Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A

Biochemistry

Volumn 39, Issue 20, 2000, Pages 6003-6011

  Brown, Murray J B ^a   Mensah, Lucy M ^a   Doyle, Michael L ^a   Broom, Nigel J P ^a   Osbourne, Neal ^a   Forrest, Andrew K ^a   Richardson, Christine M ^a   O'Hanlon, Peter J ^a   Pope, Andrew J ^a  

^a SmithKline Beecham ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ISOLEUCINE TRANSFER RNA LIGASE; PSEUDOMONIC ACID; TRANSFER RNA;

AMINOACYLATION; ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; ENZYME INHIBITORS; ENZYME STABILITY; ISOLEUCINE; ISOLEUCINE-TRNA LIGASE; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUPIROCIN; SPECTROMETRY, FLUORESCENCE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0034705213     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000148v     Document Type: Article

References (33)

1. Silvian, L. F., Wang, J. M., and Steitz, T. A. (1999) Science 285, 1074-1077.
2. Meinnel, T., Mechulam, Y., and Blanquet, S. (1995) in tRNA, structure, biosynthesis and function (Soll, D., and RajBhandary, U. L., Eds.) pp 251-292, ASM Press, Washington DC.
3. Carter, C. W., Jr. (1993) Annu. Rev. Biochem. 62, 715-748.
4. von der Haar, F., Gabius, H.-J., and Cramer, F. (1981) Angew. Chem., Int. Ed. Engl. 20, 217-223.
5. Schimmel, P., Tao, J., and Hill, J. (1998) FASEB J. 12, 1599-1609.
6. Biryukov, A. I., Zhukov, Yu-N., Lavrik, O. I., and Khomutov, R. M. (1990) FEBS Lett. 273, 208-210.
7. Laske, R., Schonenberger, H., Holler, E. (1989) Arch. Pharm. 322, 847-852.
8. Nass, G., Poralla, K., and Zahner, H. (1969) Biochim. Biophys. Acta 34, 84-91.
9. Paetz, W., and Nass, G. (1973) Eur. J. Biochem. 35, 331-333.
10. Tanaka, K., Tamoki, M., and Watanabe, S. (1969) Biochim. Biophys. Acta 195, 244-245.
11. Ogilvie, A., Wiebauer, K., and Kersten, W. (1975) Biochem. J. 152, 511-515.
12. Werner, R. G., Thorpe, L. F., Reuter, W., and Nierhaus, K. H. (1976) Eur. J. Biochem. 68, 1-3.
13. Konrad, I., and Roschenthaler, R. (1977) FEBS Lett. 83, 341-347.
14. Konishi, M., Nishio, M., Saitoh, K., Miyaki, T., Oki, T., and Kawaguchi, H. (1989) I. Production, isolation, physicochemical properties and structure. J. Antibiot. (Tokyo) 42, 1749-1755.
15. Hughes, J., and Mellows, G. (1978) J. Antiobiot. 31, 330-335.
16. Hughes, J., and Mellows, G. (1980) Biochem. J. 191, 209-219.
17. Pope, A. J., Moore, K. J., McVey, M., Mensah, L., Benson, N., Osbourne, N., Broom, N., Brown, M. J. B., and O'Hanlon, P. (1998) J. Biol. Chem 273, 31691-31701.
18. Pope, A. J., Lapointe, J., Mensah, L., Brown, M. J. B., Benson, N., and Moore, K. J. (1998) J. Biol. Chem. 273, 31680-31690.
19. Pope, A. J., McVey, M., Fantom, K., and Moore K. J. (1998) J. Biol. Chem. 273, 31702-31706.
20. Chalker, A. F., Ward, J. M., Fosberry, A. P., and Hodgson, J. E. (1994) Gene 141, 103-108.
21. Fersht, A. R. (1984) Enzyme Structure and Mechanism, ISBN 7167-1614, Freeman & Company, New York.
22. Fuller, A. T., Mellows, G., Woodford, M., Banks, G. T., Barrow, K. D., and Chain, E. B. (1971) Nature 234, 416-417.
23. Leatherbarrow, R. (1992) Erithacus Software Ltd., London.
24. Barshop, B. A., Wrenn, R. F., and Freiden, C. (1983) Anal. Biochem. 130, 134-145.
25. Mendes, P. (1993) Comput. Appl. Biosci. 9, 563-571.
26. Mendes, P. (1997) Trends Biochem. Sci. 22, 361-363.
27. Brandts, J. F., and Lin, L.-N. (1990) Biochemistry 29, 6927-6940.
28. Weber, P. C., Pantoliano, M. W., Simons, D. M., Salemme, F. R. (1994) J. Am. Chem. Soc. 116, 2717-2724.
29. Doyle, M. L., and Hensley, P. (1998) Method Enzymol. 295, 88-99.
30. Privalov, P. L., and Khechinashvili, N. N. (1974) J. Mol. Biol. 86, 665-684.
31. Quanta available from Molecular Simulations Inc, 9685, Scranton Road, San Diego, CA, 92121-3752, http://www. msi.com.
32. Forrest, A. K., Pengelly, D., and O'Hanlon, P. J. WO 97/05126.
33. Nureki, O., Vassylyev, D. G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Hendrickson, T., Schimmel, P., Yokoyama, S. (1998) Science 280, 578-582.