L.4
Benson, N.5
Osbourne, N.6
Broom, M.J.B.7
O'Hanlon, P.8
-
39
-
-
0034705213
-
Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A
-
Brown, M. J. B.; Mensah, L. M.; Doyle, M. L.; Broom, N. J. P.; Osbourne, N.; Forrest, A. K.; Richardson, C. M.; O'Hanlon, P. J.; Pope, A. Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A. J. Biochemistry, 2000, 39, 6003-6011.
-
(2000)
J. Biochemistry
, vol.39
, pp. 6003-6011
-
-
Brown, M.J.B.1
Mensah, L.M.2
Doyle, M.L.3
Broom, N.J.P.4
Osbourne, N.5
Forrest, A.K.6
Richardson, C.M.7
O'Hanlon, P.J.8
Pope, A.9
-
40
-
-
0033551859
-
Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin
-
Silvian, L. F.; Wang, J.; Steitz, T. A. Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science, 1999, 285, 1074-1077.
-
(1999)
Science
, vol.285
, pp. 1074-1077
-
-
Silvian, L.F.1
Wang, J.2
Steitz, T.A.3
-
41
-
-
4243366671
-
The Pseudomonic Acids
-
Class, Y. J.; DeShong, P. The Pseudomonic Acids. Chem. Rev., 1995, 95, 1843-1857.
-
(1995)
Chem. Rev.
, vol.95
, pp. 1843-1857
-
-
Class, Y.J.1
Deshong, P.2
-
42
-
-
37049094347
-
The chemistry of pseudomonic acid. Part 3. The rearrangement of pseudomonic acid A in acid and basic solution
-
Clayton, J. P.; Oliver, R. S.; Rogers, N. P.; King, T. J. J. Chem. Soc. Perkin Trans. I, The chemistry of pseudomonic acid. Part 3. The rearrangement of pseudomonic acid A in acid and basic solution. 1979, 838-846.
-
(1979)
J. Chem. Soc. Perkin Trans. i
, pp. 838-846
-
-
Clayton, J.P.1
Oliver, R.S.2
Rogers, N.P.3
King, T.J.4
-
43
-
-
0027771318
-
Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium. Fermentation, isolation, structure, and antimicrobial activity
-
Shiozawa, H.; Kagasaki, T.; Kinoshita, T.; Haruyama, H.; Domon, H.; Utsui, Y.; Kodama, K.; Takahashi, S. Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium. Fermentation, isolation, structure, and antimicrobial activity. J. Antibiot., 1993, 46, 1834-1842.
-
(1993)
J. Antibiot.
, vol.46
, pp. 1834-1842
-
-
Shiozawa, H.1
Kagasaki, T.2
Kinoshita, T.3
Haruyama, H.4
Domon, H.5
Utsui, Y.6
Kodama, K.7
Takahashi, S.8
-
44
-
-
0028064891
-
Configurational studies on thiomarinol
-
Shiozawa, H.; Takahashi, S. Configurational studies on thiomarinol. J. Antibiot., 1994, 47, 851-853.
-
(1994)
J. Antibiot.
, vol.47
, pp. 851-853
-
-
Shiozawa, H.1
Takahashi, S.2
-
45
-
-
0029161961
-
Thiomarinols B and C, new antimicrobial antibiotics produced by a marine bacterium
-
Shiozawa, H.; Kagasaki, T.; Torikata, A.; Tanaka, N.; Fujimoto, K.; Hata, T.; Furukawa, Y.; Takahashi, S. Thiomarinols B and C, new antimicrobial antibiotics produced by a marine bacterium. J. Antibiot., 1995, 48, 907-909;
-
(1995)
J. Antibiot.
, vol.48
, pp. 907-909
-
-
Shiozawa, H.1
Kagasaki, T.2
Torikata, A.3
Tanaka, N.4
Fujimoto, K.5
Hata, T.6
Furukawa, Y.7
Takahashi, S.8
-
46
-
-
0030943101
-
Thiomarinols D, E, F and G, new hybrid antimicrobial antibiotics produced by a marine bacterium; Isolation, structure, and antimicrobial activity
-
Shiozawa, H.; Shimada, A.; Takahashi, S. Thiomarinols D, E, F and G, new hybrid antimicrobial antibiotics produced by a marine bacterium; isolation, structure, and antimicrobial activity. J. Antibiot., 1997, 50, 449-452.
-
(1997)
J. Antibiot.
, vol.50
, pp. 449-452
-
-
Shiozawa, H.1
Shimada, A.2
Takahashi, S.3
-
47
-
-
0027067947
-
Pseudomonic Acid-Derivatives from a Marine Bacterium
-
Stierle, D. B.; Stierle, A. A. Pseudomonic Acid-Derivatives from a Marine Bacterium. Experientia, 1992, 48, 1165-1169.
-
(1992)
Experientia
, vol.48
, pp. 1165-1169
-
-
Stierle, D.B.1
Stierle, A.A.2
-
48
-
-
1242293879
-
A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases
-
Yu, X. Y.; Finn, J.; Hill, J. M.; Wang, Z. G.; Keith, D.; Silverman, J.; Oliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg. Med. Chem. Lett., 2004, 14, 1339-1342.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 1339-1342
-
-
Yu, X.Y.1
Finn, J.2
Hill, J.M.3
Wang, Z.G.4
Keith, D.5
Silverman, J.6
Oliver, N.7
-
49
-
-
17144381316
-
Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase
-
Jarvest, R. L.; Erskine, S. G.; Forrest, A. K.; Fosberry, A. P.; Hibbs, M. J.; Jones, J. J.; O'Hanlon, P. J.; Sheppard, R. J.; Worby, A. Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. Bioorg. Med. Chem. Lett., 2005, 15, 2305-2309.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 2305-2309
-
-
Jarvest, R.L.1
Erskine, S.G.2
Forrest, A.K.3
Fosberry, A.P.4
Hibbs, M.J.5
Jones, J.J.6
O'Hanlon, P.J.7
Sheppard, R.J.8
Worby, A.9
-
50
-
-
58549117083
-
Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase
-
Montgomery, J. I.; Toogood, P. L.; Hutchings, K. M.; Liu, J.; Narasimhan, L.; Braden, T.; Dermyer, M. R.; Kulynych, A. D.; Smith, Y. D.; Warmus, J. S.; Taylor, C. Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase. Bioorg. Med. Chem. Lett., 2009, 19, 665-669.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 665-669
-
-
Montgomery, J.I.1
Toogood, P.L.2
Hutchings, K.M.3
Liu, J.4
Narasimhan, L.5
Braden, T.6
Dermyer, M.R.7
Kulynych, A.D.8
Smith, Y.D.9
Warmus, J.S.10
Taylor, C.11
-
51
-
-
1942453243
-
Ligand efficiency: A useful metric for lead selection
-
Hopkins, A. L.; Groom, C. R.; Alex, A. Ligand efficiency: a useful metric for lead selection. Drug Discovery Today, 2004, 9, 430-431.
-
(2004)
Drug Discovery Today
, vol.9
, pp. 430-431
-
-
Hopkins, A.L.1
Groom, C.R.2
Alex, A.3
-
52
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
Leeson, P. D.; Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat. Rev. Drug Disc., 2007, 6, 881-890.
-
(2007)
Nat. Rev. Drug Disc.
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
|